DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SHBG and crb-1

DIOPT Version :9

Sequence 1:NP_001031.2 Gene:SHBG / 6462 HGNCID:10839 Length:402 Species:Homo sapiens
Sequence 2:NP_510822.1 Gene:crb-1 / 181771 WormBaseID:WBGene00000792 Length:1722 Species:Caenorhabditis elegans


Alignment Length:478 Identity:91/478 - (19%)
Similarity:165/478 - (34%) Gaps:162/478 - (33%)


- Green bases have known domain annotations that are detailed below.


Human    30 LRP----VLP-TQSAH--DPPAVHLSNGPGQEPIAVMTFDLTKITKTSSSFEVRTWDPEGVIFY- 86
            |:|    .|| |...|  .|..||||....:..:.....:|        ||.:.:..|:.|:|| 
 Worm   745 LKPNCVYFLPKTTFGHLDQPSIVHLSTSESENHLLRNHIEL--------SFLMHSGKPDAVLFYI 801

Human    87 GDTNPKD---DWFML----GL------RDGRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEG 138
            |:.:..|   ::.::    ||      ..||.||:.         .:..|:||.:.|.|::.::.
 Worm   802 GEKHAADVLTNYLVVKIAGGLITVRYRTGGRREIEF---------SSKNRVDDNQEHHVQIFLDK 857

Human   139 DSVLLEVDGEEVLRLRQVSGPLTSKRHPIMRIALGGLLFPASNLRLPLVPALD-----GCLRRDS 198
            .:..:.:|.     |.:.|.|:.|:..  ....:..::..|||     |.|.|     |.| :|.
 Worm   858 TTRQIIIDD-----LIECSEPIISRMS--QEFYVDDIVIGASN-----VVATDSEFYKGYL-QDI 909

Human   199 WLDKQAEISASAPTSL------------------------------------------------- 214
            .:::::.:  ..||||                                                 
 Worm   910 QINQKSVV--IHPTSLTIDKIGKLERTQNVIEGAVSDPMCSSSTCKHGECSETFNDFTCRCSDGS 972

Human   215 --RSCD----------------VESNPG------IFLPPGTQAEFNLRDIPQPHAEPWAF----S 251
              :.||                ..::.|      |.:..|:...::|        .|..|    |
 Worm   973 TGKLCDKVDYCKDASCMKGSRCENADNGHYCIFPITISNGSMLTYSL--------APTKFMTLPS 1029

Human   252 LDLGLKQAAGSGHLLALGTPENPSWLSLHLQDQKVVLSSGSGPG----LDLPLVLGLPLQLKLSM 312
            ::..:|..:.:||:..|..  :.|.||.:|..:::.|::.||.|    .|..:..|...|:.|:.
 Worm  1030 IEFSIKAHSQNGHIFTLTI--DKSTLSAYLFKKRLALATNSGSGTIQKFDSVIADGNWHQIILNP 1092

Human   313 SRVVLSQGSKMKALALPPLGLAPLLNLWAKPQGRLFLGALPGEDSSTSFCLNGLWAQGQ--RLDV 375
            .:|::.....:....|.|..        :|....||:|  ..|....:|....|:..|:  .|..
 Worm  1093 HKVLIDSVKFISDNQLYPAE--------SKSGASLFVG--EQEPQEVTFACLDLFKMGEYPTLSF 1147

Human   376 DQA-LNRSHEIWTHSCPQSPGNG 397
            .:. :..:.|.|..:...|.|.|
 Worm  1148 TKVKIPTNSETWNLTDKASVGTG 1170

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SHBGNP_001031.2 Laminin_G_1 75..205 CDD:278483 31/148 (21%)
crb-1NP_510822.1 EGF_CA <132..161 CDD:238011
EGF_CA 163..199 CDD:238011
EGF_CA 408..439 CDD:238011
Laminin_G_2 582..694 CDD:280389
LamG 760..912 CDD:238058 40/181 (22%)
LamG 1029..>1088 CDD:304605 15/60 (25%)
EGF_CA 1175..1210 CDD:238011
EGF_CA 1482..1517 CDD:238011
EGF_CA 1519..1556 CDD:238011
EGF_CA 1558..1593 CDD:238011
PHA03099 <1613..1682 CDD:165381
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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