DRSC/TRiP Functional Genomics Resources

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Protein Alignment PALS1 and Pals1

DIOPT Version :10

Sequence 1:NP_071919.2 Gene:PALS1 / 64398 HGNCID:18669 Length:675 Species:Homo sapiens
Sequence 2:NP_001101504.1 Gene:Pals1 / 314259 RGDID:1308071 Length:675 Species:Rattus norvegicus


Alignment Length:675 Identity:654/675 - (96%)
Similarity:665/675 - (98%) Gaps:0/675 - (0%)


- Green bases have known domain annotations that are detailed below.


Human     1 MTTSHMNGHVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDLGTRMMPIRRSAQLERIRQQQED 65
            ||||:|||||||||||.:||:.|||||||.||||||||||||||||:||:|||||||||||||||
  Rat     1 MTTSYMNGHVTEESDSGIKNLGLASPEEHPKHREMAVDCPGDLGTRLMPVRRSAQLERIRQQQED 65

Human    66 MRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEIEDLFSS 130
            |||||||||||||||||||||||||||||||||||||:||||||||||||||||||||:||||||
  Rat    66 MRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPIFDTEEGIVLESPHYAVKILEVEDLFSS 130

Human   131 LKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNAQDLAQEVQT 195
            ||||||||||||||||||||||||||:|||||||||||:||||||||||||||:|.|||.|||||
  Rat   131 LKHIQHTLVDSQSQEDISLLLQLVQNRDFQNAFKIHNAVTVHMNKASPPFPLIANVQDLVQEVQT 195

Human   196 VLKPVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIE 260
            ||||||.|||||||||||.|||||||||||||||||||||||||||||||||.||||||||||||
  Rat   196 VLKPVHQKEGQELTALLNAPHIQALLLAHDKVAEQEMQLEPITDERVYESIGHYGGETVKIVRIE 260

Human   261 KARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMH 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   261 KARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMH 325

Human   326 GTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWW 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   326 GTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWW 390

Human   391 QAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKN 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   391 QAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKN 455

Human   456 DDYDNEEILTYEEMSLYHQPANRKRPIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRD 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||
  Rat   456 DDYDNEEILTYEEMSLYHQPANRKRPIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRNRRD 520

Human   521 QEVAGRDYHFVSRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTL 585
            .|||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||
  Rat   521 HEVAGRDYHFVSRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRAQSLKTL 585

Human   586 RNSDLKPYIIFIAPPSQERLRALLAKEGKNPKPEELREIIEKTREMEQNNGHYFDTAIVNSDLDK 650
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   586 RNSDLKPYIIFIAPPSQERLRALLAKEGKNPKPEELREIIEKTREMEQNNGHYFDTAIVNSDLDK 650

Human   651 AYQELLRLINKLDTEPQWVPSTWLR 675
            |||||||||||||||||||||||||
  Rat   651 AYQELLRLINKLDTEPQWVPSTWLR 675

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PALS1NP_071919.2 Required for the correct localization of PALS1 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions. /evidence=ECO:0000250|UniProtKB:Q9JLB2 1..345 325/343 (95%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..34 26/32 (81%)
Interaction with PARD6B. /evidence=ECO:0000250|UniProtKB:Q9JLB2 21..140 111/118 (94%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 51..78 26/26 (100%)
L27_N 123..170 CDD:462666 44/46 (96%)
Interaction with LIN7C. /evidence=ECO:0000250|UniProtKB:Q9JLB2 181..243 56/61 (92%)
L27 189..237 CDD:197794 44/47 (94%)
PDZ_MPP5-like 255..334 CDD:467259 78/78 (100%)
SH3_MPP5 349..411 CDD:212969 61/61 (100%)
GuKc 491..661 CDD:214504 166/169 (98%)
Pals1NP_001101504.1 Required for the correct localization of PALS1 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions. /evidence=ECO:0000250|UniProtKB:Q9JLB2 1..345 325/343 (95%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..32 24/30 (80%)
Interaction with PARD6B. /evidence=ECO:0000250|UniProtKB:Q9JLB2 21..140 111/118 (94%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 52..79 26/26 (100%)
L27_N 123..170 CDD:462666 44/46 (96%)
Interaction with LIN7C. /evidence=ECO:0000250|UniProtKB:Q9JLB2 181..243 56/61 (92%)
L27 189..237 CDD:197794 44/47 (94%)
PDZ_MPP5-like 255..334 CDD:467259 78/78 (100%)
SH3_MPP5 349..411 CDD:212969 61/61 (100%)
GuKc 491..661 CDD:214504 166/169 (98%)

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