DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ITSN1 and Dap160

DIOPT Version :10

Sequence 1:NP_003015.2 Gene:ITSN1 / 6453 HGNCID:6183 Length:1721 Species:Homo sapiens
Sequence 2:NP_001246118.1 Gene:Dap160 / 35378 FlyBaseID:FBgn0023388 Length:1190 Species:Drosophila melanogaster


Alignment Length:1485 Identity:441/1485 - (29%)
Similarity:659/1485 - (44%) Gaps:469/1485 - (31%)


- Green bases have known domain annotations that are detailed below.


Human    11 SLDIWAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQIWALADMNNDGRMDQ 75
            ::|.||:|..||.|:.:||.:|:|.:||:||.||:.||.||.||..:|.|||||||.::||:|:.
  Fly     4 AVDAWAVTPRERLKYQEQFRALQPQAGFVTGAQAKGFFLQSQLPPLILGQIWALADTDSDGKMNI 68

Human    76 VEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPAFGMGGIASMPP---LTAVAPVPMGSI 137
            .|||||.|||.|||:|..:|..|||.:      :||.    .|.:.||.|   .::::|:.    
  Fly    69 NEFSIACKLINLKLRGMDVPKVLPPSL------LSSL----TGDVPSMTPRGSTSSLSPLD---- 119

Human   138 PVVGMSPTLVSSVPTAAVPPLANGAPPVIQPLPAFAHPAATLPKSSSFSRSGPGSQLNTKLQKAQ 202
            |:.|:.|.:...||..| ||:|  ...||.|      |..::|...:...|.|.|:..:..::|.
  Fly   120 PLKGIVPAVAPVVPVVA-PPVA--VATVISP------PGVSVPSGPTPPTSNPPSRHTSISERAP 175

Human   203 SFDVASVPPVAEWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSD 267
            |.:..:   ..||||..:.:.||.|:||::|:|.||:|||.|||.:|:||.|||..||.||.|||
  Fly   176 SIESVN---QGEWAVQAAQKRKYTQVFNANDRTRSGYLTGSQARGVLVQSKLPQVTLAQIWTLSD 237

Human   268 IDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGISVISSTSVDQRLPEE 332
            ||.||:|..:||||||.|.:.||:|:.:|..||.|::||:.|:::|..|    |.:.|..|...:
  Fly   238 IDGDGRLNCDEFILAMFLCEKAMAGEKIPVTLPQEWVPPNLRKIKSRPG----SVSGVVSRPGSQ 298

Human   333 PVLEDEQQQLEKKLPVTFED---------KKRENFERGNLELEKRRQALLEQQRKEQERLAQLER 388
            |.........:..:.|...|         |::||:.:|..||::||:.:.:|||||:|...:.||
  Fly   299 PASRHASVSSQSGVGVVDADPTAGLPGQNKRKENYVKGQAELDRRRKIMEDQQRKEREERERKER 363

Human   389 AEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNR 453
            .|.:::|:.|.|.|||:|.|||:||::|||:|.::||:|::|:|.:|||::|||:|||.|||:.|
  Fly   364 EEADKREKARLEAERKQQEELERQLQRQREIEMEKEEQRKRELEAKEAARKELEKQRQQEWEQAR 428

Human   454 RQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRE 518
            ..|:..|:.:|||.::..||....|..||..||:|..:|..::.|.|..:|..:..|:.....|:
  Fly   429 IAEMNAQKEREQERVLKQKAHNTQLNVELSTLNEKIKELSQRICDTRAGVTNVKTVIDGMRTQRD 493

Human   519 LRIAEITHLQQQLQESQQMLGRLIPEK-----------QILNDQLKQVQQNSLHRDSLVTLKRAL 572
            ..::|::.|:.:::|....|.:|..|:           ..|..:..|.:|          |..|.
  Fly   494 TSMSEMSQLKARIKEQNAKLLQLTQERAKWEAKSKASGAALGGENAQQEQ----------LNAAF 548

Human   573 EAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQER 637
            ..|:|....::|:::.:.||..||.::|:..:.|:.||:             .|...|..|    
  Fly   549 AHKQLIINQIKDKVENISKEIESKKEDINTNDVQMSELK-------------AELSALITK---- 596

Human   638 KIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQ 702
                                   .|.:.:|.:.||...|..:...|.|.||  ....:.|...|.
  Fly   597 -----------------------CEDLYKEYDVQRTSVLELKYNRKNETSV--SSAWDTGSSSAW 636

Human   703 DKLGRLFHQHQEPAKPAVQAPWSTAEK-------------GPLTISAQENVKVVYYRALYPFESR 754
            ::.|           ..|..|::.|..             ||    |.|.  .|.|:|:|.|.:|
  Fly   637 EETG-----------TTVTDPYAVASNDISALAAPAVDLGGP----APEG--FVKYQAVYEFNAR 684

Human   755 SHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTDS 819
            :.:|||..||||::|..|     |..|||||.||:.|.|||||.:|.||:...|| |||..|   
  Fly   685 NAEEITFVPGDIILVPLE-----QNAEPGWLAGEINGHTGWFPESYVEKLEVGEV-APVAAV--- 740

Human   820 TSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSA 884
                       |.|....|            |..:.|:..:.|               :.::|:|
  Fly   741 -----------EAPVDAQV------------ATVADTYNDNIN---------------TSSIPAA 767

Human   885 GQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMW 949
            .        ...||.|                                     ||          
  Fly   768 S--------ADLTAAG-------------------------------------DV---------- 777

Human   950 WFGEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYE 1014
                                                                   |.:||.|.||
  Fly   778 -------------------------------------------------------EYYIAAYPYE 787

Human  1015 SSEQGDLTFQQGDVILVTKKDGDWWTGTVGDKAGVFPSNYVRLKD-------------------- 1059
            |:|:|||:|..|::::|.||:|:|||||:|.:.|:||||||:..|                    
  Fly   788 SAEEGDLSFSAGEMVMVIKKEGEWWTGTIGSRTGMFPSNYVQKADVGTASTAAAEPVESLDQETT 852

Human  1060 ---------------------------------SEGSG----------------TAGKT------ 1069
                                             |.|.|                |..||      
  Fly   853 LNGNAAYTAAPVEAQEQVYQPLPVQEPSEQPISSPGVGAEEAHEDLDTEVSQINTQSKTQSSEPA 917

Human  1070 ---------------GSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQAR 1119
                           |...|:.|||||||.|.||..|||:|..||||:||||...|||||||||:
  Fly   918 ESYSRPMSRTSSMTPGMRAKRSEIAQVIAPYEATSTEQLSLTRGQLIMIRKKTDSGWWEGELQAK 982

Human  1120 GKKRQIGWFPANYVKLLSPG--TSKITPTEPPKSTALAAVC-QVIGMYDYTAQNDDELAFNKGQI 1181
            |::||||||||.|||:|..|  :.:.||....:......:. :||.:|.|.|||||||:|:|..|
  Fly   983 GRRRQIGWFPATYVKVLQGGRNSGRNTPVSGSRIEMTEQILDKVIALYPYKAQNDDELSFDKDDI 1047

Human  1182 INVLNKEDPDWWKGEVNGQVGLFPSNYVK--LTTDMDPSQQWCSDLHLLDMLTPTERKRQGYIHE 1244
            |:||.:::|:||:||:||..||||||||.  :|:::.|....||            |:.:| |..
  Fly  1048 ISVLGRDEPEWWRGELNGLSGLFPSNYVGPFVTSEIKPDPGACS------------RRSKG-IQR 1099

Human  1245 LIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKELIMCNIK--------------- 1294
            |                                       |::...|:|.               
  Fly  1100 L---------------------------------------WQQWRGCDIDQAAQHGDASNNKLRG 1125

Human  1295 LLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFCSRQLNGAALIQQKTDE 1349
            :::|:.:.|:..|:.|..               .|:||...:|...:::|:..::
  Fly  1126 IIQAVHITKRRDGQLMGC---------------AYVRFECNELLAKSMLQENGNQ 1165

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ITSN1NP_003015.2 EH 14..108 CDD:197477 49/93 (53%)
EH 214..309 CDD:197477 53/94 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 322..348 3/25 (12%)
KLERQ 326..702 109/395 (28%)
Smc <363..>684 CDD:440809 96/331 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 650..701 10/50 (20%)
SH3_Intersectin1_1 744..803 CDD:212920 29/58 (50%)
INTAP 803..917 CDD:435467 18/113 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 836..868 4/31 (13%)
SH3_Intersectin1_2 917..968 CDD:212922 2/50 (4%)
SH3_Intersectin1_3 1006..1057 CDD:212924 29/50 (58%)
SH3_Intersectin1_4 1074..1138 CDD:212926 45/63 (71%)
Required for interaction with FCHSD2. /evidence=ECO:0000269|PubMed:29887380 1074..1138 45/63 (71%)
Bipartite nuclear localization signal, in isoform 2. /evidence=ECO:0000269|PubMed:29599122 1104..1127 16/22 (73%)
SH3_Intersectin1_5 1158..1211 CDD:212928 32/55 (58%)
RhoGEF 1238..1421 CDD:238091 15/127 (12%)
PH_13 1440..1582 CDD:465218
C2_Intersectin 1582..1716 CDD:176021
Dap160NP_001246118.1 EH 7..101 CDD:197477 51/103 (50%)
EH 184..279 CDD:197477 53/94 (56%)
SMC_prok_B <368..>615 CDD:274008 83/296 (28%)
SH3_Intersectin_1 674..728 CDD:212770 29/58 (50%)
SH3_Intersectin_3 779..830 CDD:212772 29/50 (58%)
SH3_Intersectin_4 941..998 CDD:212773 41/56 (73%)
SH3_Intersectin_5 1025..1077 CDD:212774 32/51 (63%)
RRM_SF <1125..1175 CDD:473069 9/56 (16%)
Blue background indicates that the domain is not in the aligned region.

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