Protein Alignment PALS1 and pals1a

DIOPT Version :10

• Sequence 1: NP_071919.2
• Gene: PALS1 / 64398
• HGNCID: 18669
• Length: 675
• Species: Homo sapiens
• Sequence 2: NP_919344.1
• Gene: pals1a / 252845
• ZFINID: ZDB-GENE-020712-1
• Length: 703
• Species: Danio rerio
• Alignment Length: 682
• Identity: 520/682 - (76%)
• Similarity: 585/682 - (85%)
• Gaps: 12/682 - (1%)

Human     1 MTTSHMNGHVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDLGTRMMPIRRSAQLERIRQQQED 65
            ||||||||:|||....  ...|:.. |..|:|||||||||.:||.|.:|:|||||||:|||||||
Zfish    27 MTTSHMNGYVTESDGG--GGTDIVE-EGVQRHREMAVDCPSELGARTLPVRRSAQLEKIRQQQED 88

Human    66 MRRRREEEGK-KQELDLNSSMRLKKLAQIPPKTGIDNPMFDTEEGI-----VLESPHYAVKILEI 124
             ||||||||: :||||||||||||||:| .||.|||||.|:..||.     .|:|......:||:
Zfish    89 -RRRREEEGRSRQELDLNSSMRLKKLSQ-NPKVGIDNPTFEQMEGPGGSAGGLQSLIAPPALLEL 151

Human   125 EDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNAQDL 189
            |||..|||.:||:|.|||||||:.|:|||||..|||.||.|||::..:||:.|||:||..:||.|
Zfish   152 EDLLMSLKQVQHSLNDSQSQEDVELVLQLVQKPDFQKAFSIHNSVAHYMNRPSPPYPLTDHAQTL 216

Human   190 AQEVQTVLKPVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQLEPITDE-RVYESIGQYGGET 253
            ||||:.:::...||||.||::||:|.|:|||::|||.||||||||||:... ...|::.|:||||
Zfish   217 AQEVEVMVQNSSHKEGLELSSLLSTSHMQALMMAHDSVAEQEMQLEPLVPSVNASETLTQWGGET 281

Human   254 VKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVF 318
            |||||||||:||||||||||:||||:|||||||||||:|||||||||:|||||:|||||||||||
Zfish   282 VKIVRIEKAKDIPLGATVRNDMDSVVISRIVKGGAAERSGLLHEGDEILEINGVEIRGKDVNEVF 346

Human   319 DLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVIS 383
            |:|:||||.|:||||||.|||.||.||||:|||||||||||||||||||||||.||||||||:||
Zfish   347 DILADMHGVLSFVLIPSAQIKSPPIKETVVHVKAHFDYDPSDDPYVPCRELGLCFQKGDILHIIS 411

Human   384 QEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKV 448
            |:|||||||||:||||||||||||||||||||||||||||||||||||:||||||||.||||||:
Zfish   412 QDDPNWWQAYRDGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKTGKLWCAKKTKKKRKKM 476

Human   449 LYNANKNDDYDNEEILTYEEMSLYHQPANRKRPIILIGPQNCGQNELRQRLMNKEKDRFASAVPH 513
            .||||||||:|||||||||||:||||||||||||.||||.|||||||||||::.|.||||..|||
Zfish   477 QYNANKNDDFDNEEILTYEEMALYHQPANRKRPIALIGPPNCGQNELRQRLLSTEPDRFAGPVPH 541

Human   514 TTRSRRDQEVAGRDYHFVSRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLR 578
            |||||||.|..|||||||||||||.|.|||||||.||||||.||||.||||||||:||||||.:.
Zfish   542 TTRSRRDAEANGRDYHFVSRQAFEMDSAAGKFIESGEFEKNFYGTSTDSVRQVINTGKICLLCVH 606

Human   579 TQSLKTLRNSDLKPYIIFIAPPSQERLRALLAKEGKNPKPEELREIIEKTREMEQNNGHYFDTAI 643
            |||||.||:||||||||||||||||||||||||:.|||||||||:||||.||||||.||.||.||
Zfish   607 TQSLKVLRSSDLKPYIIFIAPPSQERLRALLAKDNKNPKPEELRDIIEKAREMEQNYGHLFDAAI 671

Human   644 VNSDLDKAYQELLRLINKLDTEPQWVPSTWLR 675
            ||:||||:||||||||||||||||||||:|||
Zfish   672 VNTDLDKSYQELLRLINKLDTEPQWVPSSWLR 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PALS1	NP_071919.2	Required for the correct localization of PALS1 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions. /evidence=ECO:0000250|UniProtKB:Q9JLB2	1..345		231/350 (66%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34		15/32 (47%)
		Interaction with PARD6B. /evidence=ECO:0000250|UniProtKB:Q9JLB2	21..140		76/124 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	51..78		22/27 (81%)
		L27_N	123..170	CDD:462666	31/46 (67%)
		Interaction with LIN7C. /evidence=ECO:0000250|UniProtKB:Q9JLB2	181..243		35/62 (56%)
		L27	189..237	CDD:197794	30/47 (64%)
		PDZ_MPP5-like	255..334	CDD:467259	68/78 (87%)
		SH3_MPP5	349..411	CDD:212969	57/61 (93%)
		GuKc	491..661	CDD:214504	140/169 (83%)
pals1a	NP_919344.1	L27_N	150..197	CDD:462666	31/46 (67%)
		PDZ_MPP5-like	283..362	CDD:467259	68/78 (87%)
		SH3_MPP5	377..439	CDD:212969	57/61 (93%)
		GuKc	519..689	CDD:214504	140/169 (83%)