DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SH3GL2 and unc-57

DIOPT Version :10

Sequence 1:XP_011516307.1 Gene:SH3GL2 / 6456 HGNCID:10831 Length:386 Species:Homo sapiens
Sequence 2:NP_001122513.1 Gene:unc-57 / 172078 WormBaseID:WBGene00006791 Length:381 Species:Caenorhabditis elegans


Alignment Length:377 Identity:165/377 - (43%)
Similarity:245/377 - (64%) Gaps:38/377 - (10%)


- Green bases have known domain annotations that are detailed below.


Human    41 RLERCYQHLKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLSMI 105
            :..:..|:|  ||.:|.||.|||||.|.|||:.||.|...:.:::..|.||||||||:|||::..
 Worm     9 QFNKANQYL--SETMGAAEPTKLDDVFNEMEKNVDTTYNLITDLVAGTNEYLQPNPATRAKMATQ 71

Human   106 NTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDIEVK 170
            ..:||:||..|...|||.|.:||:.|.|:|::|||:.:.|.:|.:..|..|:::::|..::..||
 Worm    72 VALSKVRGTTKTSPYPQTEGMLADVMQKYGQQLGDNSDLGKSLNDAAETYRQMADIKYQMEDNVK 136

Human   171 QNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFDESKEIAESSM 235
            |||:|||.:|.:.:|:::.||..||:|||||:|.||::|.:  |:|:.||.||.:|||.:||.||
 Worm   137 QNFLDPLTHLQNNELKDVNHHRTKLKGRRLDYDCKKRQQRR--DDEMIQAEEKLEESKRLAEMSM 199

Human   236 FNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQP--------- 291
            ||:|..|:||:|||.||::|||::|:|..|.|:.:..:|..||:.|:::||.|:.|         
 Worm   200 FNVLSNDVEQISQLRALIEAQLDFHRQTAQCLENLQQQLGHRIKDAAARPREEHVPLSVLANESR 264

Human   292 KPRMSLEFP-----TGDST---------QPNGGL-----SHTGTPKPSGV-----QMDQPCCRAL 332
            .||.|...|     :.:||         |..||:     |:.| |.|.|:     |..:|.||||
 Worm   265 TPRSSFRSPAPSDMSHNSTAAAAFKMPPQNGGGITQAPPSYQG-PPPGGLPPPLSQQQKPQCRAL 328

Human   333 YDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVAL 384
            :||:.::||||.||||.:|.|.:|||||||||.::|.:|.||:.||::||.|
 Worm   329 FDFDAQSEGELDFKEGTLIELVSQIDENWYEGRVNGKTGLFPVTYVQVLVPL 380

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SH3GL2XP_011516307.1 BAR_Endophilin_A1 59..281 CDD:153297 104/221 (47%)
SH3_Endophilin_A 327..381 CDD:212737 32/53 (60%)
unc-57NP_001122513.1 BAR_Endophilin_A 25..245 CDD:153276 104/221 (47%)
SH3_Endophilin_A 323..377 CDD:212737 32/53 (60%)

Return to query results.
Submit another query.