DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ITSN1 and itsn-1

DIOPT Version :10

Sequence 1:NP_003015.2 Gene:ITSN1 / 6453 HGNCID:6183 Length:1721 Species:Homo sapiens
Sequence 2:NP_001299978.1 Gene:itsn-1 / 178491 WormBaseID:WBGene00006405 Length:1087 Species:Caenorhabditis elegans


Alignment Length:1257 Identity:379/1257 - (30%)
Similarity:574/1257 - (45%) Gaps:237/1257 - (18%)


- Green bases have known domain annotations that are detailed below.


Human    15 WAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQIWALADMNNDGRMDQVEFS 79
            |.::..|..|:...|..|.....|:....|||...:|.||..||:|||||:|::.|||:|..|:|
 Worm     5 WEVSDAEYQKNFAMFGQLTGGQPFMDAVTARNALMRSNLPTQVLSQIWALSDLDKDGRLDIREYS 69

Human    80 IAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPAFGMGGIASMPPLTAVAPVPMGSIPVVGMSP 144
            |||:|....|.|..:|..|||                           ::..||..:.|     |
 Worm    70 IAMRLALNCLAGIPIPPQLPP---------------------------SLLVVPARNAP-----P 102

Human   145 TLVSSVPTAAVPPLANGAPPVIQPLPAFAHPAATLPKSSSFSRSGPGSQLNTKLQKAQSFDVASV 209
            |.         |...:|:....|.||    ||.....|.|:..|.|.|...|...:..|....| 
 Worm   103 TW---------PGSRHGSVDYSQTLP----PAIDRRMSQSYIPSAPVSIAGTPSSRHNSISAGS- 153

Human   210 P-----------PVAEWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIW 263
            |           .:..||:|..::|||.||||:.||...|.|:....|:.|..|.||...||.||
 Worm   154 PLNNDRNVFEGRQLENWAIPHHNKLKYSQLFNALDKERLGSLSSQVGRSALGLSGLPTNVLAHIW 218

Human   264 NLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGISVISSTSVDQR 328
            .|||:::||||:.:|:.::.::|::..||..||.:.|.|.:           .:..|||.|.:..
 Worm   219 FLSDVNKDGKLSVDEYAISQYMIEMFKSGFALPKITPLELV-----------RMCGISSRSANNT 272

Human   329 LPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQER 393
            ...||..|..|   :...|.|||||:::|..:|..|||:||:.|.|::::.:..:.:.||.|:.:
 Worm   273 PELEPGAEPPQ---KSPAPKTFEDKRQDNLSKGQAELERRRRVLEEEEQRRRAEVEKKEREEEAK 334

Human   394 KERERQEQERKRQLELEKQLEKQRELERQREEE---RRKEIERREAAKRELERQRQLEWERNRRQ 455
            |.|||||:||:.::|.:.:||:||.:|.|||||   ||.|:|||   :.|.|:.|:::.|:.:.:
 Worm   335 KNRERQEKERQAEVERQAELERQRIIEAQREEEEKKRRLEMERR---REEDEKMRKVQMEKAKVK 396

Human   456 ELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLE---GKLQDIRCRLTTQRQEIESTNKSR 517
            ::.||:.:|.|.:...:.::|||:|:|:||::|...:|   ||.::....:|...:.:.||   |
 Worm   397 QMQNQKQQENERLAQRQQREKTLQFQLQALDEKVIDVEVDIGKAKEAVAEVTGFIERMRST---R 458

Human   518 ELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHL 582
            :.::|.|..||:..|:.|..:     |.|.|..||  :|:.|.|::: ...|..|||....|..:
 Worm   459 DEKVARIKELQETNQKFQTAI-----ESQELGHQL--LQKQSAHKET-TQRKSELEALRRKRDAI 515

Human   583 RDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKE 647
            |..:::...|..::.::   ..||.:.|:....|.:......:.|:|    |:.|...||     
 Worm   516 RKAIEDAALELSTEKEK---SYNQTEILKTNKEKYKTDVYSKLVAKR----EEYRNSFEL----- 568

Human   648 EAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGE------------------ 694
                         |.|.|   .|.| .|:.|.|......|.......                  
 Worm   569 -------------LVHAQ---THAR-SKIGEFEAKSAPASAAPAPAPAPAPTTTNGFPANFNDAF 616

Human   695 -EKGKQEAQDKLGRLF--HQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVY-YRALYPFESRS 755
             |..|.:|..:....|  ....:|.....|||  ...||.:..|| .|:...| .|||:.||:||
 Worm   617 GEFDKTDASQRFDADFGATSTADPFAQIAQAP--AHSKGAVDQSA-FNIHDTYKCRALFAFEARS 678

Human   756 HDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTDST 820
            .||::.:|||:::     |.:|...||||..|:|:.|.||||..:.|.|.  .||.|        
 Worm   679 EDELSFEPGDVII-----VFQSHAAEPGWRAGQLREKVGWFPEAFVEAIA--AVPTP-------- 728

Human   821 SAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAG 885
            ....|            :.:..|:.||::..|...   .....|.|.      ||...||...| 
 Worm   729 GGDPP------------IQNMPPNMTPSSSVDQIG---VKAARKAEI------AAAMGLTEGGA- 771

Human   886 QLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWW 950
                     |..::..:.:.|:.        |..|.:.|||:.:..|:|.|.|.|.|||:|:|.|
 Worm   772 ---------PPASSAPAAAAVIS--------QCIAQFQWRARNEEDLSFAKGDTIEVLEKQEMKW 819

Human   951 FG-EVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEE-------- 1006
            .| ...|:.|||||||||.:......:|.:.|.|..| |.....|:.|...||..:.        
 Worm   820 KGRNPAGEIGWFPKSYVKEVGATTSTTTPIVSPSKAS-AGAPGAAAGAQYDVVPSDVTLQASETA 883

Human  1007 -----FIAMYTYESSEQGDLTFQQGDVILVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTA 1066
                 :..:|.:|:.|..||....||.|||.:|:.:||.|....:.|:||:|||.:...:.....
 Worm   884 PQQQLYTVIYDFEAVETTDLALHVGDTILVLEKNDEWWKGRCNGREGIFPANYVEISVQQAGDPT 948

Human  1067 GKT--GSLGKKPEI---AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIG 1126
            ..|  .:....|.:   |:|:..:.|:.|.||.:..|:::.||:|:..|||||||...||. ..|
 Worm   949 PPTQAPTPAAPPTVLCEAKVVVDFVASAPNQLGIKVGEIVKIREKSAAGWWEGELIRNGKP-IAG 1012

Human  1127 WFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPD 1191
            |||..|||:|....|..|     ::||         :|||.|...|||.|..|.:|.|.:|.:.:
 Worm  1013 WFPGEYVKVLEEAASPAT-----RATA---------VYDYEASQPDELGFKTGDVIIVTDKSEAE 1063

Human  1192 WWKG---EVNGQVGLFPSNYVK 1210
            ||.|   :...:.||||||||:
 Worm  1064 WWSGHREQDPSKSGLFPSNYVQ 1085

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ITSN1NP_003015.2 EH 14..108 CDD:197477 36/92 (39%)
EH 214..309 CDD:197477 38/94 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 322..348 6/25 (24%)
KLERQ 326..702 112/400 (28%)
Smc <363..>684 CDD:440809 97/326 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 650..701 11/69 (16%)
SH3_Intersectin1_1 744..803 CDD:212920 26/59 (44%)
INTAP 803..917 CDD:435467 18/113 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 836..868 6/31 (19%)
SH3_Intersectin1_2 917..968 CDD:212922 26/51 (51%)
SH3_Intersectin1_3 1006..1057 CDD:212924 20/63 (32%)
SH3_Intersectin1_4 1074..1138 CDD:212926 28/66 (42%)
Required for interaction with FCHSD2. /evidence=ECO:0000269|PubMed:29887380 1074..1138 28/66 (42%)
Bipartite nuclear localization signal, in isoform 2. /evidence=ECO:0000269|PubMed:29599122 1104..1127 11/22 (50%)
SH3_Intersectin1_5 1158..1211 CDD:212928 23/56 (41%)
RhoGEF 1238..1421 CDD:238091
PH_13 1440..1582 CDD:465218
C2_Intersectin 1582..1716 CDD:176021
itsn-1NP_001299978.1 EH 4..93 CDD:197477 36/114 (32%)
EH 169..259 CDD:197477 38/89 (43%)
Smc <337..>548 CDD:440809 72/227 (32%)
SH3_Intersectin_1 667..721 CDD:212770 25/58 (43%)
SH3_Intersectin_2 786..838 CDD:212771 26/51 (51%)
SH3 889..938 CDD:214620 19/48 (40%)
SH3_Intersectin_4 965..1021 CDD:212773 25/56 (45%)
SH3 1028..1085 CDD:214620 25/70 (36%)
Blue background indicates that the domain is not in the aligned region.

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