Protein Alignment DNAI2 and dic1

DIOPT Version :10

• Sequence 1: NP_001340096.1
• Gene: DNAI2 / 64446
• HGNCID: 18744
• Length: 649
• Species: Homo sapiens
• Sequence 2: NP_001342791.1
• Gene: dic1 / 5802757
• PomBaseID: SPBC646.17C
• Length: 544
• Species: Schizosaccharomyces pombe
• Alignment Length: 435
• Identity: 105/435 - (24%)
• Similarity: 167/435 - (38%)
• Gaps: 79/435 - (18%)

Human    86 NPLELEQTIRFRKKVEKDENYVNAIMQLGSIMEHCIKQNNAID--IYEEYFNDEEAMEVMEEDPS 148
            |.|..:.|::.:.|..|.:...|.:..|.:..:..|..|:.::  .|..:|  ||.:
pombe   154 NQLFTDYTVKKKSKKNKSQLEENGLNHLFTFQDEKITLNSVVNSISYSSFF--EELL-------- 208

Human   149 AKTINVFRDPQEIKRAATHLSWHPDGNRKLAVAYSCLDFQRAPVGMSSDSYIWDLENPNKPELAL 213
               |..:..|:|..|           .|.||:                   :|:....|.||..|
pombe   209 ---ITSYAKPKEALR-----------TRGLAI-------------------VWNQRWKNSPESVL 240

Human   214 KPSSPLVTLEFNPKDSHVLLGGCYNGQIACWDTRKGSLVAELSTIES-SHRDPVYGTIWLQSKTG 277
            |..|.:...:.:|....::.||.||||:..||.|:|......:||.| .|.:||....::.:...
pombe   241 KARSEITVCKPSPFHPQLIAGGAYNGQVFLWDLRQGQYPVSFTTIISGGHLEPVTDITYINNPPS 305

Human   278 TECFSASTDGQVMWWDIRKMSEPTEVVILDITKKEQLENALGAISLEFESTLPTKFMVGTEQGIV 342
            ....:.||||.|..|:....|.|:|.:.|. ::.:.....:.|..|.|......:|:||.|.| .
pombe   306 NNIVTCSTDGLVHIWEPDMFSRPSETICLS-SQVDSSSQCIPATCLSFIPENNMEFLVGAEDG-K 368

Human   343 ISCNRKAKTSAEKIV----CTFPGHHGPIYAL------QRNPFYPKN---FLTVG-DWTARIW-- 391
            :....::..|..|.|    .::.||:..|..:      .:|.|..||   .||.. |||.|:|
pombe   369 LQRGYRSDYSETKAVQPSNVSYEGHNVFISGIDVMTSNSQNVFLEKNKDFALTSSFDWTVRLWQC 433

Human   392 -----------SEDSRESSIM---WTKYHMAYLTDAAWSPVRPTVFFTTRMDGTLDIWDFMFEQC 442
                       |.|..|..|:   .|..|.|.:.|..|....|..|.:....|.|::||...:..
pombe   434 SPSRNQHELVPSNDLDEQVIINSCKTFTHKAMVFDVKWCVSEPCCFASVDALGNLNLWDLQKDVE 498

Human   443 DPTLSLKVCDEALFCLRVQDNGCLIACGSQLGTTTLLE-VSPGLS 486
            .|..|.....:.|..:..|.....:|||...|...:.: :||.|:
pombe   499 APVTSDIPDGKPLNKIAWQPEKRNLACGGLNGNVHIYKHLSPNLA 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNAI2	NP_001340096.1	WD40	166..472	CDD:475233	84/336 (25%)
		WD40 repeat	166..215	CDD:293791	8/48 (17%)
		WD40 repeat	220..259	CDD:293791	12/38 (32%)
		WD40 repeat	267..307	CDD:293791	9/39 (23%)
		WD40 repeat	314..361	CDD:293791	11/50 (22%)
		WD40 repeat	367..403	CDD:293791	16/61 (26%)
		WD40 repeat	410..435	CDD:293791	6/24 (25%)
		WD40 repeat	455..489	CDD:293791	9/33 (27%)
		DUF4795	493..>562	CDD:464990
dic1	NP_001342791.1	WD40	243..536	CDD:475233	76/294 (26%)
		WD40 repeat	247..289	CDD:293791	14/41 (34%)
		WD40 repeat	294..339	CDD:293791	11/45 (24%)
		WD40 repeat	348..390	CDD:293791	10/42 (24%)
		WD40 repeat	397..453	CDD:293791	15/55 (27%)
		WD40 repeat	466..504	CDD:293791	9/37 (24%)
		WD40 repeat	511..535	CDD:293791	6/23 (26%)