Protein Alignment DNAI2 and Dnai2

DIOPT Version :10

• Sequence 1: NP_001340096.1
• Gene: DNAI2 / 64446
• HGNCID: 18744
• Length: 649
• Species: Homo sapiens
• Sequence 2: NP_001030050.2
• Gene: Dnai2 / 432611
• MGIID: 2685574
• Length: 623
• Species: Mus musculus
• Alignment Length: 648
• Identity: 521/648 - (80%)
• Similarity: 566/648 - (87%)
• Gaps: 34/648 - (5%)

Human     1 MEIVYVYVKKRSEFGKQCNFSDRQAELNIDIMPNPELAEQFVERNPVDTGIQCSISMSEHEANSE 65
            |||||||:|||||||||||||||||||||||:||||||..:|||||||||||||.||||||||:|
Mouse     1 MEIVYVYLKKRSEFGKQCNFSDRQAELNIDILPNPELAALYVERNPVDTGIQCSASMSEHEANTE 65

Human    66 RFEMETRGVNHVEGGWPKDVNPLELEQTIRFRKKVEKDENYVNAIMQLGSIMEHCIKQNNAIDIY 130
            |||||:.|||||||||||||||.||||||||||||||||||:||:||||||||||||||||||||
Mouse    66 RFEMESCGVNHVEGGWPKDVNPQELEQTIRFRKKVEKDENYINAVMQLGSIMEHCIKQNNAIDIY 130

Human   131 EEYFNDEEAMEVMEEDPSAKTINVFRDPQEIKRAATHLSWHPDGNRKLAVAYSCLDFQRAPVGMS 195
            ||||:||||:||.||.|||||||||||||||||.|||||||||||||||||||||.|||||:.|:
Mouse   131 EEYFDDEEAVEVTEEAPSAKTINVFRDPQEIKRTATHLSWHPDGNRKLAVAYSCLKFQRAPMSMN 195

Human   196 SDSYIWDLENPNKPELALKPSSPLVTLEFNPKDSHVLLGGCYNGQIACWDTRKGSLVAELSTIES 260
            .|||||||||||:||:||||.|||||||:|||||||||||||||||||||||||||||||||||.
Mouse   196 YDSYIWDLENPNRPEIALKPLSPLVTLEYNPKDSHVLLGGCYNGQIACWDTRKGSLVAELSTIEF 260

Human   261 SHRDPVYGTIWLQSKTGTECFSASTDGQVMWWDIRKMSEPTEVVILDITKKEQLENALGAISLEF 325
            ||||||||||||||||||||||||||||||||||||:|||.||||:||::|||||||||||||||
Mouse   261 SHRDPVYGTIWLQSKTGTECFSASTDGQVMWWDIRKISEPIEVVIMDISRKEQLENALGAISLEF 325

Human   326 ESTLPTKFMVGTEQGIVISCNRKAKTSAEKIVCTFPGHHGPIYALQRNPFYPKNFLTVGDWTARI 390
            ||||||||||||||||||||||||||.||||||||.|||||||||||||||||||||||||||||
Mouse   326 ESTLPTKFMVGTEQGIVISCNRKAKTQAEKIVCTFYGHHGPIYALQRNPFYPKNFLTVGDWTARI 390

Human   391 WSEDSRESSIMWTKYHMAYLTDAAWSPVRPTVFFTTRMDGTLDIWDFMFEQCDPTLSLKVCDEAL 455
            ||||||||||||||||||||:|.|||||||.|||||:|||||||||.:|:||||.|||||||:.|
Mouse   391 WSEDSRESSIMWTKYHMAYLSDGAWSPVRPAVFFTTKMDGTLDIWDLVFKQCDPALSLKVCDDPL 455

Human   456 FCLRVQDNGCLIACGSQLGTTTLLEVSPGLSTLQRNEKNVASSMFERETRREKILEARHREMRLK 520
            ||||||||||||||||:||||||||||..||||||||||:|||:|||||||||||||||||||||
Mouse   456 FCLRVQDNGCLIACGSELGTTTLLEVSSSLSTLQRNEKNIASSIFERETRREKILEARHREMRLK 520

Human   521 EKGKAEGRDEEQTDEELAVDLEALVSKAEEEFFDIIFAELKKKEADAIKLTPVPALFCTSGERKK 585
            ||||.||::::|.:||.|:||:.||.|||||||::||:|||:|||:|:|..|.|        |||
Mouse   521 EKGKVEGKEDDQKEEEAALDLDELVGKAEEEFFEVIFSELKRKEAEALKKKPKP--------RKK 577

Human   586 RHCLSGSPPSGPTDKMPRYERAKEQRGREKKQRQQPSPEED------QVVEEGEEAAGEEGDE 642
                       .:.|:...|..:|..|.|         ||.      ..||:..|.||||.::
Mouse   578 -----------SSVKVEAEEEVEENVGEE---------EEAGGIIGIDAVEDMSEEAGEEQED 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNAI2	NP_001340096.1	WD40	166..472	CDD:475233	278/305 (91%)
		WD40 repeat	166..215	CDD:293791	41/48 (85%)
		WD40 repeat	220..259	CDD:293791	37/38 (97%)
		WD40 repeat	267..307	CDD:293791	37/39 (95%)
		WD40 repeat	314..361	CDD:293791	45/46 (98%)
		WD40 repeat	367..403	CDD:293791	35/35 (100%)
		WD40 repeat	410..435	CDD:293791	20/24 (83%)
		WD40 repeat	455..489	CDD:293791	30/33 (91%)
		DUF4795	493..>562	CDD:464990	51/68 (75%)
Dnai2	NP_001030050.2	WD40 repeat	165..212	CDD:293791	40/46 (87%)
		WD40	166..472	CDD:475233	278/305 (91%)
		WD 1	214..254		37/39 (95%)
		WD40 repeat	220..259	CDD:293791	37/38 (97%)
		WD 2	261..302		39/40 (98%)
		WD40 repeat	266..361	CDD:293791	88/94 (94%)
		WD40 repeat	318..351	CDD:293791	32/32 (100%)
		WD 3	362..401		38/38 (100%)
		WD40 repeat	367..403	CDD:293791	35/35 (100%)
		WD 4	405..445		32/39 (82%)
		WD40 repeat	410..435	CDD:293791	20/24 (83%)
		WD 5	450..489		33/38 (87%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	565..602		15/64 (23%)