Protein Alignment SHOX and CG11294

DIOPT Version :10

• Sequence 1: NP_000442.1
• Gene: SHOX / 6473
• HGNCID: 10853
• Length: 292
• Species: Homo sapiens
• Sequence 2: NP_572500.1
• Gene: CG11294 / 31807
• FlyBaseID: FBgn0030058
• Length: 261
• Species: Drosophila melanogaster
• Alignment Length: 182
• Identity: 63/182 - (34%)
• Similarity: 83/182 - (45%)
• Gaps: 45/182 - (24%)

Human   116 KQRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQEN--- 177
            :|||:||.||.:||.|||.||.:|||||.|:|||::.|:.||||||||||||||||.|||..
  Fly    23 RQRRNRTTFTPQQLQELEALFQKTHYPDVFLREEVALRISLSEARVQVWFQNRRAKWRKQARLQL 87

Human   178 ----------------QMHKGVILG-------------TANHL-------DACRVAPYVNMGALR 206
                            .|..|.:.|             |..:|       :...|....|.|:..
  Fly    88 LQDAWRMRCLSLGTPPVMGGGAVQGGSGNGATARPPSQTPENLSSASKDSELAEVGNGPNSGSFT 152

Human   207 M---PFQQVQAQLQLEGVAHAHPHLHPHLA-AHAPYLMFPPPPFGLPIASLA 254
            |   .|||...|.|.:|  |........|: .:....::..|..|:.:..:|
  Fly   153 MMHPAFQQQHQQQQHQG--HQQATDQDKLSKTYTELKLYKAPSHGMELGGMA 202

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SHOX	NP_000442.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	100..119		1/2 (50%)
		Homeodomain	118..174	CDD:459649	39/55 (71%)
		SH3-binding. /evidence=ECO:0000255	242..249		2/6 (33%)
		OAR	272..288	CDD:461067
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	274..287
CG11294	NP_572500.1	Homeodomain	29..81	CDD:459649	36/51 (71%)