DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMURF2 and Y92H12A.2

DIOPT Version :9

Sequence 1:	NP_073576.1	Gene:	SMURF2 / 64750	HGNCID:	16809	Length:	748	Species:	Homo sapiens
Sequence 2:	NP_001293292.1	Gene:	Y92H12A.2 / 171719	WormBaseID:	WBGene00022358	Length:	724	Species:	Caenorhabditis elegans

Alignment Length:	816	Identity:	290/816 - (35%)
Similarity:	406/816 - (49%)	Gaps:	186/816 - (22%)

- Green bases have known domain annotations that are detailed below.

Human     4 PGGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTV--------KNTLDPK 60
            |....|....||:.:|....|.|:|...:..|:..:.::.|    :.|||        |.|.:|.
Worm    11 PPNTDNETELLRVRLLRGTKLGKRDLLGVCSPYCMIRLENS----NGDTVDEVQVETKKKTRNPT 71

Human    61 WNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDN 125
            ||..:...:.::..:.|.|::..::.|....||:.  |.|::.:            :....||..
Worm    72 WNSVFTFRVTRACQMKILVYDENRLRKDVLMGFVS--RTLNDGL------------ITTQAPNPE 122

Human   126 DTVRGQIVVSLQSRDRIGTGGQVVDCSRLF----------DND--------------LPDGWEER 166
            :       .:|||    ||..:......||          ||.              :|.|||||
Worm   123 E-------YALQS----GTASKGKSIGSLFLSFHFMPSSSDNSPSDSTADLQQTSSGMPQGWEER 176

Human   167 RTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGATCGQSSDPRLAER 231
            ...:||..|:||..||||:                       ..|.|.:||.....:....:.|.
Worm   177 EDGNGRTVYVNHALRTTQF-----------------------TPPESVSNGNVDAITEQSVIEET 218

Human   232 RVRSQRHRNYMSRTHLHTPPD-----------------------------------LPEGYEQRT 261
            |   :|..||..|:.:...|.                                   ||:|::.:.
Worm   219 R---RRRDNYEHRSQVTDEPSDTTIVSNELTAIDDAMRANFERGGGHVEEEEDELRLPDGWDMQV 280

Human   262 TQQGQVYFLHTQTGVSTWHDP------RVPRDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNN 320
            ...|:.:|:..:|..:||.||      |||. |.....:|:|.||.|||.|..|.|||:|:|||.
Worm   281 APNGRTFFIDHRTKTTTWTDPRPGAATRVPL-LRGKTDDEIGALPAGWEQRVHADGRVFFIDHNR 344

Human   321 RTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVSLCPDDTECLTVPR--YKRDLVQKLKILRQEL 383
            |.||:.|||.                            :.|.:..|.  |.||..:|::.||..|
Worm   345 RRTQWEDPRF----------------------------ENENIAGPAVPYSRDYKRKVEYLRSRL 381

Human   384 SQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHE 448
            .:....:|.|.:.|.|:.:||:|||.:|..:..||..:|.|:|.||.|||||||.|||.:||||:
Worm   382 PKPNSNSGKCDMVVHRDTLFEDSYRHIMDKKDYDLRNKLWIEFFGETGLDYGGVTREWFFLLSHQ 446

Human   449 MLNPYYGLFQYSRDDIYTLQINPDS-AVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQL 512
            :.|||||||:||..|.|||||||.| |.||||||||||:|||:|||::||..:|..|..||||.:
Worm   447 IFNPYYGLFEYSATDNYTLQINPHSEACNPEHLSYFHFIGRIIGMAIYHGKLLDAFFIRPFYKMM 511

Human   513 LGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVNEEN 577
            |||.|||.|||.||.:.:|||:::.:|| ...|:.||.::.:.:||....||.|||.::||.|:|
Worm   512 LGKKITLFDMESVDNEYYNSLIYVKDND-PADLELTFSLDDSIFGETQNIELIPNGANVPVTEDN 575

Human   578 KKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTR 642
            |:||            |||           |:|.:||:.||..||||::|||.||||.|||.||.
Worm   576 KEEY------------IEA-----------VVPSNLLRLFDANELELLMCGLQKIDVKDWKANTI 617

Human   643 LK-HCTPDSNIVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDAC 706
            .| ...|.|.:|..|||.:..||.|.|||:||||:|:||||:.||:.|.|:.|.:.|||.:..:
Worm   618 YKGGYGPSSQVVHNFWKCILSFDNEMRARVLQFVSGTSRVPMNGFRELYGSNGLQKFTIERWGS- 681

Human   707 TNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEET 742
            .:.||:|||||||:|:|||.::::|..|||||||.:
Worm   682 ADMLPRAHTCFNRLDLPPYTTFKELKSKLLTAIENS 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMURF2	NP_073576.1	C2_Smurf-like	13..137	CDD:176028	25/131 (19%)
SMURF2	NP_073576.1	HUL4	<159..745	CDD:227354	254/629 (40%)
Y92H12A.2	NP_001293292.1	C2	20..147	CDD:301316	32/155 (21%)
		WW	170..198	CDD:278809	15/50 (30%)
		WW	272..301	CDD:278809	8/28 (29%)
		WW	323..353	CDD:197736	18/29 (62%)
		HECTc	393..721	CDD:238033	181/350 (52%)
		HECTc	415..720	CDD:214523	173/328 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100256
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2273
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740