Protein Alignment CREB3L2 and CrebB

DIOPT Version :10

• Sequence 1: NP_919047.2
• Gene: CREB3L2 / 64764
• HGNCID: 23720
• Length: 520
• Species: Homo sapiens
• Sequence 2: NP_001334685.1
• Gene: CrebB / 32817
• FlyBaseID: FBgn0265784
• Length: 331
• Species: Drosophila melanogaster
• Alignment Length: 265
• Identity: 63/265 - (23%)
• Similarity: 103/265 - (38%)
• Gaps: 68/265 - (25%)

Human   125 IKTEPVTDEPPPGLVPSVTLT-----ITAISTPLEK----EEPPLEMNTGVDSSCQTIIPKIKLE 180
            ::.:.|....|.|::.:...|     ..|.:|.::|    .:||   |:.|          |...
  Fly    99 LQVQSVIQANPSGVIQTAAGTQQQQQALAAATAMQKVVYVAKPP---NSTV----------IHTT 150

Human   181 PHEVDQFLNFSPKEAPVDHLHLPPTPPSSHGSDSEGSLSPNPRLHPFSLPQTHSPS--------- 236
            |....|..|..|...|   ..:.|.|.:.|..||:.|||.:...|..| ..|..||
  Fly   151 PGNAVQVRNKIPPTFP---CKIKPEPNTQHPEDSDESLSDDDSQHHRS-ELTRRPSYNKIFTEIS 211

Human   237 ------RAAPRAPSALSSSPLLTAPHKLQGSGPLVLTEEEKRTLIAEGYPIPTKLPLSK-----S 290
                  .:.|.:...|:|        :|.|:|............:...|.:..::..:.     :
  Fly   212 GPDMSGASLPMSDGVLNS--------QLAGTGAGGNAANSSLMQLDPTYYLSNRMSYNTNNSGIA 268

Human   291 EEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRKKVEVLENTNRTLLQQLQ 355
            |::..|:..|..||:.:|:|.|||||||:..||              .:|.||||.|:.|:::|:
  Fly   269 EDQTRKREIRLQKNREAARECRRKKKEYIKCLE--------------NRVAVLENQNKALIEELK 319

Human   356 KLQTL 360
            .|:.|
  Fly   320 SLKEL 324

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CREB3L2	NP_919047.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	195..264		20/83 (24%)
		Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	296..325		15/28 (54%)
		bZIP_CREB3	305..348	CDD:269837	16/42 (38%)
		coiled coil	305..348	CDD:269837	16/42 (38%)
		Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	336..357		8/20 (40%)
		S1P recognition. /evidence=ECO:0000303|PubMed:17178827	427..430
CrebB	NP_001334685.1	pKID	<191..>214	CDD:396650	5/23 (22%)
		bZIP_CREB1	274..327	CDD:269838	25/65 (38%)
		coiled coil	275..327	CDD:269838	24/64 (38%)