DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CDH24 and LOC101886358

DIOPT Version :9

Sequence 1:	NP_071923.2	Gene:	CDH24 / 64403	HGNCID:	14265	Length:	819	Species:	Homo sapiens
Sequence 2:	XP_021336084.1	Gene:	LOC101886358 / 101886358	-ID:	-	Length:	816	Species:	Danio rerio

Alignment Length:	792	Identity:	392/792 - (49%)
Similarity:	509/792 - (64%)	Gaps:	70/792 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    41 RTRRSWVWNQFFVIEEYAGPEPVLIGKLHSDVDRGEGRTKYLLTGEGAGTVFVIDEATGNIHVTK 105
            |.:|.|:||||||:||:.|.:...:|||||:.|:|:|..:|:|:|||||::|:|:|.||:||.||
Zfish    56 RPKRGWIWNQFFVLEEHIGTDAQYVGKLHSNSDKGDGSVRYILSGEGAGSIFIINEVTGDIHATK 120

Human   106 SLDREEKAQYVLLAQAVDRASNRPLEPPSEFIIKVQDINDNPPIFPLGPYHATVPEMSNVGTSVI 170
            |||||:|:.|||.|||:|..:|:||||.|||||||||||||.|.||.||:..:|||||.:||||.
Zfish   121 SLDREKKSHYVLHAQAIDINTNKPLEPESEFIIKVQDINDNAPKFPDGPFVTSVPEMSELGTSVF 185

Human   171 QVTAHDADDPSYGNSAKLVYTVLDGLPFFSVDPQTGVVRTAIPNMDRETQEEFLVVIQAKDMGGH 235
            ||||.|||||:|||||::||:||.|.|:|||||:||::|||:.:||||.:|.:.||||||||.|.
Zfish   186 QVTATDADDPTYGNSARVVYSVLHGQPYFSVDPKTGIIRTALADMDREAREHYSVVIQAKDMAGQ 250

Human   236 MGGLSGSTTVTVTLSDVNDNPPKFPQSLYQFSVVETAGPGTLVGRLRAQDPDLGDNALMAYSILD 300
            :|||||||||.:||:|||||||||||..||..|.|:|..|..||:::|.|.|:|.||.:.||||:
Zfish   251 VGGLSGSTTVNITLTDVNDNPPKFPQKNYQVFVPESAQVGKPVGKIKANDEDIGINAEIKYSILN 315

Human   301 GEGSEAFSISTDLQGRDGLLTVRKPLDFESQRSYSFRVEATNTLIDPAYLRRGPFKDVASVRVAV 365
            .||:..||||||...|:|::|:||||::|.::.||..:.|.||.:||.|...|.|||.|::::.|
Zfish   316 PEGAAVFSISTDKDTREGVITLRKPLNYEKKKQYSLHISAENTHVDPRYSYLGSFKDDATLKITV 380

Human   366 QDAPEPPAFTQAAYHLTVPENKAPGTLVGQISAADLDSPASPIRYSILPHSDPERCFSIQPEEGT 430
            .|..|||.|:...|.:.|.||...||.||.::|.|.||..||:||.|....|.|..|.|:...|.
Zfish   381 GDVDEPPLFSMDYYIMEVYENARVGTEVGAVTARDPDSKNSPVRYFIERREDKEVYFDIESISGV 445

Human   431 IHTAAPLDREARAWHNLTVLATELGWSWGPERGWVPLLVAEWSAPAAPPQRSPVGSAVGIPQDSS 495
            |.|...||||...|||:||:|||                                      :|:.
Zfish   446 IRTTQLLDREDTPWHNITVMATE--------------------------------------EDNP 472

Human   496 AQASRVQVAIQTLDENDNAPQLAEPYDTFVCDSAAPGQLIQVIRALDRDEVGNSSHVSFQGPLGP 560
            :..|.|.|.:|.||.|||.|::....:..:|:....|.:||.|.|:|:|:..|....||..|.|.
Zfish   473 SLQSHVPVTVQVLDVNDNPPKINTEDEIIICEGTRAGHVIQTITAVDKDDFANGKGFSFSFPGGV 537

Human   561 DA--NFTVQDNRDGSASLLLPSRPAPPRHAPYLVPIELWDWGQPALSSTATVTVSVCRCQPDGSV 623
            .|  |||::||.|.:||:....|........|.:.:.:||.|:|.||||.|:|:.||.||....:
Zfish   538 SANPNFTIKDNEDSTASITARRRFHRLTQELYELAVVVWDDGEPVLSSTGTLTLRVCSCQRGTRL 602

Human   624 ASCWPEAHLSAAGLSTGALLAIITCVGALLALVVLFVALRRQKQEALMVLEEEDVRENIITYDDE 688
            ..|..||.||:||||||||:||:.|:..|||:|:||:.|||.|:|.| ::.|||:|||::|||||
Zfish   603 KICQSEAFLSSAGLSTGALIAILLCILILLAIVILFITLRRSKKEPL-IISEEDIRENVVTYDDE 666

Human   689 GGGEEDTEAFDITALQNPDGAAPPAPGPPARRDVLP---RARVSRQP-----RPPG-----PADV 740
            ||||||||||||.||:||..|..    ...||||.|   |...||:|     .|..     ..||
Zfish   667 GGGEEDTEAFDIIALRNPAAAEE----LKFRRDVQPECIRPWSSRRPIRSRLSPSSLDIDEETDV 727

Human   741 AQLLALRLREADEDPGVPPYDSVQVYGYEGRGSSCGSLSSLGSGSEAGGAPG-----PAEPLDDW 800
            .:.:..|:.|||:|..||||||:|.|.|||:||..||:|||||       ||     ....||||
Zfish   728 GEFIKQRVSEADQDTSVPPYDSLQTYAYEGQGSPAGSVSSLGS-------PGAHSDLDYNSLDDW 785

Human   801 GPLFRTLAELYG 812
            ||.|..:|||||
Zfish   786 GPKFEKIAELYG 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDH24	NP_071923.2	CA	70..148	CDD:214520	51/77 (66%)
		Cadherin_repeat	154..255	CDD:206637	68/100 (68%)
		Cadherin_repeat	264..368	CDD:206637	48/103 (47%)
		Cadherin_repeat	379..513	CDD:206637	44/133 (33%)
		E_set	521..615	CDD:298831	34/95 (36%)
		Cadherin_C	671..812	CDD:279398	77/158 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..800		16/36 (44%)
LOC101886358	XP_021336084.1	CA	85..163	CDD:214520	51/77 (66%)
		Cadherin_repeat	169..270	CDD:206637	68/100 (68%)
		Cadherin_repeat	279..385	CDD:206637	49/105 (47%)
		Cadherin_repeat	394..490	CDD:206637	44/133 (33%)
		Cadherin_repeat	499..594	CDD:206637	34/94 (36%)
		Cadherin_C	642..799	CDD:307269	84/168 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000109
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100413
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810