Protein Alignment SHBG and LpR2

DIOPT Version :9

• Sequence 1: NP_001031.2
• Gene: SHBG / 6462
• HGNCID: 10839
• Length: 402
• Species: Homo sapiens
• Sequence 2: NP_001097928.1
• Gene: LpR2 / 43105
• FlyBaseID: FBgn0051092
• Length: 1064
• Species: Drosophila melanogaster
• Alignment Length: 246
• Identity: 52/246 - (21%)
• Similarity: 79/246 - (32%)
• Gaps: 95/246 - (38%)

Human    25 RQGWALRPVLPTQSAHDPPAVHLSNGPGQEPIAVMTFDLTKITKTSSSFEVRTWDPEGVIFYGDT 89
            |.|......:.|||.:..|   :..|..:      |..|||.:.||....| .|....| ::.||
  Fly   648 RTGMIFWSDVATQSIYKAP---IDEGNDR------TVVLTKSSVTSDGLAV-DWIYNHV-YFTDT 701

Human    90 -------------------------------NPKDDWFMLGLRDGRPEIQLHNHWAQLTVGAGPR 123
                                           :|.:.|.               :|:..  ||.||
  Fly   702 HKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWM---------------YWSDW--GASPR 749

Human   124 LD----DGRWHQV-----EVKMEGDSVLLEVDGEEVLRLRQVSGPLT---------SKRHPIMRI 170
            ::    ||. |:.     :||.. :.:.|::..:   ||..|.|.|.         |:||.:
  Fly   750 IERAGMDGT-HRTAIITYDVKWP-NGITLDLVQK---RLYWVDGKLNTISSSNYDGSQRHQV--- 806

Human   171 ALGGLLFPASNLRLPL-VPALDGCLRRDSWLDKQAEISASAPTSLRSCDVE 220
                 |:....||.|. :...:..:....| ||||...|:   .....|||
  Fly   807 -----LYSGEYLRHPFSITTFEDYVYWTDW-DKQAVFKAN---KFNGMDVE 848

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SHBG	NP_001031.2	Laminin_G_1	75..205	CDD:278483	34/179 (19%)
LpR2	NP_001097928.1	LDLa	193..224	CDD:197566
		LDLa	235..267	CDD:197566
		LDLa	277..313	CDD:238060
		LDLa	356..388	CDD:197566
		LDLa	400..432	CDD:197566
		LDLa	442..476	CDD:238060
		LDLa	484..517	CDD:197566
		FXa_inhibition	527..562	CDD:291342
		EGF_CA	564..594	CDD:214542
		LY	675..715	CDD:214531	10/41 (24%)
		LY	717..760	CDD:214531	9/60 (15%)
		LY	763..803	CDD:214531	9/43 (21%)
		FXa_inhibition	877..918	CDD:291342

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910