Protein Alignment SGK1 and S6k

DIOPT Version :9

• Sequence 1: NP_001137148.1
• Gene: SGK1 / 6446
• HGNCID: 10810
• Length: 526
• Species: Homo sapiens
• Sequence 2: NP_001261450.1
• Gene: S6k / 38654
• FlyBaseID: FBgn0283472
• Length: 490
• Species: Drosophila melanogaster
• Alignment Length: 387
• Identity: 164/387 - (42%)
• Similarity: 230/387 - (59%)
• Gaps: 48/387 - (12%)

Human   160 EPELM------------------NANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGK 206
            ||||.                  |.||.       :|.||        |.||...||:|||.:||
  Fly    41 EPELCINLHQDTEGQETIQLCEENVNPG-------KIKLG--------PKDFELKKVLGKGGYGK 90

Human   207 VLLARHKA---EEVFYAVKVLQKKAIL-KKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKL 267
            |...|..|   ...::|:|||:|.:|: .:|:..|..:|||: |:.|||||:|.|.::|||..||
  Fly    91 VFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNI-LEAVKHPFIVELVYAFQTDGKL 154

Human   268 YFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIV 332
            |.:|:|::|||||.||:||..|||....||.:||..|||:||.|.|:||||||||||||:|||:.
  Fly   155 YLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLGIIYRDLKPENILLDAQGHVK 219

Human   333 LTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNT 397
            |||||||||:|:....|.|||||.||:|||:|.:..:.:.||||.|||::::||.|:|||.:.|.
  Fly   220 LTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMFDMLTGVPPFTAENR 284

Human   398 AEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINK 461
            .:..:.||...|.|...:|..||.|:..|:::...:|||: .:|...::.|.||..:||||::.:
  Fly   285 KKTIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQIHPFFKHVNWDDVLAR 349

Human   462 KITPPFNPNVSGPNDLRHFDPEFTEE-PVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPT 522
            ::.||..|.:...:|:..||..||.: ||     .|||...::.|   |...|.||:|..|:
  Fly   350 RLEPPIKPLLRSEDDVSQFDTRFTRQIPV-----DSPDDTTLSES---ANLIFQGFTYVAPS 403

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SGK1	NP_001137148.1	S_TKc	193..450	CDD:214567	126/261 (48%)
		STKc_SGK	197..519	CDD:270727	149/327 (46%)
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	149/329 (45%)
		STKc_p70S6K	81..402	CDD:270736	150/329 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0598
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740