DRSC/TRiP Functional Genomics Resources

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Protein Alignment PALS1 and pals1

DIOPT Version :10

Sequence 1:NP_071919.2 Gene:PALS1 / 64398 HGNCID:18669 Length:675 Species:Homo sapiens
Sequence 2:XP_002937246.1 Gene:pals1 / 100145156 XenbaseID:XB-GENE-978290 Length:675 Species:Xenopus tropicalis


Alignment Length:57 Identity:15/57 - (26%)
Similarity:24/57 - (42%) Gaps:6/57 - (10%)


- Green bases have known domain annotations that are detailed below.


Human   311 KGTAVASAQANSTPTSVASVVASAESPASRQAAAKLALRKQLEKTLLEIPPPKPPAP 367
            :|...|..:|:.|.|....|...|...|..:||:|..::|..:      |.|:...|
 Frog   225 EGECSAVFEASG
TTTQAYRVDERAAEQARWEAASKETIKKTTK------PCPRCHVP 275

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PALS1NP_071919.2 Required for the correct localization of PALS1 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions. /evidence=ECO:0000250|UniProtKB:Q9JLB2 1..345 10/33 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..34
Interaction with PARD6B. /evidence=ECO:0000250|UniProtKB:Q9JLB2 21..140
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 51..78
L27_N 123..170 CDD:462666
Interaction with LIN7C. /evidence=ECO:0000250|UniProtKB:Q9JLB2 181..243
L27 189..237 CDD:197794
PDZ_MPP5-like 255..334 CDD:467259 6/22 (27%)
SH3_MPP5 349..411 CDD:212969 4/19 (21%)
GuKc 491..661 CDD:214504
pals1XP_002937246.1 L27_N 123..170 CDD:462666
L27 186..236 CDD:460717 3/10 (30%)
PDZ_MPP5-like 255..334 CDD:467259 7/27 (26%)
SH3_MPP5 349..411 CDD:212969
GuKc 491..661 CDD:214504
Blue background indicates that the domain is not in the aligned region.

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