Protein Alignment PALS1 and magu-2

DIOPT Version :10

• Sequence 1: NP_071919.2
• Gene: PALS1 / 64398
• HGNCID: 18669
• Length: 675
• Species: Homo sapiens
• Sequence 2: NP_001355433.1
• Gene: magu-2 / 3565703
• WormBaseID: WBGene00006467
• Length: 830
• Species: Caenorhabditis elegans
• Alignment Length: 726
• Identity: 240/726 - (33%)
• Similarity: 373/726 - (51%)
• Gaps: 102/726 - (14%)

Human     9 HVTEESDSEVKNVDLASPEEHQKHRE--MAVDCP------GDLGTRMMPIRRSAQLERIRQQQED 65
            |:.|.:    |.:....||.|....|  .|...|      |.:.|....|.|.:......|.:..
 Worm   143 HIKEVT----KRLKKEYPEIHTYDMEYIAATSGPPSVAPRGSVHTNGFGIERGSLRRPPEQFEMQ 203

Human    66 MRRRREEEGKKQELDLNSSMRLKKLAQ-IPP-------KTGIDNPMFDTEEGIVLESPHYAVKIL 122
            .::|:|:|.......|..|.:|:.||: :.|       .|...||:.:.||....::.:.|.:|.
 Worm   204 EKKRKEQENTFLRSSLRKSKKLQALARNVDPLTNEPMKVTSFANPLAEVEETPSRKTENGATRIT 268

Human   123 ---------------------EIEDLFSSLKHIQHTLVDSQSQE-DISLLLQLVQNKDFQNAFKI 165
                                 :::::..|::.|...|...|.:| |:::|      :||..|..|
 Worm   269 VGEEVLESSEVLIDEENKDSRQLDEVIISVERIASKLSSMQGRESDVAML------RDFFAAPPI 327

Human   166 HNAI--TVHMNKASPPFPLISNAQDLAQEVQTVLKPVHHKEGQELTALLNTPHIQALLLAHDKVA 228
            ..||  ||..|                .:..|....:....|.:.::..::|....::..:.|
 Worm   328 QAAIEQTVKQN----------------GKCGTTSSGIGTDSGGDSSSCTSSPIPPVIMNGNGK-- 374

Human   229 EQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSG 293
               .:..|.|...  .|:.......||:|.:.|..|..||||||||.:.:|:.|:||||..||..
 Worm   375 ---SERCPSTSSS--SSVSPRNAPNVKVVEVVKDEDSYLGATVRNENNKIIVGRVVKGGIVEKMN 434

Human   294 LLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQ-------------IKPPPAKE 345
            |..||||:||:||..::||.|||:.|:|.::.|.:|||:.|.::             :....:::
 Worm   435 LFQEGDELLELNGSSLKGKQVNEICDILRNLSGPITFVVAPKEEQDTEQPTDTATNTVTAKKSQQ 499

Human   346 TVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGK 410
            .|.|::|.|||||.||.||||:||.:.||:||||||::.:|.|||||||:|::....||||:|..
 Worm   500 HVQHLRALFDYDPEDDVYVPCKELAMKFQRGDILHVLNTKDDNWWQAYRDGEDIQHSLAGLIPSS 564

Human   411 SFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDDYDN-------EEILTYEE 468
            ||:||.......:|.::|.::       |:.|.|:||.| ...|..|.:|       .:.|||||
 Worm   565 SFRQQVVLYADEVEREQEQKR-------KECKGKKKKKL-EVKKGADEENLPAIGVYSDFLTYEE 621

Human   469 MSLYHQPANRKRPIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSR 533
            :.|....|..:|||:|.|.:..|..:||.||:..::...|..||:|:|:.::.|..|..|||||:
 Worm   622 VVLELPKATHRRPIVLCGAEGVGCLKLRDRLLESDRITLACPVPYTSRTPKEGEFNGVHYHFVSK 686

Human   534 QAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIA 598
            |.|..|..:|||:|.||::|..|||:...|..||..||.|:::|:.:||..:|:.|::|||||||
 Worm   687 QKFHEDAKSGKFVEFGEYQKFWYGTAKKDVVNVIERGKTCVMTLKAESLGAIRSPDIQPYIIFIA 751

Human   599 PPSQERLRALLAKEGK-NPKPEELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLINKL 662
            .||...||.....||. ..|.:||:.|:.:::.:||..||.||..|||.|.:|:::||.:::.|:
 Worm   752 APSLYILRRQREVEGTFGVKDDELKAILTQSKSIEQKYGHLFDGIIVNIDFEKSFRELKQILMKV 816

Human   663 DTEPQWVPSTW 673
            :|||.|||:||
 Worm   817 NTEPMWVPATW 827

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PALS1	NP_071919.2	Required for the correct localization of PALS1 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions. /evidence=ECO:0000250|UniProtKB:Q9JLB2	1..345		95/388 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34		6/24 (25%)
		Interaction with PARD6B. /evidence=ECO:0000250|UniProtKB:Q9JLB2	21..140		30/155 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	51..78		5/26 (19%)
		L27_N	123..170	CDD:462666	13/49 (27%)
		Interaction with LIN7C. /evidence=ECO:0000250|UniProtKB:Q9JLB2	181..243		6/61 (10%)
		L27	189..237	CDD:197794	4/47 (9%)
		PDZ_MPP5-like	255..334	CDD:467259	40/78 (51%)
		SH3_MPP5	349..411	CDD:212969	37/61 (61%)
		GuKc	491..661	CDD:214504	71/170 (42%)
magu-2	NP_001355433.1	PDZ	<59..109	CDD:214570
		PDZ_MPP5-like	406..475	CDD:467259	36/68 (53%)
		SH3_MPP5	503..565	CDD:212969	37/61 (61%)
		GuKc	642..817	CDD:214504	72/174 (41%)