Protein Alignment SIAH1 and CG32486

DIOPT Version :10

• Sequence 1: NP_001006611.1
• Gene: SIAH1 / 6477
• HGNCID: 10857
• Length: 313
• Species: Homo sapiens
• Sequence 2: NP_647765.1
• Gene: CG32486 / 38367
• FlyBaseID: FBgn0266918
• Length: 412
• Species: Drosophila melanogaster
• Alignment Length: 326
• Identity: 71/326 - (21%)
• Similarity: 113/326 - (34%)
• Gaps: 130/326 - (39%)

Human    40 LPTGTSKCPPSQRVPALTG-----TTASNNDLAS-------LFE-----------CPVCFDYVLP 81
            |.|..|..||::: ..|.|     |::|.:.|.|       :.|           |.||.|....
  Fly    59 LDTQGSGEPPAKK-QLLDGGGGGATSSSGSSLLSSAAAASGMHEKLAHRISNALCCAVCLDLPKT 122

Human    82 PILQCQSGHLVCSNC----------RPKLTCCPTCRGPLG---SIRNLAMEKVANSVLFPCKYAS 133
            .:.|||.|||:|:.|          |.::..||.||..:.   :.||||:||.|:.:...|::
  Fly   123 AMYQCQMGHLMCAACFTHLLADGRLRDQIATCPNCRVEISKSTASRNLAVEKAASELPSECQF-- 185

Human   134 SGCEITLPHTEKADHEE-LCEFRPYSCPCPGASCKWQGSLDAVMPH---LMHQHKSITTLQGEDI 194
              |....|:.....||: .|:.||..|......|:|:|.......|   .:|..||
  Fly   186 --CNKEFPYKSLERHEQHECQERPTKCKYHRIGCQWRGPYHETNEHERNCLHPQKS--------- 239

Human   195 VFLATDINLPGAVDWVMMQSCFGFHFMLVLE------KQEKYDGHQQFFAIVQLIGTRK------ 247
                                  |:..|..||      |:||    :.|..::.|:...|
  Fly   240 ----------------------GYEVMAALEAHDDRIKEEK----KMFNTLIDLLSYEKIIFNDL 278

Human   248 -----QAENFAYRL------------------ELN--------GHRRRLTWE-------ATPRSI 274
                 :.:.:.::|                  .:|        .:.|.:|::       :||.||
  Fly   279 QMKPYRTDEYVHKLFYETARFSAFNQQWVVKARINNSQRDPHQSNERTITYQLILKTKTSTPMSI 343

Human   275 H 275
            |
  Fly   344 H 344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIAH1	NP_001006611.1	RING-HC_SIAH2	67..117	CDD:438410	21/80 (26%)
		Sina	113..309	CDD:460824	42/217 (19%)
CG32486	NP_647765.1	RING-HC_CYHR1	102..163	CDD:438168	17/60 (28%)
		Sina	168..>230	CDD:460824	19/65 (29%)
		CYHR1_C	251..412	CDD:439370	15/98 (15%)