Protein Alignment MTMR14 and EDTP

DIOPT Version :10

• Sequence 1: NP_001387447.1
• Gene: MTMR14 / 64419
• HGNCID: 26190
• Length: 673
• Species: Homo sapiens
• Sequence 2: NP_995873.2
• Gene: EDTP / 36959
• FlyBaseID: FBgn0027506
• Length: 754
• Species: Drosophila melanogaster
• Alignment Length: 781
• Identity: 240/781 - (30%)
• Similarity: 337/781 - (43%)
• Gaps: 273/781 - (34%)

Human    80 IEKRCLELFGRDYCFSVIPNTNGDICGHYPRHIVFLEYE-------------------------- 118
            |.|:|..||..||....:.||||.:...||..|:..|||
  Fly    43 ISKKCEYLFKLDYSLIELDNTNGLLSPRYPGRILIPEYEHGHMAKTLVPGNGLFGQVGGGVGGGG 107

Human   119 ----------------------------------------------------------------- 118
                                                                             
  Fly   108 SSGTTATATPLNSSAGSTGSEGVGIQAFVTFANPLQTQQQHPLQQQYPSQQMHPLHAQYPSQQPH 172

Human   119 ---------SSEKEKDT-FESTVQVSKLQDLIHRSKMARCRGRFVCPVILFKGKHICRSATLAGW 173
                     |.::.::| :|....:.::::|:..:|.||||.||..|||:::||:|||||||:..
  Fly   173 PLQQQQQQPSQQQPQNTIYEDQYDIQRMRELVTMAKYARCRQRFAVPVIMYRGKYICRSATLSVM 237

Human   174 GELYGRSGYNYFF---SGG---ADDAWADVEDVTEEDCALRSGDTHL---------FDKVRGYDI 223
            .|.|||...:|.:   |||   |.:...:..|.|:|...     ||:         :|:|...||
  Fly   238 PETYGRKVVDYAYDCLSGGNYTAPNGEENDADSTDESLI-----THMHDQAQSQFSYDEVIKSDI 297

Human   224 KLLRYLSVKYICDLMVENKKVKFGMNVTSSEKVDKAQRYADFTLLSIPYPGCEFFKEYKDRDYMA 288
            :||..|:|..|.||||||:|:|:.|.|:||||.|..:.|..|.|||:|||||||||:::|.:|||
  Fly   298 QLLHTLNVSTIVDLMVENRKIKYFMAVSSSEKADPNKHYKSFNLLSLPYPGCEFFKKFRDNNYMA 362

Human   289 EGLIFNWKQDYVDAPLSIPDF-LTHSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNSDDDSGLLVH 352
            ..|.:||||.:.||.::||:. ....:::.||:|:.||||..|||||:..|..| .:::||||:|
  Fly   363 RNLHYNWKQTFNDANINIPNMGPAADIDVAWSEYRDWDLVAITQNYLRATLKYV-QEENSGLLIH 426

Human   353 CISGWDRTPLFISLLRLSLWADGLIHTSLKPTEILYLTVAYDWFLFGHMLVDRLSKGEEIFFFCF 417
            |||||||||||:||:|||||||||||.||...::.|.|:||||:||||.|.|||.:||:|.||||
  Fly   427 CISGWDRTPLFVSLVRLSLWADGLIHQSLNAMQMAYFTLAYDWYLFGHQLPDRLKRGEDIMFFCF 491

Human   418 NFLKHITSEEFSALKTQRRKSLPARDGGFTL---EDICMLRRKDRGSTTSLGSDFSLVMESSPGA 479
            :.||.||.||||.::.::|....:..|...:   .|.|        ....|...|:|
  Fly   492 HVLKFITDEEFSIVEHRKRTKTSSSSGSSVIVIKSDCC--------DDEPLKDPFTL-------- 540

Human   480 TGSFTYEAVELVPAGAPTQAAWRKSHSSSPQSVLWNRPQPSEDRLPSQQGLAEARSSSSSSSN-- 542
                                        :.:..:.:..|.|.|             |.|:.||
  Fly   541 ----------------------------NCRDYILSFDQDSND-------------SYSNCSNCD 564

Human   543 --HSDNFFRMGSSPLEV-------PKP-RSVDHPL--PGSSL------STDYGSWQMVTGCGSI- 588
              .:|||:  .::|.:|       |.| ||...|:  |||:.      ::..||||:||..|||
  Fly   565 MSITDNFY--ATTPAQVNPLTSRSPNPKRSRTSPISVPGSNARQRQESTSSNGSWQVVTDTGSID 627

Human   589 -------------QERAVLHTDSSLPFSFPDELPNS-----CLLAALSD---------------- 619
                         |:.|.....|::|      |.|.     |.:.|.|.
  Fly   628 SMMNGSYMMRFVAQQAADGGGSSNIP------LCNGGNGYHCSINAASSGSGSGSGSSISNGSST 686

Human   620 ------------------------RETRLQEVRSAFLAAYSSTVGLRAVAPSPSGA---IGGLLE 657
                                    |:.||..||:.|:.||..|:||:....|....   ||.|.:
  Fly   687 HGFANGSSKDVGGSTMASKQCINLRKQRLNAVRAIFIQAYGKTIGLKFKEGSSMNLATFIGNLAD 751

Human   658 Q 658
            |
  Fly   752 Q 752

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MTMR14	NP_001387447.1	PH-GRAM_MTMR14	151..267	CDD:275400	54/130 (42%)
		PTP_DSP_cys	<327..410	CDD:475123	53/82 (65%)
EDTP	NP_995873.2	PH-GRAM_MTMR14	215..341	CDD:275400	54/130 (42%)
		PTP_DSP_cys	<416..486	CDD:475123	48/70 (69%)