Protein Alignment HHIP and T22F7.3

DIOPT Version :9

• Sequence 1: NP_071920.1
• Gene: HHIP / 64399
• HGNCID: 14866
• Length: 700
• Species: Homo sapiens
• Sequence 2: NP_497207.4
• Gene: T22F7.3 / 188757
• WormBaseID: WBGene00020702
• Length: 1517
• Species: Caenorhabditis elegans
• Alignment Length: 568
• Identity: 105/568 - (18%)
• Similarity: 155/568 - (27%)
• Gaps: 244/568 - (42%)

Human   141 CKDYCKEFFYTCRGHIPGFLQTTADEFCFYYARKDGGLCFPDFPRKQVRGPASNYLDQMEEYDKV 205
            |:.||::   |||...|.|   .:.:|                          :.||::...:.:
 Worm   361 CESYCRD---TCRRGAPEF---ASSKF--------------------------SILDEVPRTNCL 393

Human   206 EEISR-KHKHNCFCIQEVVSGLRQ---PVGA-LHSGDGSQRLFILEKEGYVKILTPEGEIFKEPY 265
            ...|| ..:|.|..|     |.:|   |..: :.|.:|.:.|.....|.|.:.|...|
 Worm   394 ASTSRCDQEHQCTLI-----GSQQTCCPTASHICSANGGRMLLTKPPENYDRGLQIAG------- 446

Human   266 LDIHKLVQSGIKGGDERGLLSLAFH--PNYKKNGKLYVSYTTNQ--------------------E 308
               ||.|.......|:...::..:|  .||.       ::.|.|                    |
 Worm   447 ---HKAVTRYYYDIDQGRCVNFLYHGLGNYN-------NFLTKQDCESFCSKLVCENGNPLRIGE 501

Human   309 RW------AIGPHDHILRVVEYTVSRKNPHQVDLRTARVFLEVAELHRKHLGGQLLFGPDGFLYI 367
            .|      |..|..|         |.:..|:|...||:...    ...|.||
 Worm   502 EWQRCETNADCPSSH---------SCQGSHKVCCPTAQSLC----TQPKRLG------------- 540

Human   368 ILGDGMITLDDMEEMDGLSDFTGSVLR--LDVDTDMCNV-PYSIPRSNPHFNSTNQPPEVFAHGL 429
                               |.|.:|.|  .:..|..|.: .|:..:.|.:..:|....:....|:
 Worm   541 -------------------DCTSAVRRYWYNAATRSCEMFQYTGCQGNDNNFNTLMACQQKCRGI 586

Human   430 HDPGRCAVDRHPTDININLTILCSDSNGKNRSSARILQIIKGKDYESEPSLLEFKPF-------- 486
            |...:|...|...|.|.|.. .|||.....:.....:....|..:...|:    |.|
 Worm   587 HVEPKCQHGRAFRDRNGNFQ-QCSDKQNGPKCPVNYVCSFDGTTHGCCPT----KAFTCSLNPDK 646

Human   487 ---------------SNGPLVGGFVYRGCQSERLYGSYVFGDRNGNFLTLQQSPVTKQWQEKPLC 536
                           ||......|.|.||.          |:.| |||
 Worm   647 GVQCGSGRSYRYYFNSNKQSCESFQYEGCD----------GNAN-NFL----------------- 683

Human   537 LGTSGSCRGYFSGHILGFG----------EDELGEVYILSSSKSMTQTHNGKLYKIVDPKRPLMP 591
              ||..|:     |..|.|          ::...:....|..||...||
 Worm   684 --TSEDCQ-----HYCGVGGCPNGGMPLRDEATNKPMSCSEQKSCPSTH---------------- 725

Human   592 EECRATVQPAQTLTSECSRLCRNGY----CTPTGKCCCS-PGWEGDFC 634
                           ||..:..||:    |.||.:..|| |..:|:.|
 Worm   726 ---------------ECLTIPVNGHVGSRCCPTKQHICSQPPQQGNHC 758

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHIP	NP_071920.1	Folate_rec	38..220	CDD:281076	15/79 (19%)
		GSDH	226..>428	CDD:285269	40/236 (17%)
		Interaction with SHH zinc binding site	376..388		0/11 (0%)
T22F7.3	NP_497207.4	EB	144..199	CDD:396311
		KU	311..365	CDD:197529	1/3 (33%)
		KU	<450..486	CDD:197529	7/42 (17%)
		Kunitz_BPTI	533..584	CDD:394972	12/86 (14%)
		Kunitz_BPTI	639..693	CDD:394972	15/88 (17%)
		Kunitz_BPTI	747..800	CDD:394972	5/12 (42%)
		Lustrin_cystein	1077..1118	CDD:405330
		EB	1218..1269	CDD:396311
		EB	1295..1346	CDD:396311

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4295
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900