Protein Alignment SH3GL2 and Sh3gl2

DIOPT Version :10

• Sequence 1: XP_011516307.1
• Gene: SH3GL2 / 6456
• HGNCID: 10831
• Length: 386
• Species: Homo sapiens
• Sequence 2: NP_446387.1
• Gene: Sh3gl2 / 116743
• RGDID: 620276
• Length: 352
• Species: Rattus norvegicus
• Alignment Length: 337
• Identity: 332/337 - (98%)
• Similarity: 334/337 - (99%)
• Gaps: 0/337 - (0%)

Human    50 KVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLSMINTMSKIRGQ 114
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    16 KVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLSMINTMSKIRGQ 80

Human   115 EKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDIEVKQNFIDPLQN 179
            ||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||
  Rat    81 EKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDMEVKQNFIDPLQN 145

Human   180 LHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIE 244
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   146 LHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIE 210

Human   245 QVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNG 309
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||.|||||
  Rat   211 QVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQPKPRMSLEFATGDGTQPNG 275

Human   310 GLSHTGTPKPSGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFP 374
            ||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||.|||||
  Rat   276 GLSHTGTPKPAGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGQSGFFP 340

Human   375 INYVEILVALPH 386
            ||||||||||||
  Rat   341 INYVEILVALPH 352

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SH3GL2	XP_011516307.1	BAR_Endophilin_A1	59..281	CDD:153297	220/221 (100%)
		SH3_Endophilin_A	327..381	CDD:212737	52/53 (98%)
Sh3gl2	NP_446387.1	Binds and tubulates liposomes	1..125		108/108 (100%)
		Membrane-binding amphipathic helix	1..21		4/4 (100%)
		BAR_Endophilin_A1	25..247	CDD:153297	220/221 (100%)
		Required for dimerization upon membrane association	60..87		26/26 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	246..289		39/42 (93%)
		SH3_Endophilin_A	293..347	CDD:212737	52/53 (98%)