DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SHOX2 and ey

DIOPT Version :9

Sequence 1:	NP_003021.3	Gene:	SHOX2 / 6474	HGNCID:	10854	Length:	355	Species:	Homo sapiens
Sequence 2:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster

Alignment Length:	440	Identity:	93/440 - (21%)
Similarity:	135/440 - (30%)	Gaps:	238/440 - (54%)

- Green bases have known domain annotations that are detailed below.

Human    80 GGGAGGGAGGGRSPVRELDMGAAERSREPGSPRLTEGRRKPTKAEVQATLLLPGEAFRFLVSPEL 144
            |.|.|..:.||.|     ::|..|                    :.||.|:|
  Fly   441 GSGEGENSNGGAS-----NIGNTE--------------------DDQARLIL------------- 467

Human   145 KDRKEDAKGMEDEGQTKIKQRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQ 209
                            |.|.:|:||:||.:|::.||:.|:.|||||.|.||.|:.::||.|||:|
  Fly   468 ----------------KRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQ 516

Human   210 VWFQNRRAKCRKQE-------------------------------NQLH--KGVLIGAAS----- 236
            |||.|||||.|::|                               |.|.  ..:|.|:|.
  Fly   517 VWFSNRRAKWRREEKLRNQRRTPNSTGASATSSSTSATASLTDSPNSLSACSSLLSGSAGGPSVS 581

Human   237 ------------------------------------------------QFEACR----------- 242
                                                            |.|.||
  Fly   582 TINGLSSPSTLSTNVNAPTLGAGIDSSESPTPIPHIRPSCTSDNDNGRQSEDCRRVCSPCPLGVG 646

Human   243 ----------------------VAPYVNVG--------------ALRMPFQQDSHCNVTPL-SFQ 270
                                  ::|.:|..              ||.|   .||:..|||: ||.
  Fly   647 GHQNTHHIQSNGHAQGHALVPAISPRLNFNSGSFGAMYSNMHHTALSM---SDSYGAVTPIPSFN 708

Human   271 --------------VQAQLQLDS-----------AVAHAHHHLHP-----------------HLA 293
                          .|..|...|           .:|.||||:.|                 :|.
  Fly   709 HSAVGPLAPPSPIPQQGDLTPSSLYPCHMTLRPPPMAPAHHHIVPGDGGRPAGVGLGSGQSANLG 773

Human   294 AH---APYMMFPAPPFGLPLATLAADSASAASVVAAAAAAKTTSKNSSIA 340
            |.   :.|.:..|  :.||...:|:.||:.:|..||::|:...:.:.:||
  Fly   774 ASCSGSGYEVLSA--YALPPPPMASSSAADSSFSAASSASANVTPHHTIA 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SHOX2	NP_003021.3	Homeobox	167..220	CDD:306543	31/52 (60%)
SHOX2	NP_003021.3	OAR	335..351	CDD:309087	2/6 (33%)
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	31/51 (61%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940