DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HHIP and E01G6.1

DIOPT Version :9

Sequence 1:	NP_071920.1	Gene:	HHIP / 64399	HGNCID:	14866	Length:	700	Species:	Homo sapiens
Sequence 2:	NP_510044.2	Gene:	E01G6.1 / 181387	WormBaseID:	WBGene00008449	Length:	1467	Species:	Caenorhabditis elegans

Alignment Length:	274	Identity:	64/274 - (23%)
Similarity:	89/274 - (32%)	Gaps:	97/274 - (35%)

- Green bases have known domain annotations that are detailed below.

Human   462 SARILQIIKGKDYESEPSLLEFKPFSNGP-------LVGGFVYRGCQSERLYGSY---------- 509
            |...|.|:.....|.:|:....||....|       |.|.|..|.|.|.:::.|.
Worm    11 SISTLVILANAGLECDPTSNVKKPDPGSPESYLYCNLEGSFSKRKCASGKIFNSETGECDSLMQA 75

Human   510 ------VFGD----------RNGNFLTLQQSPVTKQWQEKPLCLGTSGSCRGYFSGHILGFGEDE 558
                  :|..          ..|..||:..:|||        |..:..||.   .|:...|.| .
Worm    76 DDPIDDIFSQPFFQAPDDLCGEGIPLTILSAPVT--------CNPSISSCP---DGYSCQFYE-R 128

Human   559 LGEVYILS----SSKSMTQTHN---GKLYKIVDPKRPLMPEECRATVQPAQ-TLTSECSRLCRNG 615
            .|..|...    ::||.|...|   |::..|.           .||.:|.. .||.:.|  |..|
Worm   129 TGSSYCCQNPTPTAKSSTDKINCGEGRVTYIE-----------MATGKPRSCVLTGDNS--CPAG 180

Human   616 Y-CT----PTGKCCC---------SPGWEGDFCRTAKCEP----ACRHGGVCVRP---NKCLCKK 659
            : ||    .|.:||.         :|...|.  ...:|.|    ||::|.||.:.   ||.:|
Worm   181 FGCTLVAGTTTRCCAKDLGCATNSAPQLRGS--NPVECSPTDGSACKNGYVCSKSQYLNKFIC-- 241

Human   660 GYLGPQCEQVDRNI 673
                  |...|..|
Worm   242 ------CSNPDGEI 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HHIP	NP_071920.1	Folate_rec	38..220	CDD:281076
		GSDH	226..>428	CDD:285269
		Interaction with SHH zinc binding site	376..388
E01G6.1	NP_510044.2	Lustrin_cystein	95..136	CDD:291299	14/52 (27%)
		WR1	289..325	CDD:214601
		Kunitz_BPTI	330..386	CDD:278443
		Kunitz_BPTI	437..492	CDD:278443
		Kunitz_BPTI	541..596	CDD:278443
		Lustrin_cystein	860..902	CDD:291299
		Lustrin_cystein	909..951	CDD:291299
		Lustrin_cystein	963..1006	CDD:291299
		EB	1265..1321	CDD:279949
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4295
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900