Protein Alignment TRA2B and Ref1

DIOPT Version :10

• Sequence 1: NP_004584.1
• Gene: TRA2B / 6434
• HGNCID: 10781
• Length: 288
• Species: Homo sapiens
• Sequence 2: NP_651968.1
• Gene: Ref1 / 44029
• FlyBaseID: FBgn0010774
• Length: 266
• Species: Drosophila melanogaster
• Alignment Length: 256
• Identity: 61/256 - (23%)
• Similarity: 99/256 - (38%)
• Gaps: 42/256 - (16%)

Human     1 MSDSGEQNYGE--RESRSASRSGSAHGSGKSARHTPARSRSKEDSRRSRSKSRSRSESRSRSRRS 63
            |.|..|.:..:  :.:||..:..:|.|....||.|..:.|....:||..:.:...........:.
  Fly     1 MVDKIEMSLDDIIKSTRSQKKPQAARGGPGGARKTGGQQRFAGGARRGGANAGGSPRKPGSVLKG 65

Human    64 SRRHYTRSRSRSRSHRRSRSRSYSRDYRRRHSHSHSPMSTRRRHVGNRANPDPNCCLGVFGLSLY 128
            .|........:.....|....|     ..:|.....|   :|..||..:.|..   |.|..|...
  Fly    66 PRGGVAAGAVQKAKFPRGDVNS-----AWKHDMYDGP---KRGAVGGGSGPTR---LIVGNLDYG 119

Human   129 TTERDLREVFSKYGPIADVSIVYDQQSRRSRGFAFVYFENVDDAKEAKERANGMELDGRRIRV-- 191
            .:..|::|:|:.:|||...::.|| :|.||.|.|.|.||...||.:|.::.:|:.||||.:.:
  Fly   120 VSNTDIKELFNDFGPIKKAAVHYD-RSGRSLGTADVIFERRADALKAIKQYHGVPLDGRPMTIQL 183

Human   192 ---DFSITKRPHTPTPGIYMGRPTYGSSRRRDYYDRGYDRGYDDRDYYSRSYRGGGGGGGG 249
               |.::..||...|.   :.|...|::                    ..|::.|||..||
  Fly   184 AVSDVAVLTRPVAATD---VKRRVGGTA--------------------PTSFKRGGGQAGG 221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRA2B	NP_004584.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..114		21/114 (18%)
		RRM_TRA2	117..196	CDD:409798	28/83 (34%)
		Linker	193..230		5/36 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	196..225		5/28 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	242..288		5/8 (63%)
Ref1	NP_651968.1	sex-lethal	31..>184	CDD:273740	42/164 (26%)
		RRM_THOC4	109..183	CDD:410081	27/77 (35%)
		FoP_duplication	202..>260	CDD:464005	8/40 (20%)