DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kcna6 and Shawl

DIOPT Version :9

Sequence 1:	NP_076444.1	Gene:	Kcna6 / 64358	RGDID:	62083	Length:	530	Species:	Rattus norvegicus
Sequence 2:	NP_001097131.2	Gene:	Shawl / 5740840	FlyBaseID:	FBgn0085395	Length:	937	Species:	Drosophila melanogaster

Alignment Length:	575	Identity:	189/575 - (32%)
Similarity:	274/575 - (47%)	Gaps:	142/575 - (24%)

- Green bases have known domain annotations that are detailed below.

  Rat    42 RLVINISGLRYETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRL 106
            |:::|:||:||||...||...|.|.|......:..:||:.|||||||:...|..||.||:: |:|
  Fly     6 RIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQILNYYRT-GKL 69

  Rat   107 RRPVNVPLDIFMEEIRFYQLGDEAL--------AAFREDEGCL----PEGGEDEKPLPSQ----- 154
            ..|.:|...:|.||:.|:.|....:        :..|:.:..|    ....|:|||...|
  Fly    70 HYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPTEEQIARLF 134

  Rat   155 ------------PFQR---QVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRADGR 204
                        .:||   ::|.:|:.|.||..|:.:|.:||..|.:|::.|||:|.|.||.|..
  Fly   135 GFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGFRVDLP 199

  Rat   205 GGSNEGSGTRMSPASRG---SHEEEDEDEDSYAF-PGSI--PSGGLG-----TGGTS----SFST 254
            .|:::..|    |.:.|   .|:...|...::.: ..||  |||.:|     |..||    :|:.
  Fly   200 SGAHDAHG----PGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSGNFTA 260

  Rat   255 LG---------------------GSFFT--------------------------DPFFLVETLCI 272
            .|                     ||...                          :.||.||.:|.
  Fly   261 SGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYVELVCN 325

  Rat   273 VWFTFELLVRFSACPSKAAFFRNIMNIIDLVAIFPYFITLGTELVQRHEQQPVSGGSGQNGQQAM 337
            |||..|:::|....|:...|.::.:||||..|...::    |:::||..:.
  Fly   326 VWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFY----TDVMQRMGEY-------------- 372

  Rat   338 SLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAE--A 400
             ..:|....:||:.|:|||:|||.||:||..|.:||.:||.||:|||.:|::.|:|..|:||  .
  Fly   373 -TGLLEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQ 436

  Rat   401 DDVDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYF 465
            |:.|:.|.|||...|||:||||||||||:.|.|..|..||:|||:|||||||||||||||||:.|
  Fly   437 DNPDNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMF 501

  Rat   466 YHRETEQEEQGQYTHVTCGQPTPDLKATDNGLGKPDFAEASRERRSSYLPT-PHR 519
                        |:|.......|..:.....:.:|      |.:|.   || |||
  Fly   502 ------------YSHTQARSKLPKKRRRVLPVEQP------RRKRE---PTAPHR 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kcna6	NP_076444.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		BTB_2	43..132	CDD:280393	35/96 (36%)
		BTB	43..126	CDD:197585	34/82 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..239		6/39 (15%)
		Ion_trans	260..469	CDD:278921	95/236 (40%)
		S4-S5 linker. /evidence=ECO:0000250\|UniProtKB:P63142	361..374		6/12 (50%)
		Ion_trans_2	383..460	CDD:285168	48/78 (62%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	423..428		4/4 (100%)
		PDZ-binding. /evidence=ECO:0000255	527..529
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	35/92 (38%)
		BTB_2	7..97	CDD:280393	35/90 (39%)
		Ion_trans	307..506	CDD:278921	97/229 (42%)
		Ion_trans_2	<449..499	CDD:285168	37/49 (76%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910