DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SHBG and shbg

DIOPT Version :9

Sequence 1:	NP_001031.2	Gene:	SHBG / 6462	HGNCID:	10839	Length:	402	Species:	Homo sapiens
Sequence 2:	NP_001007152.1	Gene:	shbg / 322604	ZFINID:	ZDB-GENE-030131-1324	Length:	381	Species:	Danio rerio

Alignment Length:	428	Identity:	125/428 - (29%)
Similarity:	181/428 - (42%)	Gaps:	101/428 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    12 LLLLL---LLLLLR----------------HTRQGWALRPVLPTQSAHDPPAVHLSNGPGQEPIA 57
            ::|||   |:||.|                |.:|.|.                     |..:..|
Zfish     8 IILLLCPCLILLCRRAAGDQISGRGTINLAHRQQKWT---------------------PAMQTCA 51

Human    58 VMTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRDGRPEIQLHNHWAQLTVGAGP 122
                :|:.|....|.||.||.||||.:|||||....|||:|.||||.||:|:......::|..|.
Zfish    52 ----NLSDIRSIRSFFEFRTLDPEGAVFYGDTKEGQDWFVLSLRDGIPEMQIGKADILVSVKGGR 112

Human   123 RLDDGRWHQVEVKMEGDSVLLEVDGE-EV---LRLRQVSGPLTSKRHPIMRIALGGLLFPASNLR 183
            :|:||.||.:|::.||..|:|||:.| |:   |..:.....||.|    :|:||||:|.....|.
Zfish   113 KLNDGAWHLLELRSEGKFVVLEVNNEVELVVGLHSKLAEEQLTGK----IRLALGGMLVDKQKLF 173

Human   184 LPLVPALDGCLRRDSWLDKQAEISASAPTSLRSCDVESNPGIFLPPGTQAEFNLRDIPQPHAEPW 248
            .|..|.:|.|:|...||:........:....|.|..|...|.:.|....|.||..|:|....|..
Zfish   174 HPFEPEMDACIRGGHWLNLSTPWDTDSTWEPRPCSSEIKKGSYFPGTGVAVFNTSDLPALKTEEA 238

Human   249 AFSLDLGLKQAAGSGHLLALGTPENPSWL--SLHLQ------------DQKVVLSSGSGPGLDLP 299
            ..::::             .|     ||:  :|.||            |.|:.|..||......|
Zfish   239 GITVEI-------------FG-----SWIGTTLSLQSTGFLYVLEGDKDDKLGLKDGSTEFPSEP 285

Human   300 LVLGLPLQLKLSMSRVVLSQGSKMKALALPPLGLAPLLNLWAKPQGRLFLGALPGED---SSTSF 361
            ..|...: ||.|:   |::...|:|:..|      ..|::| |....|..|.:||:.   .|..:
Zfish   286 ATLTFTI-LKNSL---VVNSKPKVKSETL------DFLSMW-KNGMLLTFGGVPGDSEVAKSNPY 339

Human   362 ---CLNGLWAQGQRLDVDQALNRSHEIWTHSCPQSPGN 396
               ||..:..|||.:|:|:|..:...:.:||||....|
Zfish   340 LRGCLEKIVVQGQVIDLDRAAYKHTAVSSHSCPTEAMN 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SHBG	NP_001031.2	Laminin_G_1	75..205	CDD:278483	56/133 (42%)
shbg	NP_001007152.1	LamG	65..191	CDD:304605	55/129 (43%)
shbg	NP_001007152.1	LamG	214..349	CDD:304605	38/163 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I25862
eggNOG	1	0.900	-	-		E1_KOG3927
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H813
Inparanoid	1	1.050	140	1.000	Inparanoid score	I11765
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG42026
OrthoDB	1	1.010	-	-		D1279734at2759
OrthoFinder	1	1.000	-	-		FOG0009324
OrthoInspector	1	1.000	-	-		oto47956
orthoMCL	1	0.900	-	-		OOG6_122021
Panther	1	1.100	-	-	LDO	PTHR24040
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10561
SonicParanoid	1	1.000	-	-		X8858
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	17	17.370