DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nphs1 and side-III

DIOPT Version :9

Sequence 1:NP_072150.1 Gene:Nphs1 / 64563 RGDID:620460 Length:1252 Species:Rattus norvegicus
Sequence 2:NP_001036681.1 Gene:side-III / 4379844 FlyBaseID:FBgn0083949 Length:1689 Species:Drosophila melanogaster


Alignment Length:1359 Identity:274/1359 - (20%)
Similarity:417/1359 - (30%) Gaps:479/1359 - (35%)


- Green bases have known domain annotations that are detailed below.


  Rat     3 AKRVTVRGARTS---PIHRTS-SLTPLLLMG---MLTSGLA-----ESPVPTSAPQGFWALSENL 55
            |||.:.....||   .|.|:. :|..|.|..   .||||..     :.||.|.|          :
  Fly     5 AKRTSTMPLTTSYNANIRRSCLALFALFLFAAHISLTSGQIDWDDDDDPVSTVA----------V 59

  Rat    56 TAVEGTTVKLWCGVRAPGS-----VVQWAKDGLLLGPNPKMPGFPRYSLE--------------- 100
            .||.|.|..|.|.:.....     :|.|.::.         .|.|.||.:               
  Fly    60 EAVLGRTASLPCDIEPEAKDDRVYMVLWFRES---------AGKPLYSFDVRGRPFEKALYWSDT 115

  Rat   101 ---GDRA-----KGEFHLLIEACDLSDDAEYECQVGRSELGPELVSP----KVILSILVSPKVLL 153
               |.||     :....|.::...|.|:..|.|:|....      ||    ::.|:::|.|..:|
  Fly   116 NSFGPRAYFVTGQQPAKLSVDNIQLDDEGVYRCRVDFQN------SPTRNHRINLTVIVPPHQIL 174

  Rat   154 LTPEAGSTVTWVAGQEYVVTCVSGDAKPAPDITFIQSGRTILDVSSNVNEGSEEKLCITEAEARV 218
            :...:|..|....|                                                   
  Fly   175 VYDASGRDVAGAVG--------------------------------------------------- 188

  Rat   219 IPQSSDNGQLLVCEGSNPALDTPIKASFTMNILFPPGPPVIDWPGLNEGHVRAGENLELPCTARG 283
                                                  |:::           |:|:.|.|..||
  Fly   189 --------------------------------------PLLE-----------GDNIVLTCEVRG 204

  Rat   284 GNPPATLQWLKNGKPVSTAWGT-----------EHAQAVAHSVLVMTVRPEDHGARLSCQSYNSV 337
            |.|..|:.|:...:.:....|.           |.|| ::.|.|..|.|         ||:.|:.
  Fly   205 GRPEPTVTWMNGTRTLEAGSGVSMGRHVTVNRLEVAQ-ISRSALNNTYR---------CQASNTK 259

  Rat   338 SAGTQERSITLQVTFPPSAITILGSVSQ-SENKNVTLCCLTKSSRPRVLLRWWLGGRQ----LLP 397
            .....||||.:::...|:::.:...:.. :.|....|.|:...|.|...::|....|.    ||.
  Fly   260 LVAPVERSIRIEMLLKPTSVNLTNKLKVFASNTQYNLTCIVAGSVPDTEIKWTQNNRPFKRGLLS 324

  Rat   398 TDETVMDGLHGGHISMSNLTFLVRREDNGLPLTCEAFSDAFSKETFKKSLTLNVKYPAQKLWIEG 462
            |.::      .|.: :|.|||..:.||:|..|.||..:........:.||.:||.||.|.....|
  Fly   325 TSQS------NGRV-ISTLTFYPQPEDDGTMLKCEGSNPRLQNSAIEDSLMMNVIYPPQVTLSLG 382

  Rat   463 P---PEGQYIRTGTRVRLVCLAIGGNP-DPSLIWFKDSRPVSEPRQPQEPRRVQLGSVEKSGSTF 523
            .   |:.  |:.|..|...| .|..|| :..::|..|.:||::        .|..|.:     ..
  Fly   383 STLRPDD--IKEGDDVYFEC-HIKSNPKEHRIMWSHDGQPVTQ--------NVSWGII-----IS 431

  Rat   524 SRELVLIIGPPDNRAKFSCKAGQLSASTQLVVQFPPTNLTI-----LANSSALRPGDALN----L 579
            :|.|||......:...::|.|......||..    |.||.|     .::||....|.:|.    :
  Fly   432 TRSLVLQRVGRIHSGFYACSAANDRGETQSA----PVNLRIRYAPVCSSSSITVIGASLEEDVPI 492

  Rat   580 TCVSISSNPP-VNLSW--DKEGERLE----DVAAKPQSAPFKGSAASRSVFLRVSSRDHGQRVTC 637
            .| .::|:|| ::..|  ...||..|    ..|..........|...|:|   |.|.:       
  Fly   493 PC-RVNSDPPEIDFEWTFSTSGEHFEVPSGHYATIQDPTMTTTSDVRRTV---VESNE------- 546

  Rat   638 RAHSEALRETVSSFYRFNVLYPPEFLGEQVRAVTVVEQGQVLL----PVSVSANPAPEAFNWTFR 698
             .|.|:..||||     .::|.|:  ||:       :.|.:..    .:...::|..        
  Fly   547 -THFESYVETVS-----ELIYTPK--GER-------DYGTLACYGRNAIGKQSDPCV-------- 588

  Rat   699 GYRLSPAGGPRHRILSGGALQLWNVTRADDGFYQLHCQNSEGTAEALLKLDVHYAPTIRALRDPT 763
             :::.||..|       |||:  |.|...                        |..|..:|....
  Fly   589 -FQVVPAAKP-------GALR--NCTLRP------------------------YVVTSASLNSSN 619

  Rat   764 EVNVGGSVDIVCTVDANPILPEMFSWERLGEEEEDLNLDDMEKVSKGSTGRLRIRQAKLSQAGAY 828
            :.          |:.||.|||..:     |..|.  |...||.|          |:...|..|. 
  Fly   620 QT----------TMHANQILPTQY-----GRHES--NYPHMEYV----------RERHNSSGGN- 656

  Rat   829 QCIVDNGVAPAA----------RG------------------LVRLVVR--FAP----------- 852
                :||.||||          ||                  |.||..|  |.|           
  Fly   657 ----NNGTAPAAGRNNVANKNMRGRTSAGQAKSNNKQLTQQQLQRLKKRTSFTPSQTLAAIERQR 717

  Rat   853 ---QVDQPT--------PLTKVAAAGDSTSSATLHCRARGVPNIDFTWTKNGVPLDLQDPRYTEH 906
               |:.|..        ..|...:.||:        :..|.|...   :|..:....:||:..:.
  Fly   718 QRKQLSQQQQQLQQQHHQATATKSGGDN--------KPDGSPAKS---SKQRMRRASRDPQIQQQ 771

  Rat   907 RYHQGVVHSSLLTIANVSAAQDYALFKCTATNALG-----------SDHTNIQLVSISRPDPPLG 960
            :.||......|....:::::|........:|:.||           |..:||...|.:...|...
  Fly   772 QQHQQQQQHQLHAATSITSSQRKQAESNLSTSHLGKGSSSSSRSRRSSSSNINSKSNNGKQPAKY 836

  Rat   961 L----KVVSISPHSVGLEWKPGFDGGLPQRFQIRYEALET-----PGFLHVDVLPTQATTFTLTG 1016
            .    |.:....|...|:...|............|.||.:     ......|:|.|.|...|...
  Fly   837 FNKRQKNMHKQKHQQKLKQLKGTTNEHNSNIIHHYAALSSSLRRRKRLAANDILATVAAASTSAS 901

  Rat  1017 LKPSTRYRIWLLASNA----------------LGDSGLTDKGIQVSVTTPGPDQAPEDTDHQLPT 1065
            |..........||:.|                ..|||..:|..:.|:|.. ..|..:....||  
  Fly   902 LSSPPASSAASLAATATAAVEIEQDVSAVDAPAADSGSNNKRSRKSLTIL-DKQKQQQEQQQL-- 963

  Rat  1066 ELPPGPPRLPLLPVLFAVGGLLLLSNASCVGGLLWRRRLRRLAEEISEKTEAGSEDRIRNEYEES 1130
             |||..|::...||....|..:..:.|:...|        .:|..:.:|..:..||...|:.:..
  Fly   964 -LPPNAPQISNQPVAAISGNNVKETAATSAHG--------AVAAGVKDKAPSSKEDSTDNDNDSD 1019

  Rat  1131 QWTGDRDTRSSTVSTAEVDPNYYSMRDFSPQLPPTLEEVLYHQGAEGEDMAFPGHLHDE 1189
               ||.|........||:|                 .|...:...|.||..  |..||:
  Fly  1020 ---GDEDDDDDDDDGAEID-----------------AETETNDEEEDEDEG--GEAHDD 1056

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nphs1NP_072150.1 Ig 52..128 CDD:299845 20/103 (19%)
IG_like 52..127 CDD:214653 20/102 (20%)
C2-set_2 155..242 CDD:285423 3/86 (3%)
Ig_3 256..335 CDD:290638 21/89 (24%)
IG_like 268..350 CDD:214653 25/92 (27%)
C2-set_2 358..440 CDD:285423 21/86 (24%)
I-set 460..555 CDD:254352 23/98 (23%)
Ig 472..555 CDD:299845 20/83 (24%)
Ig 563..646 CDD:299845 21/98 (21%)
IG_like 670..750 CDD:214653 10/83 (12%)
Ig 676..750 CDD:299845 10/77 (13%)
Ig_3 753..834 CDD:290638 17/80 (21%)
IG_like 762..848 CDD:214653 26/113 (23%)
Ig 848..956 CDD:299845 24/142 (17%)
IG_like 859..949 CDD:214653 18/100 (18%)
FN3 955..1049 CDD:238020 22/118 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1043..1067 5/23 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1113..1144 7/30 (23%)
side-IIINP_001036681.1 IG_like 59..166 CDD:214653 24/121 (20%)
V-set 59..166 CDD:284989 24/121 (20%)
ig 190..268 CDD:278476 23/98 (23%)
IG_like 192..259 CDD:214653 21/87 (24%)
Ig 296..361 CDD:299845 20/71 (28%)
IG_like 391..468 CDD:214653 23/94 (24%)
IGc2 392..454 CDD:197706 18/75 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3515
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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