Protein Alignment DNAI2 and dyci-1

DIOPT Version :10

• Sequence 1: NP_001340096.1
• Gene: DNAI2 / 64446
• HGNCID: 18744
• Length: 649
• Species: Homo sapiens
• Sequence 2: NP_001370459.1
• Gene: dyci-1 / 177440
• WormBaseID: WBGene00015927
• Length: 643
• Species: Caenorhabditis elegans
• Alignment Length: 503
• Identity: 116/503 - (23%)
• Similarity: 216/503 - (42%)
• Gaps: 71/503 - (14%)

Human    34 NPELAEQFVERNPVDTGIQCSISMSEHEANSERFEMETRGVNHVEGGWPKDVNPLELEQTIRFRK 98
            |.|:|:...:....|.|:          ...|..|.:|:.|        :.|.||..|:..|
 Worm   179 NEEIAKLLGQTKQGDKGL----------TRQETEEKKTQTV--------QIVPPLSDEEKYR--- 222

Human    99 KVEKDENYVNAIMQLGSIMEHCIKQNNAIDIYEEYFNDEEAMEVMEEDPSAKTINVFRDPQ-EIK 162
             :..|..::::..:...::...:  |..|||...|..|.....:..:| ......|::|.. ..|
 Worm   223 -LTLDPEFLDSFNRSCKVISRAL--NEEIDICINYTKDPYEKAIASDD-LLHLAQVYQDETWTAK 283

Human   163 RAATHLSW---HPDGNRKLAVAYSCLDFQRAPVGMSSDSYIWDLENPN-KPELALKPSSPLVTLE 223
            |..|.:::   :||   .|||:|...|....|.|:   ..:|:.::.. ..|..:...|.:.::.
 Worm   284 RLVTGMAFSEHYPD---LLAVSYGPCDIPNEPPGV---IVVWNTKSKRMTAEFIVYCQSEIQSVA 342

Human   224 FNPKDSHVLLGGCYNGQIACWDTRKGSLVAELSTIESSHRDPVYGTIWLQSKTGTE----CFSAS 284
            |....:|:||.||.:|||..||.|..|....::....:.:...| |:...:..||:    ..|.|
 Worm   343 FARFHAHLLLAGCESGQICVWDNRLTSRKLPINRSPLTTQAHTY-TVSCLAVVGTKNAHNFVSLS 406

Human   285 TDGQVMWWDIRKMSEPTEVVILDITKKEQLENALGAISLEFESTLPTKFMVGTEQGIVISCNRKA 349
            .||::..|::..:::|.:...| :||:.:   |..|..:.|.......|:|||:.|.:::.:|..
 Worm   407 RDGRICSWNVDNLTQPVDGKEL-MTKEGK---AASATRMSFPIGEMQTFVVGTDTGEILAASRNG 467

Human   350 KTSA--EKIVCTFPGHHGPIYALQRNPFYPKN--------FLTVG-DWTARIWSEDSRESSIMWT 403
            ...|  :..|| :.||.|.:..::   |:..:        |::.. |||.::||  ::::::.::
 Worm   468 ADPAVIKTDVC-YKGHSGTLTGIE---FHRASGVVDFSHLFISSSHDWTVKLWS--TKDANLKFS 526

Human   404 -KYHMAYLTDAAWSPVRPTVFFTTRMDGTLDIWDFMFEQCDPTLSLKVC--DEALFCLRV--QDN 463
             :.|...:.|.|||||.|.||.:...||.:.:|:...:...|...|:..  .|:::..|:  ..:
 Worm   527 FESHPDLVLDVAWSPVHPAVFASIDADGNIFVWNLNEDVEGPVARLRAGAEGESVYMNRLIWSPD 591

Human   464 GCLIACGSQLGTTTLLEVSPGLSTLQRNEKN----VASSMFERETRRE 507
            |..:..|...|...:.:|...|..|:..|.|    |.|.|.:.....|
 Worm   592 GKHVFVGDDEGRVHMYDVRESLYVLKSEEWNRFARVLSDMKQSNEEAE 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNAI2	NP_001340096.1	WD40	166..472	CDD:475233	80/329 (24%)
		WD40 repeat	166..215	CDD:293791	12/52 (23%)
		WD40 repeat	220..259	CDD:293791	13/38 (34%)
		WD40 repeat	267..307	CDD:293791	10/43 (23%)
		WD40 repeat	314..361	CDD:293791	12/48 (25%)
		WD40 repeat	367..403	CDD:293791	7/44 (16%)
		WD40 repeat	410..435	CDD:293791	11/24 (46%)
		WD40 repeat	455..489	CDD:293791	6/35 (17%)
		DUF4795	493..>562	CDD:464990	5/19 (26%)
dyci-1	NP_001370459.1	WD40	<257..610	CDD:441893	87/370 (24%)
		WD40 repeat	286..333	CDD:293791	12/52 (23%)
		WD40 repeat	339..383	CDD:293791	13/43 (30%)
		WD40 repeat	388..457	CDD:293791	18/72 (25%)
		WD40 repeat	487..528	CDD:293791	7/45 (16%)
		WD40 repeat	534..573	CDD:293791	13/38 (34%)
		WD40 repeat	581..609	CDD:293791	4/27 (15%)