Protein Alignment GIGYF1 and Gyf

DIOPT Version :10

• Sequence 1: NP_001362688.1
• Gene: GIGYF1 / 64599
• HGNCID: 9126
• Length: 1076
• Species: Homo sapiens
• Sequence 2: NP_001162827.1
• Gene: Gyf / 43842
• FlyBaseID: FBgn0039936
• Length: 1574
• Species: Drosophila melanogaster
• Alignment Length: 1690
• Identity: 363/1690 - (21%)
• Similarity: 544/1690 - (32%)
• Gaps: 781/1690 - (46%)

Human     4 ETLNFGPEWLRALSGGGSVASPPPSPAMPKYKLA---------------------------DYRY 41
            :::.|||||||.:|     |.|..||:  .|.:.                           :|||
  Fly     3 DSMKFGPEWLRNMS-----AEPSGSPS--TYNVGNAAQNNSIGGHNLGNNTAASASRNLFPEYRY 60

Human    42 GREEMLALYVKENKVPEELQDKEFAAVLQDEPLQPLALEPLTEEEQRNFSLSVNS-VAVLRLMGK 105
            ||||||:|:.:...:|:.|  ..|..:..::...||||.|.:||:....||..|| .|.|:....
  Fly    61 GREEMLSLFDRNCLLPQIL--PSFKKLFVEKVQCPLALTPSSEEDINQNSLGNNSRPAWLQRSPS 123

Human   106 GAGPPLAGTSRGRGSTRSRGRGRGDSCF---YQRSIEEGDGAFGRSPREIQRSQ-SWDDRGERRF 166
            |.|....|:  |||.|..|||.||.|.:   |||.    .|.:..|...|.::: :|.||
  Fly   124 GFGSASRGS--GRGGTVDRGRMRGKSAYHPIYQRP----SGLYDESLSVISKAERTWSDR----- 177

Human   167 EKSARRDGARCGFEEGGAG-----------PRKEHARS--DSENWRSLREEQEEEEEGSWRLGAG 218
              :...|.|.......|:|           |||:::.:  :.||||..|     .|:||   |.|
  Fly   178 --NGTGDSAATTTSTSGSGALDWNGTPSSSPRKDYSNNHRNLENWRRTR-----NEDGS---GDG 232

Human   219 PRRDGDR-------WRSASPDGGP------------RSAGWREH-------GERRRK------FE 251
            |...|..       |||....|..            ||..||:.       ...:|.      ..
  Fly   233 PSSSGSMSGPDIAGWRSGVVGGSTNAGFGTNSHRWGRSTSWRDEDPSVDNAASLQRSISTVATLS 297

Human   252 FDLRGDRGGCGEEEGRGGGGSSHLRRCRA----------PEGFEEDKDGLPEWCLDDEDEEMGTF 306
            .|..|:..|.|.....|.|..||.|...:          ..|.:.| :.||||.:::..:..|:|
  Fly   298 TDRTGNNKGSGIGAAEGVGSISHPRLSSSKISQLWTVNNAAGVDAD-ENLPEWAIENPSKLGGSF 361

Human   307 DASGAF------LPLKKGPKEPIPEEQELDFQGLEEEEE----PSEGLEEEGPEAGGKELTP--- 358
            ||||||      .|:|.       ....|..:.|:..::    .|:.|.:  |:: |.::||
  Fly   362 DASGAFHGDTDLKPIKS-------SHNTLKTKSLDSYDDVKRPKSKDLSD--PDS-GNDITPETS 416

Human   359 -------LPPQEEKSSSPSPLPTLGPLWGTNGDGDETAEKEPPAAEDDIRGIQLSPGVGSSAGPP 416
                   ...|||..||.||:             ..|..||.                     ..
  Fly   417 LTKDTNTTAVQEEVESSLSPI-------------SSTTTKEV---------------------IH 447

Human   417 GDLEDDEGLKHLQQEAEKL-------VASLQDSSLEEEQFTAA---------------------- 452
            ||:.|  .:|.:..|.|||       ::|.|......:.||||
  Fly   448 GDISD--RIKEVADEVEKLIMDDDHKISSNQSQHQNHDGFTAALPRMADIEINVKPSVTAVHRQA 510

Human   453 ------------------------------MQTQGLRHSAAATALPLSH----GAARKWFYKDPQ 483
                                          ||...:.|......:|..|    .....|||:|||
  Fly   511 PSTMPIQITPTITDVAPPSHAVVSFSDHETMQHHNMHHLPQFPMIPTPHIITPNLNELWFYRDPQ 575

Human   484 GEIQGPFTTQEMAEWFQAGYFSMSLLVKRGCDEGFQPLGEVIKM-WGRVPF-------------- 533
            ..:||||:..||.||::||||:.:|.|:|..|..|:||||:||. .|.:||
  Fly   576 ANVQGPFSAVEMTEWYRAGYFNENLFVRRYSDNRFRPLGELIKFCHGNMPFTHSHLLPSPIELEN 640

Human   534 -------AP----------GPSPPPLLGNMDQERLKKQQ------------ELAAAALY------ 563
                   ||          .|||.|:..::.:::|::|:            |...||:.
  Fly   641 IPVGQIPAPLTASLSITPHKPSPIPIALSVVEQQLQQQRDEQLKANVTATAEALRAAIKGSFGGN 705

Human   564 ------------------QQLQHQQF--------------------------------------- 571
                              |.:|||::
  Fly   706 SIGNTSHLLTMRFQMLQDQYIQHQEYQILAELSKNECFQRLSAVEQETVVRRKVQLLGLPEYLIS 770

Human   572 ----------LQLVSSRQLPQCAL--------------REKAALG-------------------- 592
                      |..|:.|||.:..:              .::.::|
  Fly   771 LNGLSNSLSVLNPVAGRQLYRAVVEHAKKDQQHIFANTEQQRSVGNLLDANNFILNAQIMIQQSQ 835

Human   593 --------------------DLTPP----------------------PPPPPQQQQQQLT----- 610
                                ||..|                      .|...|||...||
  Fly   836 QEVGPLVSSVDCIMQGGTAADLNKPNEIPRNELDLINEYNLRMLLRGQPTSTQQQPPALTNSATE 900

Human   611 -----AFLQQLQALKPPRGGDQNL-----LPTMSRSLSVPDSGRLWDVHTSASSQSGGEASLWD- 664
                 .||.:.|.|:     .|||     ||        |::.:..:.....:..|..:||||:
  Fly   901 NLPGVDFLTETQLLE-----RQNLMIPIWLP--------PNNNKQQETDQQWAEMSNADASLWET 952

Human   665 ------------IPINSSTQG-------------------------PILEQLQL----------- 681
                        :.|..|::.                         ..||:|..
  Fly   953 ANLNEERNEDQQLLIQKSSEACFADTEKDVKIAQLFQVQSGNVVNHTALEELDQSPQNLKGSHNQ 1017

Human   682 ---------------------QHKFQERREVELRA------------------KREE-EERKRRE 706
                                 ||:.::..:..|..                  |||: ||:||:.
  Fly  1018 KIVKSLVSDIQQNHNEELNSHQHQVKQANKQNLNTKQNAAQSALKPINNENDRKREQTEEKKRQR 1082

Human   707 EKRRQQQQEEQKRR------------QEEEELFRRKHVRQQELLL-------------------- 739
            |:|::||.|:.|||            |||:|..::...::::.||
  Fly  1083 EERKRQQLEDDKRRALNESEEQTRQIQEEKERQQQIQAQRRKALLGNVHSLSVQNGMSGTLASAQ 1147

Human   740 -------KLLQQQQAVPVPPAPSSPPPLWA-----------GLA--------------------- 765
                   |..:.|.:..:|....:|   |:           |||
  Fly  1148 SKKNDDAKTAEPQVSSRLPSTSVAP---WSFQLQNSMRSAPGLAEIQKAERRERRADQQRHQELL 1209

Human   766 -KQ-----------------------GLSMKTLLELQLEGERQLHKQPPPREPARAQAPNHRVQL 806
             ||                       ...:.:|.|:|.|..|:|......|: .|.:..:|:
  Fly  1210 DKQLRANAAAAAEANDALLKWQSTPASAPVMSLAEIQAEEARRLANDLVDRQ-RRRELEHHQ--- 1270

Human   807 GGLGTAPLNQWV---SEAGPLWGGPDKSGGG----------SSGLGLWEDTPKSGGS-------- 850
                .|||:..|   |....:||..:|:...          |||.||| |.|...||
  Fly  1271 ----QAPLSSAVLVTSATSNIWGNANKAWSSSAAQSLSLKTSSGTGLW-DEPNPLGSNGSGTSGT 1330

Human   851 --------LVRGL----------------------GLKNSRSSPSLSD-SYSHLSG---RPIRKK 881
                    |..||                      .|:.|::.|:||: ..|:.:|   ||.::|
  Fly  1331 SSVTAAAVLAGGLNSANKSTLQAQNKSSALFASPRNLRKSQTLPALSNPEKSNKNGPGQRPEKQK 1395

Human   882 ------------TEEEEKLLKL------------LQGIPRPQDGFTQWCEQMLHTLSATGSLDVP 922
                        .||:::..||            :..:...::.||.||.:.|..:||  .:|||
  Fly  1396 LAQTRSKGAAVSIEEKDRERKLNAKSQQSSTDQAISKVNEYENEFTSWCIKSLDNMSA--KVDVP 1458

Human   923 MAVAILKEVESPYDVHDYIRSCLGDTLEAKEFAKQFLERRAKQKASQQRQQQQEAWLSSASLQTA 987
            ..||.|:::|:||:|.||:|..|||..::.:|||||||||:|.|                |||.|
  Fly  1459 TFVAFLQDLEAPYEVKDYVRIYLGDGKDSLDFAKQFLERRSKYK----------------SLQRA 1507

Human   988 FQANHSTKLGPGEG----------SKAKRRAL----MLHSDPSILGELGWGRSGTSLAQGRRSPG 1038
            .:|::.....|...          ||.|::.:    |...|..|||      ...:.|:||.:.|
  Fly  1508 QKAHNDDMCKPAPAITPSANDYADSKNKQKKIKKNKMTKMDARILG------FSVTAAEGRINVG 1566

Human  1039  1038
              Fly  1567  1566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GIGYF1	NP_001362688.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	105..422		95/395 (24%)
		GYF	476..529	CDD:238027	29/53 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	621..640		5/23 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	696..724		17/40 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	825..879		25/105 (24%)
Gyf	NP_001162827.1	GYF	569..613	CDD:460496	23/43 (53%)
		Mplasa_alph_rch	<931..>1113	CDD:275316	31/181 (17%)