DRSC/TRiP Functional Genomics Resources

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Protein Alignment ITSN1 and EDE1

DIOPT Version :10

Sequence 1:NP_003015.2 Gene:ITSN1 / 6453 HGNCID:6183 Length:1721 Species:Homo sapiens
Sequence 2:NP_009506.1 Gene:EDE1 / 852233 SGDID:S000000143 Length:1381 Species:Saccharomyces cerevisiae


Alignment Length:1511 Identity:295/1511 - (19%)
Similarity:504/1511 - (33%) Gaps:513/1511 - (33%)


- Green bases have known domain annotations that are detailed below.


Human     4 FPTPFGGSLDIWAITVEERAKHDQQFHSLKPIS-GFITGDQARNFFFQSGLPQPVLAQIWALADM 67
            |.||         ::.:|:|.::|:||.|.... |.:||:..|..|..||||..:|:|:||..|:
Yeast     6 FRTP---------LSSQEQAFYNQKFHQLDTEDLGVVTGEAVRPLFASSGLPGQLLSQVWATVDI 61

Human    68 NNDGRMDQVEFSIAMKLIKLKLQG----------YQ-LPSALPPV-MKQQPVAISSAPAFGMGGI 120
            :|.|.::..|||.|:::| .:||.          |: .|:.|... :.|.|..:.|..|.|....
Yeast    62 DNKGFLNLNEFSAALRMI-AQLQNAPNQPISAALYESTPTQLASFSINQNPAPMQSGSATGNTNN 125

Human   121 ASMPPLTA--VAP-------VPMGSIPVVG----------------------------------- 141
            ..:|.|::  :|.       ...|:..|.|                                   
Yeast   126 TDIPALSSNDIAKFSQLFDRTAKGAQTVAGDKAKDIFLKARLPNQTLGEIWALCDRDASGVLDKS 190

Human   142 ---MSPTLVS---------SVPTAAVP----------PLANGAPPVIQPLPAFAHPAATLPKSSS 184
               |:..|:.         :.|.|.:|          |:....|....||.|.:...::|.:.|:
Yeast   191 EFIMAMYLIQLCMSHHPSMNTPPAVLPTQLWDSIRLEPVVVNQPNRTTPLSANSTGVSSLTRHST 255

Human   185 FSRSGPGSQLNTKLQKAQSFDVASVPPVAEWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTIL 249
            .||...|:..|.               .::|::....:.::..:|:|.||..:|.|:........
Yeast   256 ISRLSTGAFSNA---------------ASDWSLSFEKKQQFDAIFDSLDKQHAGSLSSAVLVPFF 305

Human   250 MQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLPPE---------YIP 305
            :.|.|.|..||:||:|:||..:.:.|..||.:||.||....:|..||.|:|.|         |.|
Yeast   306 LSSRLNQETLATIWDLADIHNNAEFTKLEFAIAMFLIQKKNAGVELPDVIPNELLQSPALGLYPP 370

Human   306 PSFRRVRSGSGISVISSTS---------------------VDQRLPE------------------ 331
            ....:.:|...|::.|..|                     |.|.||:                  
Yeast   371 NPLPQQQSAPQIAIPSRASKPSLQDMPHQVSAPAVNTQPTVPQVLPQNSNNGSLNDLLALNPSFS 435

Human   332 -------EPVLED-----------------EQQQLEKKLPVTFEDKKRENFERGNLELEKRRQAL 372
                   :.|:::                 :|||.::..|:|......:.|    .......|::
Yeast   436 SPSPTKAQTVVQNNTNNSFSYDNNNGQATLQQQQPQQPPPLTHSSSGLKKF----TPTSNFGQSI 496

Human   373 LEQQRKEQERL------------------------------------------------------ 383
            ::::.:|||:|                                                      
Yeast   497 IKEEPEEQEQLRESSDTFSAQPPPVPKHASSPVKRTASTTLPQVPNFSVFSMPAGAATSAATGAA 561

Human   384 -----------------------------------AQLERAEQERKERERQEQERKRQLELEKQL 413
                                               |||..|..|......|          ...|
Yeast   562 VGAAVGAAALGASAFSRSSNNAFKNQDLFADGEASAQLSNATTEMANLSNQ----------VNSL 616

Human   414 EKQRELERQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKK--K 476
            .||..:...::....:|::|    ..|::...|::....|.....|.:..||.:..||:..|  :
Yeast   617 SKQASITNDKKSRATQELKR----VTEMKNSIQIKLNNLRSTHDQNVKQTEQLEAQVLQVNKENE 677

Human   477 TLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITH-------LQQQLQES 534
            ||..:|.......|..|.||.:    |||..|  ||..|:.||: .:||:       ||.||.|.
Yeast   678 TLAQQLAVSEANYHAAESKLNE----LTTDLQ--ESQTKNAELK-EQITNLNSMTASLQSQLNEK 735

Human   535 QQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQE 599
            ||.:.:   |:.:::...||::.|.      ||:.                  .::||.....::
Yeast   736 QQQVKQ---ERSMVDVNSKQLELNQ------VTVA------------------NLQKEIDGLGEK 773

Human   600 IDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHV 664
            |.::..:.|||.: :.|...::...::|:......::..:.:.|||.||..|:.:|::..:.:||
Yeast   774 ISVYLTKQKELND-YQKTVEEQHAQLQAKYQDLSNKDTDLTDREKQLEERNRQIEEQENLYHQHV 837

Human   665 QQ-----EDEHQRPRKLHEEEKLKREESVKKKDG-EEKGKQEAQDKLGRLFHQHQE-PAKPAVQA 722
            .:     :|..||.....:.::..:|.:::..:. .|..:::....:|:|....:: .||.|...
Yeast   838 SKLQEMFDDLSQRKASFEKADQELKERNIEYANNVRELSERQMNLAMGQLPEDAKDIIAKSASNT 902

Human   723 PWSTAE---KGPL---TIS-----AQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDE 776
            ..:|.|   :|.:   |:|     ..||..:...|.....|.....|..:...|:..:..:...|
Yeast   903 DTTTKEATSRGNVHEDTVSKFVETTVENSNLNVNRVKDDEEKTERTESDVFDRDVPTLGSQSDSE 967

Human   777 SQTGEPGWLGGELKGKTGWFPANYAEKIPE------NEVPAP-VKPVTDSTSAPAPKLALRETPA 834
            :.....|...|.....     .|..|.:.:      ||...| .:.:|.|.:..||:....:...
Yeast   968 NANTNNGTQSGNETAN-----PNLTETLSDRFDGDLNEYGIPRSQSLTSSVANNAPQSVRDDVEL 1027

Human   835 PLAVTSSEPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATAT 899
            |   .:.|...|.||.|:..:|    .|.......|:|..|..|..|.|       :..|.....
Yeast  1028 P---ETLEERDTINNTANRDNT----GNLSHIPGEWEATPATASTDVLS-------NETTEVIED 1078

Human   900 GSSPSPVLG--QGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGWFP 962
            ||:......  .||.|..:|.......:.|..           |:.|:               ||
Yeast  1079 GSTTKRANSNEDGESVSSIQESPKISAQPKAK-----------TINEE---------------FP 1117

Human   963 KSYVKLISGPIRKSTSMDSGSSES------------PASLKRVASP-AAKPVVSGE---EFIAMY 1011
                     ||::....:|.||.|            .|::|.:.:| .|:|..|.|   |.:..|
Yeast  1118 ---------PIQELHIDESDSSSSDDDEFEDTREIPSATVKTLQTPYNAQPTSSLEIHTEQVIKY 1173

Human  1012 ----TYESSEQGDLTFQQGDVILVTKKD-GDWWTGTVGDKAGVFPSNYVRLKDSEGS----GTAG 1067
                |..|..:|:......:.||..|.: .|.:.|.  ::|.|...|..   |||..    ..||
Yeast  1174 PAPGTSPSHNEGNSKKASTNSILPVKDEFDDEFAGL--EQAAVEEDNGA---DSESEFENVANAG 1233

Human  1068 K---------------------TGSLGK-------KPEIAQVIASYTATGPEQLTLAPGQLILIR 1104
            .                     ||:|..       ||::.|           |.|..|.|:    
Yeast  1234 SMEQFETIDHKDLDDELQMNAFTGTLTSSSNPTIPKPQVQQ-----------QSTSDPAQV---- 1283

Human  1105 KKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQ 1169
               ....|:......|..:             :..|...||:.|.:...|              :
Yeast  1284 ---SNDEWDEIFAGFGNSK-------------AEPTKVATPSIPQQPIPL--------------K 1318

Human  1170 NDD--ELAFNKGQIIN 1183
            ||.  :.:.:||.|:|
Yeast  1319 NDPIVDASLSKGPIVN 1334

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ITSN1NP_003015.2 EH 14..108 CDD:197477 34/106 (32%)
EH 214..309 CDD:197477 32/103 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 322..348 9/88 (10%)
KLERQ 326..702 88/521 (17%)
Smc <363..>684 CDD:440809 76/423 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 650..701 9/56 (16%)
SH3_Intersectin1_1 744..803 CDD:212920 8/58 (14%)
INTAP 803..917 CDD:435467 27/122 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 836..868 7/31 (23%)
SH3_Intersectin1_2 917..968 CDD:212922 6/50 (12%)
SH3_Intersectin1_3 1006..1057 CDD:212924 13/55 (24%)
SH3_Intersectin1_4 1074..1138 CDD:212926 9/70 (13%)
Required for interaction with FCHSD2. /evidence=ECO:0000269|PubMed:29887380 1074..1138 9/70 (13%)
Bipartite nuclear localization signal, in isoform 2. /evidence=ECO:0000269|PubMed:29599122 1104..1127 2/22 (9%)
SH3_Intersectin1_5 1158..1211 CDD:212928 6/28 (21%)
RhoGEF 1238..1421 CDD:238091
PH_13 1440..1582 CDD:465218
C2_Intersectin 1582..1716 CDD:176021
EDE1NP_009506.1 EH 9..101 CDD:197477 32/101 (32%)
EH 128..221 CDD:197477 11/92 (12%)
EH 270..363 CDD:197477 30/92 (33%)
Smc <589..>879 CDD:440809 73/338 (22%)
COG4372 713..1052 CDD:443500 75/379 (20%)
UBA_scEDE1_like 1345..1379 CDD:270471
Blue background indicates that the domain is not in the aligned region.

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