Protein Alignment SIAH2 and sina

DIOPT Version :10

• Sequence 1: NP_005058.3
• Gene: SIAH2 / 6478
• HGNCID: 10858
• Length: 324
• Species: Homo sapiens
• Sequence 2: NP_476725.1
• Gene: sina / 39884
• FlyBaseID: FBgn0003410
• Length: 314
• Species: Drosophila melanogaster
• Alignment Length: 305
• Identity: 221/305 - (72%)
• Similarity: 246/305 - (80%)
• Gaps: 15/305 - (4%)

Human    27 PSPAAPPAAAT-----------ISAAGPGSSAVPAAAAVISGPGGGGGAGPVSPQHHELTSLFEC 80
            |:.||..|.||           .|:||..|||..::::..|....|||...:|.   :|||||||
  Fly    12 PTAAAAGAGATGVATNTSTSTGSSSAGNTSSANTSSSSSSSLSSAGGGDAGMSA---DLTSLFEC 73

Human    81 PVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTPSIRNLAMEKVASAVLFPCKYATTGC 145
            ||||||||||||||.:|||||..||.||:|||||||.|. :|||||||||||.|.||||::..||
  Fly    74 PVCFDYVLPPILQCSSGHLVCVSCRSKLTCCPTCRGPLA-NIRNLAMEKVASNVKFPCKHSGYGC 137

Human   146 SLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVMSHLMHAHKSITTLQGEDIVFLATDI 210
            :.:|.:|||.|||:.||.|||.||||||||||||.|:.||.|||.:|||||||||||||||||||
  Fly   138 TASLVYTEKTEHEETCECRPYLCPCPGASCKWQGPLDLVMQHLMMSHKSITTLQGEDIVFLATDI 202

Human   211 NLPGAVDWVMMQSCFGHHFMLVLEKQEKYEGHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLT 275
            |||||||||||||||||||||||||||||:|||||||||.|||:||:||||.|||||||||||||
  Fly   203 NLPGAVDWVMMQSCFGHHFMLVLEKQEKYDGHQQFFAIVQLIGSRKEAENFVYRLELNGNRRRLT 267

Human   276 WEATPRSIHDGVAAAIMNSDCLVFDTAIAHLFADNGNLGINVTIS 320
            |||.|||||:|||:||.|||||||||:||.|||||||||||||||
  Fly   268 WEAMPRSIHEGVASAIHNSDCLVFDTSIAQLFADNGNLGINVTIS 312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIAH2	NP_005058.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..42		7/25 (28%)
		RING-HC_SIAH2	75..125	CDD:438410	39/49 (80%)
		Sina	122..318	CDD:460824	162/195 (83%)
		SBD. /evidence=ECO:0000250|UniProtKB:P61092	130..322		158/191 (83%)
sina	NP_476725.1	RING_Ubox	68..118	CDD:473075	40/50 (80%)
		Sina	114..310	CDD:460824	162/195 (83%)