Protein Alignment SH3GL2 and mug137

DIOPT Version :10

• Sequence 1: XP_011516307.1
• Gene: SH3GL2 / 6456
• HGNCID: 10831
• Length: 386
• Species: Homo sapiens
• Sequence 2: NP_588493.1
• Gene: mug137 / 2539113
• PomBaseID: SPCC1919.11
• Length: 420
• Species: Schizosaccharomyces pombe
• Alignment Length: 356
• Identity: 91/356 - (25%)
• Similarity: 169/356 - (47%)
• Gaps: 56/356 - (15%)

Human    52 SEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLSMINTMSKIRGQEK 116
            :||..|.:...|.|.|.|:|:::.:....:.::...|..::.            :.:.|:.|::|
pombe    10 NEKPLGDQRAHLPDSFLELEQEIAIREEGLSKLFQATTIWID------------SILKKVDGEDK 62

Human   117 GPGYPQAEALLA-----EAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDIEVKQNFIDP 176
                   |..||     :.|:...:||..|.::|..|.::|:|..::.|.:.||..:.:..::|.
pombe    63 -------EKCLACENLGKVMINHSKELPQDSSYGITLSQLGKANLKIGEHQTSLAYKARVCYLDF 120

Human   177 LQN--LHDKDLREIQHHLKKLEGRR------LDFDYKKKRQGKIPDEELRQALEKFDESKEIAES 233
            |:.  :..||....:   ||||.||      |...:|:|::....:|::|.||.||:||.|..::
pombe   121 LKRYLVQAKDFHSAR---KKLESRRQAYESLLQKSFKEKKEDSRLEEDIRLALYKFEESTEQVKN 182

Human   234 SMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQIL-----QQVTVRLEERIRQASSQPRREYQPK- 292
            .|..|.:::.:|..||:.|:..:|.:.|::..||     .|.::..:::|:.:......|:...
pombe   183 RMIALKDVEADQYQQLTELIVYELNFFKESTGILNTIFNSQNSLTPQKKIQSSERSVENEFLASP 247

Human   293 --PRMSLEFPTGDSTQPNGGLSHT--GTPKPSGVQMDQPCCRALYDFEPENEGELGFKEGDIITL 353
              |.:|..|....:|:.   :|.|  .|||... :.:....:|:|.|...||.||....||:|.:
pombe   248 MDPSLSKLFTKTTNTEK---ISPTPFSTPKRKS-KKETVFVKAIYSFTGRNEKELDLHTGDVIQV 308

Human   354 TNQIDENWYEG-------MLHGHSGFFPINY 377
            :.|:..:||.|       ...|:||.||:||
pombe   309 SEQLGPDWYMGEKVNSKAEKLGNSGMFPVNY 339

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SH3GL2	XP_011516307.1	BAR_Endophilin_A1	59..281	CDD:153297	57/239 (24%)
		SH3_Endophilin_A	327..381	CDD:212737	21/58 (36%)
mug137	NP_588493.1	BAR_MUG137_fungi	17..230	CDD:153277	56/234 (24%)
		SH3	280..341	CDD:214620	21/60 (35%)