Protein Alignment CREB3L2 and Atf6

DIOPT Version :10

• Sequence 1: NP_919047.2
• Gene: CREB3L2 / 64764
• HGNCID: 23720
• Length: 520
• Species: Homo sapiens
• Sequence 2: NP_995745.1
• Gene: Atf6 / 35480
• FlyBaseID: FBgn0033010
• Length: 741
• Species: Drosophila melanogaster
• Alignment Length: 650
• Identity: 131/650 - (20%)
• Similarity: 211/650 - (32%)
• Gaps: 240/650 - (36%)

Human    37 SELLDEFSQNVLG-QLLNDPFLSEKSVSMEVEPSPTSPAPLIQAEHSYSLCEEPRAQS-PFTHIT 99
            |||:.:..:...| ...::|..||.|:|     ||.|           .|.:.|.|.| .|....
  Fly    46 SELIPDLQKEAFGLHFSSNPITSEFSLS-----SPIS-----------GLKQIPSACSGEFKRNV 94

Human   100 TSDSFNDDEVESEKWYLSTDFPSTSIKTEPVTDEPPPGLVPSVTLTITAIS-------------- 150
            ..::|..|...|.                  .|.|.|...|:.:|..:.::
  Fly    95 NDNNFQLDLTNSR------------------NDLPEPNSSPTRSLNRSNVNGCSNEEAVYPLLVD 141

Human   151 --------TPLEKEEPPLEMNTGVDSSCQTIIPKIKLEPHEVDQFLNFSPKEAPVDHLHLPPTPP 207
                    .|.:...|..|.|:.:.:     :..||.|..|..|.|.|:....
  Fly   142 SDKFDPFFEPAKVRSPNKEFNSTISN-----LSDIKNELPETSQDLGFNSYNT------------ 189

Human   208 SSHGSDSEGSLSPNPRLH-PFSLPQTHSPSRAAPRAPSALSSSPLLTAPHKLQGSGPL------- 264
            |.:.|....|...|..|: ...:|:|..|.......||......|.|.  |..|...|
  Fly   190 SRNNSTLTKSWPINTELNLDNQVPKTVLPLSRTIYLPSHDYKGLLPTV--KCNGDRTLKKNVNVR 252

Human   265 -----VLTEEEKRTLIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEY------ 318
                 ::.:::..|.|..   :....|....::|..||.:|.|||:.||..||:|:|||
  Fly   253 SKISNIVIKKKNATFIQS---LKESTPSHTMDDKIYKKYQRMIKNRESASLSRKKRKEYVVSLET 314

Human   319 -MDSLEKKVESCSTENLELRKKVEVL------------------------ENTNRTLLQQLQKLQ 358
             ::.|||:.:|...||:.||.::.:|                        ||.|.....:
  Fly   315 RINKLEKECDSLKAENITLRDQIFLLATSCQRESGNANGLLHNYSGSERSENKNGRFTSK----- 374

Human   359 TLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAF-----GSFFQGYGPYPS-----------ATKM 407
                   ::.|....| |.|....|.:.||:||     ...||.|...|:           ..::
  Fly   375 -------AKHCNKNNT-TATIKKNVAILFAMAFVVSLNAGNFQKYLNIPNNLEGKSEIEPVGKQL 431

Human   408 ALPSQHSL----------------------QEP---YTASVVRSRNLLIYEE-----------HS 436
            ::.::..|                      :||   :..|.:|:..:..:|.           :.
  Fly   432 SMSNRRLLWADSEEEYKEKNNLSTFLSGKQKEPSLYFLNSGIRNHKINSFENITKNVSHTYSYNE 496

Human   437 PPEES------------SSPGSAGE---------LGGWDRGSSLLRVSG---------------- 464
            ||..:            |..||:.:         |..|..|:  |.||.
  Fly   497 PPPLTYLSTRNCINRCRSHNGSSNQSKYFMLAQNLHKWISGT--LNVSNFSKEKEDSNGFEFFNN 559

Human   465 -LESRPDVDLPH-----FIISNETSLEKSVLLELQQHLVSAKLEGN--ETLKVV-ELDRRVNTTF 520
             .|.:.|:.:.|     ||..|:.:   |||.|.||.|.:.|...|  |.:.|: :::||.:|.:
  Fly   560 YFEEKRDIHIKHEKRKMFIDLNDYT---SVLPEKQQKLNNTKSFENMREQINVISKIERRDDTFY 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CREB3L2	NP_919047.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	195..264		14/69 (20%)
		Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	296..325		16/35 (46%)
		bZIP_CREB3	305..348	CDD:269837	19/73 (26%)
		coiled coil	305..348	CDD:269837	19/73 (26%)
		Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	336..357		6/44 (14%)
		S1P recognition. /evidence=ECO:0000303|PubMed:17178827	427..430		0/2 (0%)
Atf6	NP_995745.1	bZIP_ATF6	287..338	CDD:269848	21/50 (42%)
		coiled coil	287..338	CDD:269848	21/50 (42%)