DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HHIP and K12G11.6

DIOPT Version :9

Sequence 1:	NP_071920.1	Gene:	HHIP / 64399	HGNCID:	14866	Length:	700	Species:	Homo sapiens
Sequence 2:	NP_001024057.2	Gene:	K12G11.6 / 3565780	WormBaseID:	WBGene00010792	Length:	186	Species:	Caenorhabditis elegans

Alignment Length:	215	Identity:	42/215 - (19%)
Similarity:	63/215 - (29%)	Gaps:	71/215 - (33%)

- Green bases have known domain annotations that are detailed below.

Human   448 LTILC------SDSNGKNRSSARILQIIKGKDYESEPSLLEFKPFSNGPLVGGFVYRGCQSERLY 506
            |.:||      |..:..||...:..:..|...|..:..|....|         |:|.||
Worm     8 LIVLCLFSLSHSCQDPPNRGHTKCGKAQKSIKYYFDKKLEMCLP---------FLYSGC------ 57

Human   507 GSYVFGDRNGNFLTLQQSPVTKQWQEKPLCLGTSGSCRGYFSGHILGFGEDELGEVYILSSSKSM 571
                    .||         |.::.:..:|   :..||....| |.|.|...|..    .|:::.
Worm    58 --------GGN---------TNRFDDSEMC---NLRCRAADKG-ICGGGSKALAN----CSNRNK 97

Human   572 TQTHNGKLY------------KIVDPKRPLMPEECRATVQPAQTLTSECS---------RLCRNG 615
            |.....:..            ||.:..|......|..   |...:.:|.:         |.|.:.
Worm    98 TCPKGSRCIIMAFGLGLCCDEKIQEAWRQENHPVCNI---PNHEVVTETAWYGEQELLGRHCGHK 159

Human   616 YCTPTGKCCCSPGWEGDFCR 635
            :| |.|..|....|....||
Worm   160 FC-PIGSKCVEGRWLAHCCR 178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HHIP	NP_071920.1	Folate_rec	38..220	CDD:281076
		GSDH	226..>428	CDD:285269
		Interaction with SHH zinc binding site	376..388
K12G11.6	NP_001024057.2	KU	20..74	CDD:197529	14/88 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4295
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900