DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SH2D7 and Sh2d7

DIOPT Version :9

Sequence 1:	XP_011520197.1	Gene:	SH2D7 / 646892	HGNCID:	34549	Length:	453	Species:	Homo sapiens
Sequence 2:	NP_776139.2	Gene:	Sh2d7 / 244885	MGIID:	2441692	Length:	458	Species:	Mus musculus

Alignment Length:	444	Identity:	289/444 - (65%)
Similarity:	332/444 - (74%)	Gaps:	11/444 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MEDSLKQLSLGRDPEGAGDSQALAELQELALKWFMETQAPFILQNGALPPWFHGFITRKQTEQLL 65
            ||...:||.||:..|.||..:||||:||||||||||||||.|||||.||||||||||||||||||
Mouse     1 MEGGPEQLHLGKALEEAGGGRALAEIQELALKWFMETQAPSILQNGVLPPWFHGFITRKQTEQLL 65

Human    66 RDKALGSFLIRLSDRATGYILSYRGSDRCRHFVINQLRNRRYIISGDTQSHSTLAELVHHYQEAQ 130
            ||||||||||||||||.|||||||||||||||||||||||||::||||.|||||.||:.||||.|
Mouse    66 RDKALGSFLIRLSDRAVGYILSYRGSDRCRHFVINQLRNRRYLVSGDTLSHSTLDELLRHYQEVQ 130

Human   131 LEPFKEMLTAACPRPEDNDLYDAITRGLHQTIVDPENPPATAFLTVVPDKAASPRSSPKPQVSFL 195
            ||||.|.|.|||||.|:|||||||..||..|.:..: .|||.|.:::||||.|||...|||||||
Mouse   131 LEPFGETLAAACPRLEENDLYDAINTGLQHTNLSLK-IPATEFPSMLPDKATSPRLPAKPQVSFL 194

Human   196 HAQKSLDVSPRNLSQEESMEAPIRVSPLPEKSSSLLEESFGGPSDIIYADLRRMNQARLGLGTEG 260
            | :|:||:|.|::|.|.|.|.|.||.|:|.:|.|||:||..||||:||.|||::|:|:||||||.
Mouse   195 H-KKALDMSSRSVSDEVSAEVPTRVPPIPRRSPSLLDESPAGPSDVIYTDLRKINRAQLGLGTEV 258

Human   261 SGRHGPVPAGSQAYSPGREAQRRLSDGEQNRPDGLGPVLSGVSPDQGPTESPTSWG-----CSDA 320
            .|...|..|||.|.|||||...:|||.:||:|:.|||..||:.||||.|...||.|     .|:.
Mouse   259 WGTLRPASAGSLACSPGREPSGKLSDEDQNKPNSLGPAPSGMKPDQGSTMPYTSLGFSLPPSSET 323

Human   321 MGSLGATWRQEFPKLSQEAQPCSQGSSADIYEFIGTEGLLQEARDTPDQEGSTYEQIPACWGGPA 385
            :||...||||.|.|||.|||..|:.||.|.|..:.|.||.|||||.|||.||.|||||.||.|.|
Mouse   324 LGSQATTWRQGFLKLSHEAQSSSEASSTDTYHLVETPGLQQEARDRPDQRGSPYEQIPTCWHGTA 388

Human   386 RAPHPGASPTYS----PWVHGYKRISGTPELSEPGNTYEQIPATKSKETGRTHK 435
            :..:||.|||||    |..:||::||||.:|.|||||||||||.|:|:|||.||
Mouse   389 KLSYPGVSPTYSQQSGPMDYGYEKISGTSKLPEPGNTYEQIPAAKNKDTGRVHK 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SH2D7	XP_011520197.1	SH2_SH2D7	43..144	CDD:199832	88/100 (88%)
Sh2d7	NP_776139.2	SH2_SH2D7	43..144	CDD:199832	88/100 (88%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..235		16/30 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..326		29/58 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83961023
Domainoid	1	1.000	376	1.000	Domainoid score	I12299
eggNOG	1	0.900	-	-		E1_28P84
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H18355
Inparanoid	1	1.050	584	1.000	Inparanoid score	I10842
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG34667
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0010824
OrthoInspector	1	1.000	-	-		oto115446
orthoMCL	1	0.900	-	-		OOG6_125724
Panther	1	1.100	-	-	LDO	PTHR14388
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7847
SonicParanoid	1	1.000	-	-		X8364
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.290