DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HHIP and B0222.5

DIOPT Version :9

Sequence 1:	NP_071920.1	Gene:	HHIP / 64399	HGNCID:	14866	Length:	700	Species:	Homo sapiens
Sequence 2:	NP_505373.1	Gene:	B0222.5 / 181860	WormBaseID:	WBGene00015056	Length:	369	Species:	Caenorhabditis elegans

Alignment Length:	384	Identity:	80/384 - (20%)
Similarity:	122/384 - (31%)	Gaps:	120/384 - (31%)

- Green bases have known domain annotations that are detailed below.

Human   363 GFLYI--ILGD----------GMITLDDMEEMDGLS-DFTGSVLRLDVDTDMCNVPYSIPRSNPH 414
            ||..:  :.||          |..||:|    |||. :..|....:..:::.|   |.:   .||
Worm    11 GFTQVNALFGDRLLRARNPKTGPCTLND----DGLKCNENGYYETVQCNSESC---YCV---TPH 65

Human   415 F------NSTNQP-------------PEVFAHGLHDP------GRCAV---DRHPTDININLT-I 450
            .      ..||.|             .::||.|  ||      .:|.|   |..|...:.... .
Worm    66 TALVAYDTRTNNPKTAPKCGTCLVYLQKLFADG--DPPENSFVPKCDVGKGDFEPVQCDSKKNQC 128

Human   451 LCSDSN-GK----------NRSSARILQIIKGKDYESEPSLLE---FKPFSNGPLVGGFVYRGCQ 501
            .|.|:| |:          |.:....:||....|..:.|:..:   .||.::.|:...:    |.
Worm   129 YCVDTNTGREIQGTRKPLSNTTKMNCMQIDFSIDSSAFPAFEKPDPAKPKNDQPIGKPW----CA 189

Human   502 SERLYGSYVFGDRNGNFLTLQQSPVTKQW----------QEKPLCLG------TSGSCRGYFSGH 550
            |          :||......|.....:.|          .|...|.|      ||..|  ||
Worm   190 S----------NRNAGHTCNQNKTSIRYWFDVETFQCFPFEHKGCGGNQNSYRTSSEC--YF--- 239

Human   551 ILGFGEDELGEVYILSSSKSMTQTHNGKLYKIVDPKRPLMPEECRATVQPAQTLTSECSRLCRNG 615
                 :..|.:.:..:......:..||:.|..  |:.|..|...:.|..|...|||:.   |..|
Worm   240 -----DCVLQDYFSCAMQSQPARKSNGQWYSC--PEGPDGPPGFKTTTTPGPKLTSDG---CPKG 294

Human   616 YCTPTGK---CCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQCEQVDR 671
            |....|.   .||.......:  .|..:|.|::....::..:.......||..|.  ||
Worm   295 YICSMGAFFGICCEENLTNRY--QAAFKPLCKNKKEALQTKQDDWSSAMLGKSCS--DR 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HHIP	NP_071920.1	Folate_rec	38..220	CDD:281076
		GSDH	226..>428	CDD:285269	21/96 (22%)
		Interaction with SHH zinc binding site	376..388		5/12 (42%)
B0222.5	NP_505373.1	TY	22..84	CDD:238114	15/71 (21%)
		TY	87..154	CDD:238114	14/68 (21%)
		KU	186..241	CDD:197529	14/78 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4295
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900