DRSC/TRiP Functional Genomics Resources

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Protein Alignment INF2 and capu

DIOPT Version :10

Sequence 1:NP_001413791.1 Gene:INF2 / 64423 HGNCID:23791 Length:1268 Species:Homo sapiens
Sequence 2:NP_001137784.1 Gene:capu / 33611 FlyBaseID:FBgn0000256 Length:1361 Species:Drosophila melanogaster


Alignment Length:694 Identity:179/694 - (25%)
Similarity:281/694 - (40%) Gaps:172/694 - (24%)


- Green bases have known domain annotations that are detailed below.


Human   313 EALESLVNRAVLLASDAQECT----LEEVVERLLSVKGRP--RPS-------PLVKAHKSVQANL 364
            :.|:.::.:.:|      .||    :..||..|||....|  |||       .|:.|.::.....
  Fly   674 KTLQQILKKRLL------NCTTLAEVHAVVNELLSSVDEPPRRPSKRCVNLTELLNASEATVYEY 732

Human   365 DQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILKVSQPRALEQ-----QASTPPPP 424
            :::......::.|..:...|.:.......|       .:|..|||...:.::     .|..||||
  Fly   733 NKTGAEGCVKSFTDAETQTESEDCEGTCKC-------GQSSTKVSDNESAKEDGEKPHAVAPPPP 790

Human   425 PPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPP 489
            ||||.|....|.||||||||             ||||||...|  |||.||.|||..||.   ||
  Fly   791 PPPPPLHAFVAPPPPPPPPP-------------PPPPPLANYG--APPPPPPPPPGSGSA---PP 837

Human   490 PPPPLP---GLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWV 551
            ||||.|   |.|.||||||:      ...|....:.|.....|..|.                |.
  Fly   838 PPPPAPIEGGGGIPPPPPPM------SASPSKTTISPAPLPDPAEGN----------------WF 880

Human   552 PSHR-------RVNPPTLRMKKLNWQKL---------PSNVAREHNSMWASLSSPD--------- 591
              ||       .||||. .|:.|.|.::         |.:||...:|...|.||||         
  Fly   881 --HRTNTMRKSAVNPPK-PMRPLYWTRIVTSAPPAPRPPSVANSTDSTENSGSSPDEPPAANGAD 942

Human   592 -------------AEAVEPDFSSIE---RLFS----FPAAKPKEPTMVAPRARKEPKEITFLDAK 636
                         .|..|....:|:   .|||    .|.:||||..:      |..|.|..||.:
  Fly   943 APPTAPPATKEIWTEIEETPLDNIDEFTELFSRQAIAPVSKPKELKV------KRAKSIKVLDPE 1001

Human   637 KSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASA 701
            :|.|:.|..:.....:.|:...|...||:...:|.|:.:..:...:.|::.::........|...
  Fly  1002 RSRNVGIIWRSLHVPSSEIEHAIYHIDTSVVSLEALQHMSNIQATEDELQRIKEAAGGDIPLDHP 1066

Human   702 DHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGN 766
            :.|.|.:..|.....||.|::........:.::..|.:.|....:.|:.|..|.:...:||.:||
  Fly  1067 EQFLLDISLISMASERISCIVFQAEFEESVTLLFRKLETVSQLSQQLIESEDLKLVFSIILTLGN 1131

Human   767 FLNYGS-HTGDADGFKISTLLKLTETKSQQNRVTLLHHVL------EEAEKSHPDLLQLPRDLEQ 824
            ::|.|: ..|.||||.:..|.||.:.||:::..||||.::      ...|..||..::||  :.:
  Fly  1132 YMNGGNRQRGQADGFNLDILGKLKDVKSKESHTTLLHFIVRTYIAQRRKEGVHPLEIRLP--IPE 1194

Human   825 PS---QAAGINLEIIRSEASSNLKKLL----ETERKVSASVAEVQEQYTERLQASI-SAFRALDE 881
            |:   :||.::.|.::.:.....||.|    .|.:.::||..|:.|.:..:::..: .|.:::.:
  Fly  1195 PADVERAAQMDFEEVQQQIFDLNKKFLGCKRTTAKVLAASRPEIMEPFKSKMEEFVEGADKSMAK 1259

Human   882 LFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALK 925
            |.:::::         |                  |||||..::
  Fly  1260 LHQSLDE---------C------------------RDLFLETMR 1276

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
INF2NP_001413791.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..29
Drf_GBD <8..152 CDD:461886
Drf_FH3 156..341 CDD:461885 6/31 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 347..489 49/155 (32%)
FH2 554..920 CDD:418645 98/425 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 928..966
WH2_INF2 966..995 CDD:409204
actin-binding sequence 986..989 CDD:409204
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 988..1076
capuNP_001137784.1 FH2 888..1315 CDD:214697 99/425 (23%)
Blue background indicates that the domain is not in the aligned region.

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