Protein Alignment PALS1 and sdt

DIOPT Version :10

• Sequence 1: NP_071919.2
• Gene: PALS1 / 64398
• HGNCID: 18669
• Length: 675
• Species: Homo sapiens
• Sequence 2: NP_001033835.2
• Gene: sdt / 44861
• FlyBaseID: FBgn0261873
• Length: 2020
• Species: Drosophila melanogaster
• Alignment Length: 831
• Identity: 326/831 - (39%)
• Similarity: 443/831 - (53%)
• Gaps: 199/831 - (23%)

Human     9 HVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDL-----GTRMMPIRRS----------AQLER 58
            |:..|.|..:.|   .||......|.    .||:.     |....|::..          .||:.
  Fly  1217 HLRVEKDGRLVN---CSPAPQLPDRR----APGNASSGSSGATTHPLQHQQIAQIVEPTLEQLDS 1274

Human    59 IRQQQEDMRRRREEE---GKKQEL---DLNSSMRLKKL--AQIPPK---------------TGID 100
            |::.||.:|||||||   .::.|.   .|..|.:||.|  ...|.|               .|::
  Fly  1275 IKKYQEQLRRRREEEERIAQQNEFLRNSLRGSRKLKALQDTATPGKAVAQQQQQATLATQVVGVE 1339

Human   101 NPMFDTEEGIVLESPHYAVKILEIEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKI 165
            |..:..:|    :.|. |.:|....:|.::|..:|:.|    |:..:|.|           |.::
  Fly  1340 NEAYLPDE----DQPQ-AEQIDGYGELIAALTRLQNQL----SKSGLSTL-----------AGRV 1384

Human   166 HNAITVHMNKASPPFPLISNAQDLAQEVQTVLKPVHHKE------------------GQELTALL 212
            ..|.:| :..||....|.:....|.:....|..|:||..                  ..||..||
  Fly  1385 SAAHSV-LASASVAHVLAARTAVLQRRRSRVSGPLHHSSLGLQKDIVELLTQSNTAAAIELGNLL 1448

Human   213 NTPHIQALLLAHDKVAEQ--------------------EMQLEPITDER-----------VYESI 246
            .:..::.||||||::|..                    .....|:...:           |...:
  Fly  1449 TSHEMEGLLLAHDRIANHTDGTPSPTPTPTPAIGAATGSTLSSPVAGPKRNLGMVVPPPVVPPPL 1513

Human   247 GQYG------GET-----------------------------------VKIVRIEKARDIPLGAT 270
            .|.|      ||:                                   ::|::|||:.: |||||
  Fly  1514 AQRGAMPLPRGESPPPVPMPPLATMPMSMPVNLPMSACFGTLNDQNDNIRIIQIEKSTE-PLGAT 1577

Human   271 VRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPS 335
            ||||.::|:|.|||:|||||||||||||||:||:||.|:|||.||||..||..|.|||||:::|:
  Fly  1578 VRNEGEAVVIGRIVRGGAAEKSGLLHEGDEILEVNGQELRGKTVNEVCALLGAMQGTLTFLIVPA 1642

Human   336 QQIKPPPA-------------------KET-VIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILH 380
            ..   ||:                   ::| |:||:|||||||.||.|:||||||:||||||:||
  Fly  1643 GS---PPSVGVMGGTTGSQLAGLGGAHRDTAVLHVRAHFDYDPEDDLYIPCRELGISFQKGDVLH 1704

Human   381 VISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEE----------DKEPEKSGKL 435
            |||:||||||||||||:|| |.||||:|.:|||.|||.||..|.|          |....|...|
  Fly  1705 VISREDPNWWQAYREGEED-QTLAGLIPSQSFQHQRETMKLAIAEEAGLARSRGKDGSGSKGATL 1768

Human   436 WCAKKNKKKRKKV-------LYNANKNDDYDNEEILTYEEMSLYHQPANRKRPIILIGPQNCGQN 493
            .||:|.:||:||.       ||.....|:.|.||||||||::||:..|..||||:||||.|.|::
  Fly  1769 LCARKGRKKKKKASSEAGYPLYATTAPDETDPEEILTYEEVALYYPRATHKRPIVLIGPPNIGRH 1833

Human   494 ELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEADIAAGKFIEHGEFEKNLYGT 558
            ||||||| .:.:||::|||||:|:||:.||.|.||||::||||||||.|.:|:||||:||..|||
  Fly  1834 ELRQRLM-ADSERFSAAVPHTSRARREGEVPGVDYHFITRQAFEADILARRFVEHGEYEKAYYGT 1897

Human   559 SIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQERLRALLAKEGKNPKPEELRE 623
            |::::|.|:.|||||:|:|..||||.||.||||||::.:||||.::||....:.|:..|.|||::
  Fly  1898 SLEAIRTVVASGKICVLNLHPQSLKLLRASDLKPYVVLVAPPSLDKLRQKKLRNGEPFKEEELKD 1962

Human   624 IIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLINKLDTEPQWVPSTWL 674
            ||...|:||...||.||..|:|:|.::||.:||..||.|:.||||||:.|:
  Fly  1963 IIATARDMEARWGHLFDMIIINNDTERAYHQLLAEINSLEREPQWVPAQWV 2013

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PALS1	NP_071919.2	Required for the correct localization of PALS1 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions. /evidence=ECO:0000250|UniProtKB:Q9JLB2	1..345		128/482 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34		6/24 (25%)
		Interaction with PARD6B. /evidence=ECO:0000250|UniProtKB:Q9JLB2	21..140		37/156 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	51..78		12/39 (31%)
		L27_N	123..170	CDD:462666	9/46 (20%)
		Interaction with LIN7C. /evidence=ECO:0000250|UniProtKB:Q9JLB2	181..243		18/110 (16%)
		L27	189..237	CDD:197794	16/85 (19%)
		PDZ_MPP5-like	255..334	CDD:467259	53/78 (68%)
		SH3_MPP5	349..411	CDD:212969	49/61 (80%)
		GuKc	491..661	CDD:214504	94/169 (56%)
sdt	NP_001033835.2	PDZ	<54..100	CDD:214570
		PDZ_MPP5-like	1563..1641	CDD:467259	53/78 (68%)
		SH3_MPP5	1673..1734	CDD:212969	49/61 (80%)
		GuKc	1831..2002	CDD:214504	95/171 (56%)