DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CPEB1 and orb

DIOPT Version :9

Sequence 1:NP_001373990.1 Gene:CPEB1 / 64506 HGNCID:21744 Length:593 Species:Homo sapiens
Sequence 2:NP_001262870.1 Gene:orb / 42752 FlyBaseID:FBgn0004882 Length:915 Species:Drosophila melanogaster


Alignment Length:728 Identity:248/728 - (34%)
Similarity:346/728 - (47%) Gaps:220/728 - (30%)


- Green bases have known domain annotations that are detailed below.


Human     6 ATSTSSSMSGTGLEHSSLSDCLLLIPLEEEAGRIKDCWDNQEAPALS------------------ 52
            |.:.|:|..|.|    |.||...|:.....|.......|..:..|.:                  
  Fly   171 AANPSASFGGNG----SSSDVNNLLLASAAAAAAAAAGDGAQLSANAAAYAPLTPSSTHSSASPG 231

Human    53 TCSNANIFRRINAILDNSLD-FSRV-----CTTPI---------NRGIHDHLPDFQDSEETVTSR 102
            |.||.:.|:..|....|.|. |.|.     |:.|:         ||..|.. |...||       
  Fly   232 TKSNFDYFQFENVAQSNPLKAFQRTNISFDCSAPLSPSTPTSIYNRSFHSS-PLVSDS------- 288

Human   103 MLFPTSAQESSRGLPDANDLCLGLQSLSLTGWDRPWSTQDSDSSAQSSTHSVLSMLHNPLGNVLG 167
                   ..||.|:.      |.:.|:::. :::....|..:....:|           |||.:|
  Fly   289 -------SNSSSGIG------LSMDSINMF-YNQQQQQQQPEQQGYTS-----------LGNSMG 328

Human   168 KPPLSFLPLDPLGSDLVDKFPAPSVRGSRLDTRPILDSRSSSPSDSDTSGFSSGSDHLSDLISSL 232
                     ..||..|.:                 ..:||:|| :|..|..|:...:|.|:|:.|
  Fly   329 ---------SGLGLSLAN-----------------ASTRSNSP-ESQNSSNSTTEQNLLDMINLL 366

Human   233 RI-SPPLP-----------------------------------FLSLSG----------GGPRDP 251
            .: |..:|                                   |::|:.          |..:..
  Fly   367 SVNSNKIPHQQQQQQQQQQQQQQQQQQNQQQLQVQQQHQLQQQFVNLNRNYEQQISANLGSQQHG 431

Human   252 LK---MGVG------------------SRMDQEQAAL---------------AAVTPSPTSASKR 280
            .:   :|||                  :.:|.|.|.|               |...|......:.
  Fly   432 FEHNGVGVGASSSGNENCFSQYNLENITSVDMELAKLQNLQRINTLKLLHAQAQQMPLINQLLQS 496

Human   281 WPG---ASVWPS--WDLLEA-----------------PKDPFSIEREARLHRQAAAVNEATCTWS 323
            :.|   .||..|  .:|:.|                 ..:...::|.|:.::.:||:.:||||||
  Fly   497 YAGNAIGSVGGSNLGNLMSAGGSSLMTEMAGNVGGIITTNDGHLDRVAKFYKSSAALCDATCTWS 561

Human   324 GQLPPRNYKNPIYSCKVFLGGVPWDITEAGLVNTFRVFGSLSVEWPGKDGKHPRCPPKGNMPKGY 388
            |.||||:::...||.||||||:||||:|..|:..|:.|||:.||||||:       .:...||||
  Fly   562 GHLPPRSHRMLNYSPKVFLGGIPWDISEQSLIQIFKPFGSIKVEWPGKE-------QQAAQPKGY 619

Human   389 VYLVFELEKSVRSLLQAC------SHDPLSPDGLSEYYFKMSSRRMRCKEVQVIPWVLADSNFVR 447
            ||::||.:|.|::||.||      ||..      ..|:||:||||::.|:|:||||::|||||||
  Fly   620 VYIIFESDKQVKALLSACVLQVDDSHCG------RNYFFKISSRRIKSKDVEVIPWIIADSNFVR 678

Human   448 SPSQRLDPSRTVFVGALHGMLNAEALAAILNDLFGGVVYAGIDTDKHKYPIGSGRVTFNNQRSYL 512
            |.||:|||::|||||||||.|.||.|..|::|||.||:||||||||:|||||||||||:|.|||:
  Fly   679 SSSQKLDPTKTVFVGALHGKLTAEGLGNIMDDLFDGVLYAGIDTDKYKYPIGSGRVTFSNFRSYM 743

Human   513 KAVSAAFVEIKTTKFTKKVQIDPYLEDSLCHICSSQPGPFFCRDQVCFKYFCRSCWHWRHSMEGL 577
            |||||||:||:|||||||||:||||||:||.||..|.||::||:..||:|||||||.|:||.:.:
  Fly   744 KAVSAAFIEIRTTKFTKKVQVDPYLEDALCSICGVQHGPYYCRELSCFRYFCRSCWQWQHSCDIV 808

Human   578 RHHSPLMRNQKNR 590
            ::|.||.||.|::
  Fly   809 KNHKPLTRNSKSQ 821

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CPEB1NP_001373990.1 CEBP1_N 31..334 CDD:406706 80/439 (18%)
RRM1_CPEB1 336..443 CDD:410122 54/112 (48%)
RRM2_CPEB1 454..537 CDD:410124 64/82 (78%)
CEBP_ZZ 531..586 CDD:406704 32/54 (59%)
orbNP_001262870.1 CEBP1_N <540..570 CDD:292978 15/29 (52%)
RRM1_CPEB1 574..674 CDD:241167 54/112 (48%)
RRM2_CPEB1 685..770 CDD:241169 66/84 (79%)
CEBP_ZZ 762..817 CDD:292976 32/54 (59%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158366
Domainoid 1 1.000 149 1.000 Domainoid score I4436
eggNOG 1 0.900 - - E1_KOG0129
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0005701
OrthoInspector 1 1.000 - - oto91491
orthoMCL 1 0.900 - - OOG6_107196
Panther 1 1.100 - - LDO PTHR12566
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5171
SonicParanoid 1 1.000 - - X4096
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
109.770

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