Protein Alignment SHOX and CG34367

DIOPT Version :10

• Sequence 1: NP_000442.1
• Gene: SHOX / 6473
• HGNCID: 10853
• Length: 292
• Species: Homo sapiens
• Sequence 2: NP_001097140.1
• Gene: CG34367 / 5740879
• FlyBaseID: FBgn0085396
• Length: 420
• Species: Drosophila melanogaster
• Alignment Length: 424
• Identity: 151/424 - (35%)
• Similarity: 193/424 - (45%)
• Gaps: 142/424 - (33%)

Human     1 MEELTAFVSKSFDQKSKDG------NGGGGGGGGK----KDSI---------TYREVLESGLARS 46
            ||:|..||:|||:....:.      |...|....|    |:||         :|.:...|| ..|
  Fly     1 MEQLAQFVTKSFEFNLTNNSVHALFNSMTGARLKKPTEVKNSIFINSISSGGSYADTCASG-EES 64

Human    47 RELGTSDSSLQDI---------------TEGGGHCPVH------------------LFKDHVDND 78
            .::..:|.|:.:.               ::...|...:                  |..:.:|.|
  Fly    65 VDIDITDLSVSESNTILAIDPEPTEESHSQREEHVETYSLSPTLHKAAVEPKPKNWLISEDLDVD 129

Human    79 KE----KLKEFGTARVAEGIYECKE--------------KREDVKSEDEDGQ-------TKL--- 115
            .:    |:....||    .|.||.|              ..|.|..|....:       |.|
  Fly   130 SQPEDPKMSGLPTA----SITECTEDSNTPKLAPDKPLLPEECVSPEPSRNREHCDPLDTSLVNT 190

Human   116 KQRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQENQMH 180
            |||||||||||:|||||||||:|||||||||||||||||||||||||||||||||||||.|||||
  Fly   191 KQRRSRTNFTLDQLNELERLFEETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKHENQMH 255

Human   181 KGVILGT-----ANHLDACRVAPYVNMGALRM------PFQQVQAQLQLEGVAHA---------- 224
            ||.::|:     |..|:.|||||||::.|||.      |.....:..|..||:..
  Fly   256 KGFLVGSRSPPIATPLEPCRVAPYVSLAALRSSSVPSHPAAATSSNPQAPGVSGTSSSGKVVTVD 320

Human   225 HPHLH-------------PHLAAHAPYLMFPPPPFGLPIASLAESASAAAV-------------- 262
            .||.|             ..:||.|.:..|.|     .|.|:|....|||:
  Fly   321 SPHNHNPAISRSAIKQFSSTVAAAAAFSAFDP-----AIISVAAHQYAAAITNGTVPAGLFSVPQ 380

Human   263 ----VAAAAKSNSKNSSIADLRLKARKHAEALGL 292
                :||.|.::||:|||||||:||:||:|:|||
  Fly   381 YSINLAAFAAAHSKSSSIADLRMKAKKHSESLGL 414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SHOX	NP_000442.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34		14/51 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	100..119		7/28 (25%)
		Homeodomain	118..174	CDD:459649	53/55 (96%)
		SH3-binding. /evidence=ECO:0000255	242..249		1/6 (17%)
		OAR	272..288	CDD:461067	12/15 (80%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	274..287		10/12 (83%)
CG34367	NP_001097140.1	Homeodomain	193..249	CDD:459649	53/55 (96%)
		OAR	392..410	CDD:461067	13/17 (76%)