DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DRGX and Drgx

DIOPT Version :9

Sequence 1:	XP_011538391.1	Gene:	DRGX / 644168	HGNCID:	21536	Length:	298	Species:	Homo sapiens
Sequence 2:	NP_001097075.2	Gene:	Drgx / 5740176	FlyBaseID:	FBgn0085369	Length:	587	Species:	Drosophila melanogaster

Alignment Length:	346	Identity:	111/346 - (32%)
Similarity:	136/346 - (39%)	Gaps:	123/346 - (35%)

- Green bases have known domain annotations that are detailed below.

Human     1 MFYFHCPPQLE-----------------GTATFGNHS--SGDFDDGFLRRKQRRNRTTFTLQQLE 46
            ||.:.|||.|.                 .|..:.::|  ....|:.|:|||||||||||||||||
  Fly     1 MFCYQCPPALHPCGPHPPRLPTLDYPFAATHPYTSYSYHPAIHDETFVRRKQRRNRTTFTLQQLE 65

Human    47 ALEAVFAQTHYPDVFTREELAMKINLTEARVQLANSCLKTELQIEINDTIIEHSEVEDHNFSLKG 111
            .||..|||||||||||||:|||||||||||||
  Fly    66 ELETAFAQTHYPDVFTREDLAMKINLTEARVQ--------------------------------- 97

Human   112 ARVWFQNRRAKWRKTERGASDQ---EPG-----------AKEPMAEVTP---------PPVRNIN 153
              ||||||||||||.||...:|   |.|           ::|...::|.         ||.:..:
  Fly    98 --VWFQNRRAKWRKAERLKDEQRKRENGESSSSLDKLHDSRESSPDITGEIDDDMDDLPPRQRSH 160

Human   154 SPPPGDQARSKKEALEAQ----QSLGRTVGPAGPFFPSCLPGTLLNTATYAQALS--------HV 206
            ||....|       :|.|    .|...:..|.|        |..|:::...:.||        |.
  Fly   161 SPLANGQ-------MEQQHSHSHSHSHSRSPGG--------GMHLDSSDNERPLSSNQLTATPHS 210

Human   207 ASLKGGPLCSCCVPDPMGL----SFLPTYGCQSNRTASVATLR-----------MKAREHSEAVL 256
            ||...|.: |...|.|.|:    ...|..|......:|.:..|           |.....|....
  Fly   211 ASQSLGSI-SAGSPSPSGMHREREHTPLVGGGGQGPSSPSNSRNTDSPIEVGGPMSLTTGSRMAA 274

Human   257 QSANLLPSTSSSPGPVAKPAP 277
            .|.|   |.||:|.|....||
  Fly   275 SSNN---SASSTPTPTTPHAP 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DRGX	XP_011538391.1	Homeobox	37..124	CDD:278475	47/86 (55%)
DRGX	XP_011538391.1	OAR	236..252	CDD:281777	3/26 (12%)
Drgx	NP_001097075.2	Homeobox	56..108	CDD:278475	47/86 (55%)
Drgx	NP_001097075.2	OAR	428..445	CDD:281777
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	113	1.000	Domainoid score	I6185
eggNOG	1	0.900	-	-		E33208_3B9E5
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I4243
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1097815at2759
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	1	1.000	-	-		oto90790
orthoMCL	1	0.900	-	-		OOG6_108990
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5686
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.770