Protein Alignment PALS1 and RUD3

DIOPT Version :10

• Sequence 1: NP_071919.2
• Gene: PALS1 / 64398
• HGNCID: 18669
• Length: 675
• Species: Homo sapiens
• Sequence 2: NP_014859.3
• Gene: RUD3 / 854391
• SGDID: S000005742
• Length: 484
• Species: Saccharomyces cerevisiae
• Alignment Length: 491
• Identity: 90/491 - (18%)
• Similarity: 180/491 - (36%)
• Gaps: 110/491 - (22%)

Human    14 SDSEVKNVDLASPEEHQKHREMAVD----CPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEG 74
            :|.|...: :|||::..|.....||    ..|.....:.|:......:.:::.:|::.|.:.|..
Yeast    45 TDPEADGI-VASPDDEGKDLSEGVDKQKVNDGLTVDTINPLEDKKAGDEMKELREEIERLKLELS 108

Human    75 KKQELDLNSSMRLKKLAQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEIEDLFSSLKHIQHTLV 139
            .|::.:..:.....:||.:..    :...|.|:...:|.      ||..::.:|:.:|..|..|.
Yeast   109 HKKDQETPNEDFKNELANVIK----ERDEFKTQYDTLLS------KISSMKSIFNKMKEAQKQLE 163

Human   140 DSQSQ------EDISLLLQL----VQNKDFQNAFKIHNAITVHMNKASPPFPLI-----SNAQDL 189
            :.|.|      :::.|..:|    .:|.:.|:.....|....::.|.......:     |..:.|
Yeast   164 EVQEQLTEYESQNLKLKKKLEATKTENSELQSTIVTLNTELENLEKEQESTEEVFLEYESRIEAL 228

Human   190 AQEVQTVLKPVHHKE--------------GQELTALLNT------------PHIQALLLAHDK-- 226
            ..|...:::. |.||              .|||..:|..            ..::..|.:|:|
Yeast   229 EDEKHDIIEK-HSKELNTYRKEKDQLNLQVQELMIILENNKQDISDLRTERDELRQALESHEKEK 292

Human   227 ------VAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISR--- 282
                  :.:.|:::|.:.::|  |...:...:.||.:|.:...:|   .|..|:.:::...:
Yeast   293 AVLKNSLNDLELKIEEVDNKR--EEEARERDQEVKSLRSQLDTEI---ETHNNDTEALESMKKQL 352

Human   283 -IVKGGAAEKSGLLHEGDE-VLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKE 345
             .:|..|:.|.....|..: :|:|..:......:||        |.|....::..........||
Yeast   353 EAMKEDASMKEKYEEESKQHILQIGKLRHEAIILNE--------HLTKALAMLKKSSDSESVDKE 409

Human   346 TVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGK 410
            .:.::...|...|..||           :|.::|.::| ...||       |||.:..|||:...
Yeast   410 LISNLLISFVSIPRADP-----------RKFEVLELLS-NFLNW-------DEDKKQQAGLISNN 455

Human   411 SFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRK 446
            . .:...|:.:|       |....||.....|:..|
Yeast   456 E-SKNSSAVSRT-------ESFVSLWTNYLEKESEK 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PALS1	NP_071919.2	Required for the correct localization of PALS1 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions. /evidence=ECO:0000250|UniProtKB:Q9JLB2	1..345		66/388 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34		6/19 (32%)
		Interaction with PARD6B. /evidence=ECO:0000250|UniProtKB:Q9JLB2	21..140		23/122 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	51..78		4/26 (15%)
		L27_N	123..170	CDD:462666	11/56 (20%)
		Interaction with LIN7C. /evidence=ECO:0000250|UniProtKB:Q9JLB2	181..243		16/100 (16%)
		L27	189..237	CDD:197794	14/81 (17%)
		PDZ_MPP5-like	255..334	CDD:467259	15/83 (18%)
		SH3_MPP5	349..411	CDD:212969	15/61 (25%)
		GuKc	491..661	CDD:214504
RUD3	NP_014859.3	SMC_N	88..>382	CDD:481474	52/309 (17%)
		GRAB	401..449	CDD:431241	14/66 (21%)