Protein Alignment SHBG and LanA

DIOPT Version :9

• Sequence 1: NP_001031.2
• Gene: SHBG / 6462
• HGNCID: 10839
• Length: 402
• Species: Homo sapiens
• Sequence 2: NP_476617.1
• Gene: LanA / 38723
• FlyBaseID: FBgn0002526
• Length: 3712
• Species: Drosophila melanogaster
• Alignment Length: 383
• Identity: 82/383 - (21%)
• Similarity: 137/383 - (35%)
• Gaps: 119/383 - (31%)

Human    76 RTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLH---NHWAQLTVGAGPRLDDGRWHQVEVKME 137
            ||..|.|::.|..:..:||:..:.|.|||...::.   ...|::|..|  .|:||.||.|||...
  Fly  3380 RTERPNGLLIYAGSKQRDDFIAVYLLDGRVTYEIRVGAQLQAKITTEA--ELNDGTWHTVEVVRT 3442

Human   138 GDSVLLEVD-----GEEVLRLRQVSGPLTSKRHPIMRIALGGL-LFPASNLR-----LPLVPALD 191
            ...|.|.:|     |...|...: |.|:.:...||.   |||: .|..|.::     ...||..:
  Fly  3443 QRKVSLLIDKLEQPGSVDLNAER-SAPVLAVELPIY---LGGVNKFLESEVKNLTDFKTEVPYFN 3503

Human   192 GCLRRDSW----LDKQAEISASAPTSLRSCDVESNPGIF-------------LPPGTQA----EF 235
            |||:...:    |:...|.....|     |..:...|:|             ...||:.    :|
  Fly  3504 GCLKNIKFDAMDLETPPEEFGVVP-----CSEQVERGLFFNNQKAFVKIFDHFDVGTEMKISFDF 3563

Human   236 NLRDIPQPHAEPWA------------------FSLDLGLKQAAGSGHLLALGTPENPSWLSLHLQ 282
            ..||   |:...::                  |::...||....:.:.|    |.|.|:.....:
  Fly  3564 RPRD---PNGLLFSVHGKNSYAILELVDNTLYFTVKTDLKNIVSTNYKL----PNNESFCDGKTR 3621

Human   283 DQKVVLSSGSGPGLDLPLVLGLPLQLKLSMSRVVLSQGSKMKALALPPLGLAPLLNLWAKPQGRL 347
            :.:.:.|.         .|:.:.:.. :|.:..|.::||.:.....|                 |
  Fly  3622 NVQAIKSK---------FVINIAVDF-ISSNPGVGNEGSVITRTNRP-----------------L 3659

Human   348 FLGA------LPGEDSSTSF--CLNGLWAQGQRLDVDQALNR------SHEIWTHSCP 391
            |||.      .||..:..||  |::       :::|:|.:..      ..:||...||
  Fly  3660 FLGGHVAFQRAPGIKTKKSFKGCIS-------KVEVNQRMINITPNMVVGDIWQGYCP 3710

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SHBG	NP_001031.2	Laminin_G_1	75..205	CDD:278483	42/146 (29%)
LanA	NP_476617.1	LamNT	18..271	CDD:214532
		EGF_Lam	272..>314	CDD:238012
		EGF_Lam	332..389	CDD:238012
		EGF_Lam	402..443	CDD:238012
		EGF_Lam	448..491	CDD:238012
		Laminin_EGF	495..543	CDD:278482
		Laminin_EGF	541..589	CDD:278482
		Laminin_EGF	587..634	CDD:278482
		EGF_Lam	631..673	CDD:238012
		Laminin_EGF	677..729	CDD:278482
		Laminin_EGF	732..782	CDD:278482
		EGF_Lam	785..828	CDD:238012
		CBM6-CBM35-CBM36_like	831..966	CDD:271143
		Laminin_EGF	1375..1423	CDD:278482
		EGF_Lam	1420..1457	CDD:238012
		Laminin_EGF	1466..1516	CDD:278482
		Laminin_EGF	1514..1562	CDD:278482
		LamB	1632..1760	CDD:214597
		Laminin_EGF	<1775..1801	CDD:278482
		EGF_Lam	1808..1851	CDD:238012
		EGF_Lam	1859..1907	CDD:214543
		EGF_Lam	1916..1968	CDD:238012
		EGF_Lam	1969..2015	CDD:238012
		EGF_Lam	2016..>2054	CDD:238012
		EGF_Lam	2063..>2097	CDD:238012
		Laminin_I	2129..2385	CDD:283627
		Tar	2278..2662	CDD:223910
		Laminin_II	2566..2700	CDD:283628
		LamG	2674..2843	CDD:238058
		LamG	2878..3029	CDD:238058
		LamG	3078..3205	CDD:214598
		LamG	3349..3512	CDD:238058	41/137 (30%)
		LamG	3535..3689	CDD:238058	31/194 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910