DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SHH and Shh

DIOPT Version :9

Sequence 1:	NP_000184.1	Gene:	SHH / 6469	HGNCID:	10848	Length:	462	Species:	Homo sapiens
Sequence 2:	NP_033196.1	Gene:	Shh / 20423	MGIID:	98297	Length:	437	Species:	Mus musculus

Alignment Length:	462	Identity:	405/462 - (87%)
Similarity:	413/462 - (89%)	Gaps:	26/462 - (5%)

- Green bases have known domain annotations that are detailed below.

Human     1 MLLLARCLLLVLVSSLLVCSGLACGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGASGRYEGK 65
            :||||||.|::|.||||||.|||||||||||||||||||||||||||||||||||||||||||||
Mouse     2 LLLLARCFLVILASSLLVCPGLACGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGASGRYEGK 66

Human    66 ISRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEGWDE 130
            |:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    67 ITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEGWDE 131

Human   131 DGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAENSVAAKS 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   132 DGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAENSVAAKS 196

Human   196 GGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDQGRLLYSDFLTFLDRDDGAKKVFYVIETREP 260
            |||||||||||||||||||||||.||||||||||||||||||||||||||:|||||||||||.||
Mouse   197 GGCFPGSATVHLEQGGTKLVKDLRPGDRVLAADDQGRLLYSDFLTFLDRDEGAKKVFYVIETLEP 261

Human   261 RERLLLTAAHLLFVAPHNDSATGEPEASSGSGPPSGGALGPRALFASRVRPGQRVYVVAERDGDR 325
            |||||||||||||||||||           |||..    ||.|||||||||||||||||||.|||
Mouse   262 RERLLLTAAHLLFVAPHND-----------SGPTP----GPSALFASRVRPGQRVYVVAERGGDR 311

Human   326 RLLPAAVHSVTLSEEAAGAYAPLTAQGTILINRVLASCYAVIEEHSWAHRAFAPFRLAHALLAAL 390
            ||||||||||||.||.|||||||||.|||||||||||||||||||||||||||||||||||||||
Mouse   312 RLLPAAVHSVTLREEEAGAYAPLTAHGTILINRVLASCYAVIEEHSWAHRAFAPFRLAHALLAAL 376

Human   391 APARTDRGGDSGGGDRGGGGGRVALTAPGAADAPGAGATAGIHWYSQLLYQIGTWLLDSEALHPL 455
            ||||||          |||||.:. .|..|.:|.||..||||||||||||.|||||||||.:|||
Mouse   377 APARTD----------GGGGGSIP-AAQSATEARGAEPTAGIHWYSQLLYHIGTWLLDSETMHPL 430

Human   456 GMAVKSS 462
            |||||||
Mouse   431 GMAVKSS 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SHH	NP_000184.1	Cardin-Weintraub. /evidence=ECO:0000269\|PubMed:23118222	32..38		5/5 (100%)
		HH_signal	39..184	CDD:279432	143/144 (99%)
		Hint	187..448	CDD:279426	212/260 (82%)
		Hint	198..363	CDD:238035	139/164 (85%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	279..302		5/22 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	395..414		7/18 (39%)
Shh	NP_033196.1	Cardin-Weintraub. /evidence=ECO:0000269\|PubMed:23118222	33..39		5/5 (100%)
		HH_signal	40..185	CDD:279432	143/144 (99%)
		Hint	188..423	CDD:279426	212/260 (82%)
		Hint	199..349	CDD:238035	139/164 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83960782
Domainoid	1	1.000	398	1.000	Domainoid score	I11394
eggNOG	1	0.900	-	-		E1_KOG3638
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H30961
Inparanoid	1	1.050	795	1.000	Inparanoid score	I7993
Isobase	1	0.950	-	0.704428	Normalized mean entropy	S4101
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG50028
OrthoDB	1	1.010	-	-		D1169356at2759
OrthoFinder	1	1.000	-	-		FOG0001612
OrthoInspector	1	1.000	-	-		oto118647
orthoMCL	1	0.900	-	-		OOG6_104977
Panther	1	1.100	-	-	LDO	PTHR11889
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6290
SonicParanoid	1	1.000	-	-		X1177
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	19	19.250