Protein Alignment SIAH1 and sina

DIOPT Version :10

• Sequence 1: NP_001006611.1
• Gene: SIAH1 / 6477
• HGNCID: 10857
• Length: 313
• Species: Homo sapiens
• Sequence 2: NP_476725.1
• Gene: sina / 39884
• FlyBaseID: FBgn0003410
• Length: 314
• Species: Drosophila melanogaster
• Alignment Length: 306
• Identity: 219/306 - (71%)
• Similarity: 241/306 - (78%)
• Gaps: 21/306 - (6%)

Human    28 KRKEMSRQTATALPTGTSKCPPSQRVPALTGTTASNN---------------------DLASLFE 71
            ||:|.:...|.|..||.:....:....:..|.|:|.|                     ||.||||
  Fly     8 KRREPTAAAAGAGATGVATNTSTSTGSSSAGNTSSANTSSSSSSSLSSAGGGDAGMSADLTSLFE 72

Human    72 CPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGC 136
            |||||||||||||||.||||||.:||.||||||||||||.:||||||||||::|.||||::..||
  Fly    73 CPVCFDYVLPPILQCSSGHLVCVSCRSKLTCCPTCRGPLANIRNLAMEKVASNVKFPCKHSGYGC 137

Human   137 EITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDI 201
            ..:|.:|||.:|||.||.|||.||||||||||||.||.||.|||..|||||||||||||||||||
  Fly   138 TASLVYTEKTEHEETCECRPYLCPCPGASCKWQGPLDLVMQHLMMSHKSITTLQGEDIVFLATDI 202

Human   202 NLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLT 266
            ||||||||||||||||.||||||||||||||||||||||||||:||:||||.|||||||:|||||
  Fly   203 NLPGAVDWVMMQSCFGHHFMLVLEKQEKYDGHQQFFAIVQLIGSRKEAENFVYRLELNGNRRRLT 267

Human   267 WEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISM 312
            |||.|||||||:|:||.||||||||||||||||:|||||||||||:
  Fly   268 WEAMPRSIHEGVASAIHNSDCLVFDTSIAQLFADNGNLGINVTISL 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIAH1	NP_001006611.1	RING-HC_SIAH2	67..117	CDD:438410	42/49 (86%)
		Sina	113..309	CDD:460824	163/195 (84%)
sina	NP_476725.1	RING_Ubox	68..118	CDD:473075	42/49 (86%)
		Sina	114..310	CDD:460824	163/195 (84%)