DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SGK1 and gad8

DIOPT Version :9

Sequence 1:	NP_001137148.1	Gene:	SGK1 / 6446	HGNCID:	10810	Length:	526	Species:	Homo sapiens
Sequence 2:	NP_588010.1	Gene:	gad8 / 2539206	PomBaseID:	SPCC24B10.07	Length:	569	Species:	Schizosaccharomyces pombe

Alignment Length:	331	Identity:	170/331 - (51%)
Similarity:	211/331 - (63%)	Gaps:	10/331 - (3%)

- Green bases have known domain annotations that are detailed below.

Human   193 FHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGL 257
            |..|||:||||||||:..|.:.....||:|.::|..|:.:.|..|.::||.||.: |.:||:|.|
pombe   230 FELLKVVGKGSFGKVMQVRKRDTSRIYALKTMKKAHIVSRSEVDHTLAERTVLAQ-VNNPFIVPL 293

Human   258 HFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPEN 322
            .||||:..|||.||.::||||||:|||||.||...||:||.||:..||..||..|::||||||||
pombe   294 KFSFQSPGKLYLVLAFVNGGELFHHLQREGCFDTYRAKFYIAELLVALECLHEFNVIYRDLKPEN 358

Human   323 ILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLY 387
            ||||..|||.|.||||||.|:.....|:||||||||||||:|....|.:.||||.||.:||||:.
pombe   359 ILLDYTGHIALCDFGLCKLNMAKTDRTNTFCGTPEYLAPELLLGHGYTKVVDWWTLGVLLYEMIT 423

Human   388 GLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSL 452
            ||||||..|..|||..||..||:...||...|:.||.|||.:...||||: ....|||:|.||..
pombe   424 GLPPFYDENINEMYRKILQDPLRFPDNIDEKAKDLLSGLLTRAPEKRLGS-GGAQEIKNHPFFDD 487

Human   453 INWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAA-EAFLGF 516
            |:|..|..|||.|||.|:|....|..:||.|||.| :|      .|||:..:.:.|.. :.|..:
pombe   488 IDWKKLCAKKIQPPFKPSVESAIDTSNFDSEFTSE-IP------MDSVVADSHLSETVQQRFANW 545

Human   517 SYAPPT 522
            ||..||
pombe   546 SYQRPT 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SGK1	NP_001137148.1	S_TKc	193..450	CDD:214567	140/256 (55%)
SGK1	NP_001137148.1	STKc_SGK	197..519	CDD:270727	165/322 (51%)
gad8	NP_588010.1	YPK1_N_like	66..225	CDD:212165
		PTZ00263	214..545	CDD:140289	166/323 (51%)
		STKc_YPK1_like	235..547	CDD:270737	163/320 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	280	1.000	Domainoid score	I359
eggNOG	1	0.900	-	-		E1_KOG0598
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001348
OrthoInspector	1	1.000	-	-		mtm10296
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	1	1.000	-	-		X760
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.700