Protein Alignment CIAO3 and CG17683

DIOPT Version :10

• Sequence 1: NP_071938.1
• Gene: CIAO3 / 64428
• HGNCID: 14179
• Length: 476
• Species: Homo sapiens
• Sequence 2: NP_001036428.1
• Gene: CG17683 / 3355011
• FlyBaseID: FBgn0262115
• Length: 477
• Species: Drosophila melanogaster
• Alignment Length: 487
• Identity: 230/487 - (47%)
• Similarity: 316/487 - (64%)
• Gaps: 24/487 - (4%)

Human     3 SPFSGALQLTDLDDFIGPSQECIKPVKVEKRAGSGVAKIRIEDDGSYFQINQDGGTRRLEKAKVS 67
            |..|.||||||:||||.|||.|||||:::|......|||:|:.||.:.:  .:.|..:|.|..:|
  Fly     2 SRLSRALQLTDIDDFITPSQICIKPVQIDKARSKTGAKIKIKGDGCFEE--SESGNLKLNKVDIS 64

Human    68 LNDCLACSGCITSAETVLITQQSHEELKKVLDANKMAAPSQQ----RLVVVSVSPQSRASLAARF 128
            |.|||||||||||||.|||||||.|||.|||..|.....|:.    |.:|.:::.|...|||.|:
  Fly    65 LQDCLACSGCITSAEEVLITQQSREELLKVLQENSKNKASEDWDNVRTIVFTLATQPILSLAYRY 129

Human   129 QLNPTDTARKLTSFFKKIGVHFVFDTAFSRHFSLLESQREFVRRFRGQADCRQALPLLASACPGW 193
            |:...|.||.|..:|:.:|..:|..|..:...:|||.::|||.|:|.    .:.|.:|:|:||||
  Fly   130 QIGVEDAARHLNGYFRSLGADYVLSTKVADDIALLECRQEFVDRYRE----NENLTMLSSSCPGW 190

Human   194 ICYAEKTHGSFILPHISTARSPQQVMGSLVKDFFAQQQHLTPDKIYHVTVMPCYDKKLEASRPDF 258
            :||||||||:|:||::||.|||||:||.|||...|.:.::...:||||||||||||||||||.||
  Fly   191 VCYAEKTHGNFLLPYVSTTRSPQQIMGVLVKQILADKMNVPASRIYHVTVMPCYDKKLEASREDF 255

Human   259 FNQEHQTRDVDCVLTTGEVFRLLEEEGVSLPDLEPAPLDSLCSGASAEEPT-SHRGGGSGGYLEH 322
            |::.:.:||||||:|:.||.:||.|....|...:...||...|....|... :|....||||.||
  Fly   256 FSKANNSRDVDCVITSVEVEQLLSEAQQPLSQYDLLDLDWPWSNVRPEFMVWAHEKTLSGGYAEH 320

Human   323 VFRHAARELFGIHV-AEVTYKPLRNKDFQEVTLEKEGQVLLHFAMAYGFRNIQNLVQRLKRGRCP 386
            :|::||:.:|...: .|:.:|.|:|:||:|:.|::.|:.:|.||:|.||||||||||:|||.:..
  Fly   321 IFKYAAKHIFNEDLKTELEFKQLKNRDFREIILKQNGKTVLKFAIANGFRNIQNLVQKLKREKVS 385

Human   387 -YHYVEVMACPSGCLNGGGQLQAPDRPS-----RELLQHVERLYGMVRAEAPEDAPGVQELYTHW 445
             ||:||||||||||:|||.|:    ||:     |||.:.:|.||..:....||::. .:.:|..:
  Fly   386 NYHFVEVMACPSGCINGGAQI----RPTTGQHVRELTRKLEELYQNLPRSEPENSL-TKHIYNDF 445

Human   446 LQGTDSECAGRLLHTQYH-AVEKASTGLGIRW 476
            |.|..|:.:..:|||:|| .|.:.|..|.|.|
  Fly   446 LDGFQSDKSYDVLHTRYHDVVSELSISLNINW 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CIAO3	NP_071938.1	Fe_hyd_lg_C	112..403	CDD:397172	142/293 (48%)
		Fe_hyd_SSU	418..466	CDD:214899	14/48 (29%)
CG17683	NP_001036428.1	Fe_hyd_lg_C	111..403	CDD:397172	143/295 (48%)
		Fe_hyd_SSU	419..465	CDD:214899	14/46 (30%)