Protein Alignment NSD1 and SET2

DIOPT Version :10

• Sequence 1: NP_071900.2
• Gene: NSD1 / 64324
• HGNCID: 14234
• Length: 2696
• Species: Homo sapiens
• Sequence 2: NP_012367.2
• Gene: SET2 / 853271
• SGDID: S000003704
• Length: 733
• Species: Saccharomyces cerevisiae
• Alignment Length: 837
• Identity: 199/837 - (23%)
• Similarity: 307/837 - (36%)
• Gaps: 234/837 - (27%)

Human  1839 QEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNC--KATD 1901
            :||..:||.|          :|           .|..|:.||     |...::...|:|  :.:|
Yeast    38 EEALTKFENL----------DD-----------CIYANKRIG-----TFKNNDFMECDCYEEFSD 76

Human  1902 --ENPCGIDSECINRMLLYECHPTVCPA-GGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIK 1963
              .:.|..||:||||:.|.||...:|.: |..||||.|.|:||..:.||:|..:|:|:|.:.||:
Yeast    77 GVNHACDEDSDCINRLTLIECVNDLCSSCGNDCQNQRFQKKQYAPIAIFKTKHKGYGVRAEQDIE 141

Human  1964 KGEFVNEYVGELIDEEECRAR-IRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNC 2027
            ..:|:.||.||:|:|.|.|.| |.|.|.| ..:||.:.|.....|||..||:.|||.||.|.||.
Yeast   142 ANQFIYEYKGEVIEEMEFRDRLIDYDQRH-FKHFYFMMLQNGEFIDATIKGSLARFCNHSCSPNA 205

Human  2028 ETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIAT 2092
            ...||.|....|:|:||...|..|.|:||:||::..|.....|.|..|||.||||
Yeast   206 YVNKWVVKDKLRMGIFAQRKILKGEEITFDYNVDRYGAQAQKCYCEEPNCIGFLG---------- 260

Human  2093 EEKSKKFKKKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKW 2157
                        ||.:|                ||..|:       |:.. ||.|.:|.....||
Yeast   261 ------------GKTQT----------------DAASLL-------PQNI-ADALGVTVSMEKKW 289

Human  2158 ECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGR-LSCTEHDPCGPNPLEPGEIREY 2221
                                             |.:.||.|. :...|::......|:..|::.
Yeast   290 ---------------------------------LKLKKLSGEPIIKNENENINIEFLQSLEVQP- 320

Human  2222 VPPPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPPADTNQMLSLSKKALAGTCQRPLL----PERP 2282
            :..||.:....|..|.:.:..:|::..|...  ..|.:.:...:.|....||...:|    .|:|
Yeast   321 IDSPVDVTKIMSVLLQQDNKIIASKLLKRLF--TIDDDSLRHQAIKLHGYTCFSKMLKLFITEQP 383

Human  2283 LERTDSRPQPLDKVRDLAG--------SGTKSQSLVSSQRPLDRPPAVAGPRPQLSDKPSPVTSP 2339
            ...........|.::.:.|        ..|....:.|||  :|...           |..|...|
Yeast   384 QVDGKGNETEEDDIKFIKGILDFLLELPKTTRNGIESSQ--IDNVV-----------KTLPAKFP 435

Human  2340 SSSPSVRSQPLER--PLGTADPRLDKSIGAASPRPQSLEKTSVPTG------------------- 2383
            ...|:. .:.||:  ...|......|.|..|:.:...|.:..:|.|
Yeast   436 FLKPNC-DELLEKWSKFETYKRITKKDINVAASKMIDLRRVRLPPGWEIIHENGRPLYYNAEQKT 499

Human  2384 -LRLPPPDRLLITSSPKPQTSDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQ 2447
             |..||.....:.||    .|:...:.|.:|...:.|          ..|.:|:..|.  |:..:
Yeast   500 KLHYPPSGSSKVFSS----RSNTQVNSPSSSGIPKTP----------GALDSKKHKLS--DEEYE 548

Human  2448 SKNRAALVMDLIDLTPRQKERAASPHQVTPQADEKMPVLESSSWPASKGLGHMPRAVEKGCVSDP 2512
            .|.:..|..:.|.|...::|...|..|.....:|:..|||.....|:|     .:.::|
Yeast   549 RKKQKRLEYERIALERAKQEELESLKQKLKLENERKSVLEDIIAEANK-----QKELQK------ 602

Human  2513 LQTSGKAAAPSEDPWQAVKSLTQARLLSQPPAKAFLYEPTTQASGRASAGAEQTPGPLSQSPGLV 2577
             :.:.|.....|......|:::|::.|.....|.|               |...|..:.::|
Yeast   603 -EEAKKLVEAKEAKRLKRKTVSQSQRLEHNWNKFF---------------ASFVPNLIKKNP--- 648

Human  2578 KQAKQMVGGQQLPALAAKSGQSFRSLGKAPASLPTEEKKLVTTEQSPWALGKASSRA 2634
             |:||.            ..::.:...|       :..|::||::    |.|.||||
Yeast   649 -QSKQF------------DHENIKQCAK-------DIVKILTTKE----LKKDSSRA 681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD1	NP_071900.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	207..252
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..311
		PWWP_NSD1_rpt1	318..433	CDD:438989
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	487..514
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	872..891
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	936..1035
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1067..1093
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1112..1134
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1243..1272
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1294..1344
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1382..1428
		TNG2	<1431..1587	CDD:227367
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1480..1534
		PHD1_NSD1_2	1545..1587	CDD:277118
		PHD2_NSD1	1592..1638	CDD:277120
		PHD3_NSD1	1639..1692	CDD:277123
		PHD4_NSD1	1709..1748	CDD:277126
		PWWP_NSD1_rpt2	1755..1850	CDD:438992	5/10 (50%)
		AWS	1901..1939	CDD:465559	18/40 (45%)
		SET_NSD1	1941..2082	CDD:380987	61/141 (43%)
		Inhibits enzyme activity in the absence of bound histone	2060..2066		1/5 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2091..2111		3/19 (16%)
		PHD5_NSD1	2120..2162	CDD:277129	10/41 (24%)
		C5HCH	2161..2210	CDD:465605	5/49 (10%)
		PHA03247	<2208..2574	CDD:223021	71/399 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2213..2422		44/242 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2464..2499		9/34 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2553..2575		2/21 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2595..2616		1/20 (5%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2665..2696
SET2	NP_012367.2	AWS	64..119	CDD:197795	21/54 (39%)
		SET_SETD2	119..260	CDD:380949	61/141 (43%)
		WW_1	479..505	CDD:375933	2/25 (8%)
		TolA	545..>626	CDD:442298	18/92 (20%)
		SRI	627..703	CDD:462404	19/97 (20%)