Protein Alignment INF2 and exc-6

DIOPT Version :10

• Sequence 1: NP_001413791.1
• Gene: INF2 / 64423
• HGNCID: 23791
• Length: 1268
• Species: Homo sapiens
• Sequence 2: NP_497334.2
• Gene: exc-6 / 175277
• WormBaseID: WBGene00019030
• Length: 843
• Species: Caenorhabditis elegans
• Alignment Length: 805
• Identity: 189/805 - (23%)
• Similarity: 315/805 - (39%)
• Gaps: 220/805 - (27%)

Human   435 AEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGC 499
            |.||||||||||.|:    |..||||||                         |||||.|..
 Worm    65 ATPPPPPPPPPLISI----LQQAPPPPP-------------------------PPPPPTLKA--- 97

Human   500 PPPPPPLL----PGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPP 560
             |||||:|    |......|.|.|...|                        ::::|...:
 Worm    98 -PPPPPILGLKTPSKSLKTPTPRPKECP------------------------TSFLPKKEK---- 133

Human   561 TLRMKKLNWQKLPSNVAREHNSMWASLSSPDAEAVEPDFSSIERLFSFPAAKPKEPTMVAPRARK 625
            ..:.:.:.|.|:.::|.:: :|:|..|:.  |..|:.||..::..|...:........|..::.:
 Worm   134 KTKTRTVQWSKINASVVQD-DSVWGKLAK--ASNVDIDFDLLDNFFGIESLAVSGAAEVVKKSTR 195

Human   626 EPKEITFLDAKKSLNLNIFLKQFK---------CSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPE 681
            :...:..|.||:|.|:.|.|||||         ..|:.||           :::.|:.|..:||:
 Worm   196 KDAHVELLTAKRSQNVAIMLKQFKNIDELIDDVSQNKPVA-----------EIDALQNLFGMLPQ 249

Human   682 KHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACE 746
            ..|.|.||.:|.:.:.|:....|:..|:.|..|:||||..:.....:.::..:.|..::::...:
 Worm   250 SEEEEALRRYTGDISLLSPPSSFFYRLVQIQFYRLRIETQIFLSDFSRLMRELAPNVEILIRTSQ 314

Human   747 SLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEKS 811
            .:|||..||....:.:.:||:||..:..|:|.||.:::|.||.:.|..:...:|| |:|...|
 Worm   315 EILTSPTLPRLLLIFVNMGNYLNGNNSQGNAFGFTLNSLWKLIDLKGNKQEFSLL-HLLVTCE-- 376

Human   812 HPDLL-QLPRDLEQPSQAAGINLEIIR------SEASSNLKKLLETERKVSASVAEVQEQYTERL 869
             |||: .|..:|.....|:.|:.:.|:      .:....|:|.|||....|.:      |:.|.:
 Worm   377 -PDLVAHLQEELSTLKDASQISFDEIKISLKTLRDGRCKLEKQLETCSGASFT------QFLELI 434

Human   870 QASISAFRALDEL---FEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDRK 931
            :  |.....|||.   ::.:.:.|.:||||.||:.....|::.........:...:.|||:..|:
 Worm   435 K--IDCKFELDEFGANYDKLTELQYQLADYFCENRNTFQLDECLKIFNFLMNRLQQTLKEHVTRE 497

Human   932 EQAAKAERRKQQLAEEEARRPRGEDGKPVRKGPGKQEEVCVIDALLADIRKGFQLRKTARGRGDT 996
            .:..|.|.:|:.....|.           .|...|.|::.:.|||.|                 :
 Worm   498 TRKLKKEEKKETQTTREC-----------EKTMKKPEKIDLFDALTA-----------------S 534

Human   997 DGGSKAASMDPPRATEPVATSNPAG-----DPVGSTRCPASEPGLDATTASESRGWDLVDAVTPG 1056
            :||.::     ||       ...||     ..:|:.|.....   |.||        |..:.||.
 Worm   535 NGGPES-----PR-------KRAAGILDMRQKLGNVRIRKLR---DVTT--------LESSFTPP 576

Human  1057 PQPTLE-------QLEEGGPRPLERRSSWYV--DASDVLTT---------------EDPQCPQ-- 1095
            |.|.||       ..|....:|.:..:::.:  |....:|:               |:|:.|:
 Worm   577 PPPPLESPTDSTSSKENESVKPAKTSTNYEMCNDLESYITSLTRKRASHLPKAPPKEEPKLPEVL 641

Human  1096 --------------------PLEGAWPVTLGDAQALKPLKFSSNQPPAAGSSRQDAKDPTSLLGV 1140
                                ||..|.|:       :..|...|.:.|:..::|.....||:...|
 Worm   642 PEKSKIALKIEKIPEKIDKPPLPQAAPI-------IPKLPQKSIKAPSTVTTRSKVPPPTAAAAV 699

Human  1141 LQAEADSTSEGLEDA-VHSRGARPP 1164
            ......:|:...:.| :...|||.|
 Worm   700 RIVSVTTTTTPTKTAELRKPGARSP 724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INF2	NP_001413791.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29
		Drf_GBD	<8..152	CDD:461886
		Drf_FH3	156..341	CDD:461885
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	347..489		19/53 (36%)
		FH2	554..920	CDD:418645	95/384 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	928..966		6/37 (16%)
		WH2_INF2	966..995	CDD:409204	6/28 (21%)
		actin-binding sequence	986..989	CDD:409204	0/2 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	988..1076		20/99 (20%)
exc-6	NP_497334.2	FH2	140..487	CDD:396655	95/372 (26%)
		PHA03247	<584..834	CDD:223021	24/148 (16%)