Protein Alignment ITSN1 and itsn1

DIOPT Version :10

• Sequence 1: NP_003015.2
• Gene: ITSN1 / 6453
• HGNCID: 6183
• Length: 1721
• Species: Homo sapiens
• Sequence 2: XP_002939390.1
• Gene: itsn1 / 733480
• XenbaseID: XB-GENE-5904194
• Length: 1709
• Species: Xenopus tropicalis
• Alignment Length: 1727
• Identity: 1497/1727 - (86%)
• Similarity: 1586/1727 - (91%)
• Gaps: 24/1727 - (1%)

Human     1 MAQFPTPFGGSLDIWAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQIWALA 65
            ||||.|||||:|||||||||||||||||||.|:|.:|:||||||||||.||||||||||||||||
 Frog     1 MAQFGTPFGGNLDIWAITVEERAKHDQQFHGLQPTAGYITGDQARNFFLQSGLPQPVLAQIWALA 65

Human    66 DMNNDGRMDQVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPA------FGMGGIASMP 124
            ||||||||||:||||||||||||||||.||||||..|.:||||:|:|.|      |||.||:.:|
 Frog    66 DMNNDGRMDQLEFSIAMKLIKLKLQGYPLPSALPSNMLKQPVAMSAAAAAAAAAGFGMSGISGIP 130

Human   125 PLTAVAPVPMGSIPVVGMSPTLVSSVPTAAVPPLANGAPPVIQPLPAFAHPAATLPKSSSFSRSG 189
            ||.|||||||.|||||||||.|||||||  |||||||||.|||||||||| :|||||||||.|||
 Frog   131 PLAAVAPVPMPSIPVVGMSPPLVSSVPT--VPPLANGAPAVIQPLPAFAH-SATLPKSSSFGRSG 192

Human   190 PGSQLNTKLQKAQSFDVASVPPVAEWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSL 254
            .|||:||||||||||||.:.||:||||||||||||||||||||||||||||||||||||||||||
 Frog   193 AGSQMNTKLQKAQSFDVPTPPPLAEWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSL 257

Human   255 PQAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGISV 319
            ||:|||:||||||||.||||||||||||||||||||||||||||||||||||||||||||||:|:
 Frog   258 PQSQLATIWNLSDIDLDGKLTAEEFILAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGLSI 322

Human   320 ISSTSVDQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLA 384
            :||.||||||||||. |:|.|..:|:|||||||||||||||||||||||||||||||||||||||
 Frog   323 MSSVSVDQRLPEEPA-EEEPQNTDKRLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLA 386

Human   385 QLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEW 449
            |||||||||||||||:||||||.||||||||||||||||||||||||||||||||||||||||||
 Frog   387 QLERAEQERKERERQDQERKRQQELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEW 451

Human   450 ERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTN 514
            |||||||||||||:||||||||||||||||||||||||||||||||||||||||||||.||||||
 Frog   452 ERNRRQELLNQRNREQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRHEIESTN 516

Human   515 KSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELAR 579
            ||||||||||||||||||||||:||:||||||.||||||||||||||||||:||||||||||:.|
 Frog   517 KSRELRIAEITHLQQQLQESQQLLGKLIPEKQSLNDQLKQVQQNSLHRDSLLTLKRALEAKEMGR 581

Human   580 QHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEK 644
            |.|||||||||||||:||||||:||||||||||::|:|||||||..|||::||||.|||..||:|
 Frog   582 QQLRDQLDEVEKETRAKLQEIDVFNNQLKELRELYNRQQLQKQKDFEAEKIKQKELERKTSELDK 646

Human   645 QKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLF 709
            .|||.:||..|:||.|.:.|:||:|..   |..:|||.|||||.::  .||:.|.|.|:|..:||
 Frog   647 MKEEDKRRMLEQDKLWQDRVKQEEERY---KFQDEEKQKREESAQQ--CEEEKKPEIQEKPNKLF 706

Human   710 HQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWV 774
            |...||.|.....||...||.|||.: |.:||||||||||||::|||||||||||||:|     |
 Frog   707 HLPPEPGKLGGHVPWMNTEKAPLTFN-QGDVKVVYYRALYPFDARSHDEITIQPGDIIM-----V 765

Human   775 DESQTGEPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVT 839
            ||||||||||||||||||||||||||||::||.|.|:..|...|:|:.|...|| ..||.|.|.|
 Frog   766 DESQTGEPGWLGGELKGKTGWFPANYAERMPEGEFPSTTKQAADTTAKPTVHLA-PSTPTPAAFT 829

Human   840 SSEPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPS 904
            .:  |...||||||||||||:..:|.||||||.|.||||||||||||.||||||||||.||||||
 Frog   830 DN--SANSNNWADFSSTWPTNNTDKAETDNWDTWGAQPSLTVPSAGQHRQRSAFTPATVTGSSPS 892

Human   905 PVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGWFPKSYVKLI 969
            ||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||
 Frog   893 PVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDIITVLEQQDMWWFGEVQGQKGWFPKSYVKLI 957

Human   970 SGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKK 1034
            |||:|||||:||.|||||||||||:|||.||.:.|||:||||||||:|||||||||||:|:|.||
 Frog   958 SGPLRKSTSIDSTSSESPASLKRVSSPAFKPAMQGEEYIAMYTYESNEQGDLTFQQGDLIVVIKK 1022

Human  1035 DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQ 1099
            ||||||||||:|.|||||||||.||||.:|:||||||||||||||||||||||||||||||||||
 Frog  1023 DGDWWTGTVGEKTGVFPSNYVRPKDSEAAGSAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQ 1087

Human  1100 LILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMY 1164
            |||||||||||||||||||||||||||||||||||||||||:|.|||||||:|:|...|||||||
 Frog  1088 LILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTNKSTPTEPPKATSLPPTCQVIGMY 1152

Human  1165 DYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQQWCSDLHLLD 1229
            ||.|||||||||.|||:|||||||||||||||:||.||||||||||||||||||||||:||||||
 Frog  1153 DYIAQNDDELAFGKGQVINVLNKEDPDWWKGELNGHVGLFPSNYVKLTTDMDPSQQWCADLHLLD 1217

Human  1230 MLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKELIMCNIK 1294
            ||:|||||||||||||||||||||||||||||.|||||:||||||||||||||||||||||||||
 Frog  1218 MLSPTERKRQGYIHELIVTEENYVNDLQLVTETFQKPLLESELLTEKEVAMIFVNWKELIMCNIK 1282

Human  1295 LLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFCSRQLNGAALIQQKTDEAPDFKEFVKR 1359
            |||||||||||||||||||||||||:||||||||||||||.||||||||||||||.|:|||||||
 Frog  1283 LLKALRVRKKMSGEKMPVKMIGDILTAQLPHMQPYIRFCSCQLNGAALIQQKTDEVPEFKEFVKR 1347

Human  1360 LAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSHLKHALEKAEELCSQVNEGV 1424
            |||||||||||||||:|||||||||||||||||:||||||||||||||.||||||||||||||||
 Frog  1348 LAMDPRCKGMPLSSFLLKPMQRVTRYPLIIKNIIENTPENHPDHSHLKQALEKAEELCSQVNEGV 1412

Human  1425 REKENSDRLEWIQAHVQCEGLSEQLVFNSVTNCLGPRKFLHSGKLYKAKSNKELYGFLFNDFLLL 1489
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog  1413 REKENSDRLEWIQAHVQCEGLSEQLVFNSVTNCLGPRKFLHSGKLYKAKSNKELYGFLFNDFLLL 1477

Human  1490 TQITKPLGSSGTDKVFSPKSNLQYKMYKTPIFLNEVLVKLPTDPSGDEPIFHISHIDRVYTLRAE 1554
            |||.|||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog  1478 TQIIKPLGSSGNDKVFSPKSNLQYKMYKTPIFLNEVLVKLPTDPSGDEPIFHISHIDRVYTLRAE 1542

Human  1555 SINERTAWVQKIKAASELYIETEKKKREKAYLVRSQRATGIGRLMVNVVEGIELKPCRSHGKSNP 1619
            |||||||||||||||||||||||||||||||||||||||||||||||:||||||||||:||||||
 Frog  1543 SINERTAWVQKIKAASELYIETEKKKREKAYLVRSQRATGIGRLMVNIVEGIELKPCRTHGKSNP 1607

Human  1620 YCEVTMGSQCHITKTIQDTLNPKWNSNCQFFIRDLEQEVLCITVFERDQFSPDDFLGRTEIRVAD 1684
            |||:||||||||||||||||||||||||||||:||||:|||||||||||||||||||||||||||
 Frog  1608 YCEITMGSQCHITKTIQDTLNPKWNSNCQFFIKDLEQDVLCITVFERDQFSPDDFLGRTEIRVAD 1672

Human  1685 IKKDQGSKGPVTKCLLLHEVPTGEIVVRLDLQLFDEP 1721
            |||||||||||||||||||||||||||||||||||||
 Frog  1673 IKKDQGSKGPVTKCLLLHEVPTGEIVVRLDLQLFDEP 1709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ITSN1	NP_003015.2	EH	14..108	CDD:197477	81/93 (87%)
		EH	214..309	CDD:197477	91/94 (97%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	322..348		16/25 (64%)
		KLERQ	326..702		313/375 (83%)
		Smc	<363..>684	CDD:440809	275/320 (86%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	650..701		22/50 (44%)
		SH3_Intersectin1_1	744..803	CDD:212920	50/58 (86%)
		INTAP	803..917	CDD:435467	75/113 (66%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	836..868		17/31 (55%)
		SH3_Intersectin1_2	917..968	CDD:212922	49/50 (98%)
		SH3_Intersectin1_3	1006..1057	CDD:212924	43/50 (86%)
		SH3_Intersectin1_4	1074..1138	CDD:212926	63/63 (100%)
		Required for interaction with FCHSD2. /evidence=ECO:0000269|PubMed:29887380	1074..1138		63/63 (100%)
		Bipartite nuclear localization signal, in isoform 2. /evidence=ECO:0000269|PubMed:29599122	1104..1127		22/22 (100%)
		SH3_Intersectin1_5	1158..1211	CDD:212928	47/52 (90%)
		RhoGEF	1238..1421	CDD:238091	173/182 (95%)
		PH_13	1440..1582	CDD:465218	139/141 (99%)
		C2_Intersectin	1582..1716	CDD:176021	128/133 (96%)
itsn1	XP_002939390.1	EH	14..108	CDD:197477	81/93 (87%)
		EH	217..312	CDD:197477	91/94 (97%)
		PTZ00121	<354..701	CDD:173412	296/351 (84%)
		SH3_Intersectin1_1	740..794	CDD:212920	50/58 (86%)
		INTAP	794..905	CDD:435467	75/113 (66%)
		SH3_Intersectin1_2	905..956	CDD:212922	49/50 (98%)
		SH3_Intersectin1_3	994..1045	CDD:212924	43/50 (86%)
		SH3_Intersectin1_4	1062..1126	CDD:212926	63/63 (100%)
		SH3_Intersectin1_5	1146..1199	CDD:212928	47/52 (90%)
		RhoGEF	1226..1409	CDD:238091	173/182 (95%)
		PH_13	1428..1570	CDD:465218	139/141 (99%)
		C2_Intersectin	1570..1704	CDD:176021	128/133 (96%)