DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SHH and wrt-4

DIOPT Version :9

Sequence 1:	NP_000184.1	Gene:	SHH / 6469	HGNCID:	10848	Length:	462	Species:	Homo sapiens
Sequence 2:	NP_510593.1	Gene:	wrt-4 / 181664	WormBaseID:	WBGene00006950	Length:	557	Species:	Caenorhabditis elegans

Alignment Length:	211	Identity:	58/211 - (27%)
Similarity:	95/211 - (45%)	Gaps:	41/211 - (19%)

- Green bases have known domain annotations that are detailed below.

Human   188 ENSVAAKSGG---------------CFPGSATVHLEQGGTKLVKDLSPGDRVLAADDQG-RLLYS 236
            :|.|.|...|               ||||.|.|::..||.|.:.:|:.||.|.|.|..| ::.:.
Worm   321 QNPVPAAPAGYAPMGFAPSGLQLYYCFPGDAMVNVYNGGFKRMDELAVGDWVQALDKNGSQVTFI 385

Human   237 DFLTFLDRDDGAKKVFYVIE-TREPRERLLLTAAHLLFV----APHNDSATGEPEASSGSGPPSG 296
            ....:|.||  .|:|...:| |.:..|...||..||:||    .|::     |.|..:.:..|
Worm   386 PVQYWLHRD--PKQVADFVEFTLDNGETFSLTEKHLVFVTQCSVPYS-----EDENINANPVP-- 441

Human   297 GALGPRALFASRVRPGQRVYVVAERDGDRRLLPAAVHSVTLSEEAAGAYAPLTAQGTILINRVLA 361
                     |.||..|...| :|.|...:......|..:.:.:: .|.|:|:|::|.:|::|:.|
Worm   442 ---------AERVNIGDCFY-IAHRKKSQMYQRVKVLDINIVQK-TGIYSPMTSRGHLLVDRIHA 495

Human   362 SCYAVIEEHSWAHRAF 377
            ||::..:.:|..:..|
Worm   496 SCHSETDNYSLQNTFF 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SHH	NP_000184.1	Cardin-Weintraub. /evidence=ECO:0000269\|PubMed:23118222	32..38
		HH_signal	39..184	CDD:279432
		Hint	187..448	CDD:279426	58/211 (27%)
		Hint	198..363	CDD:238035	50/170 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	279..302		3/22 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	395..414
wrt-4	NP_510593.1	Hint	342..547	CDD:279426	54/190 (28%)
wrt-4	NP_510593.1	Hint	346..497	CDD:238035	50/170 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161448466
Domainoid	1	1.000	79	1.000	Domainoid score	I6066
eggNOG	1	0.900	-	-		E1_KOG3638
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.704428	Normalized mean entropy	S4101
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1169356at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm4948
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.700